Dietary quercetin ameliorates nonalcoholic steatohepatitis induced by a high-fat diet in gerbils

Hugan QingzhiExerts Anti-Inflammatory Effects in a Rat Model of Nonalcoholic Fatty Liver Disease

“…SIRT1 activators, such as resveratrol, silibinin, and quercetin, have antioxidant and anti-inflammatory effects by modulating NF- κ B and mitogen-activated protein kinase- (MAPK-) dependent signaling pathways [48–50]. In accordance with this, another study found that quercetin significantly attenuated inflammation in NAFLD rats by increasing SIRT1 expression [51]. HPLC shows that quercetin is one of the main active components of HQT, which supports the notion that HQT possesses anti-inflammation activity.…”

Quercetin reduces obesity-associated ATM infiltration and inflammation in mice: a mechanism including AMPKα1/SIRT1

“…Briefl y, 100 l of serum was diluted with resistance ( 16 ), most recent studies have affi rmed that quercetin ameliorated insulin sensitivity in diet-induced ( 17,20,21 ), genetic (22)(23)(24), and chemical-promoted ( 7,22 ) diabetic model animals. Moreover, in HFD-fed mice, dietary quercetin could normalize the levels of proinfl ammatory TNF-␣ and interleukin-6 (IL-6) ( 20,23,25 ) and anti-infl ammatory adiponectin ( 17,20 ) in blood and/or WAT, suppress infl ammatory cells' infi ltration into liver and heart ( 6 ), and alter hepatic infl ammatory response gene expression ( 6, 19-21, 25, 26 ) and activity ( 26 ). However, more evidence is needed regarding whether quercetin alleviates ATM infiltration and inflammation in HFD-fed mice.…”

Pharmacological Applications of Quercetin and its Derivatives: A Short Review

“…In vivo study in non-alcoholic steatohepatitis gerbils, it has been reported that gerbils which had been orally administered with quercetin showed a decreased deposition of fats in liver cells, thereby protecting liver cells from fibrosis [40]. Moreover, in vivo study in mice relating to the hepatoprotective mechanism of quercetin reported that it is the hemeoxygenase 1 that triggers the function of quercetin against induced hepatotoxicity; hepatoprotectivity was then observed by the decrease in plasma concentration of alanine aminotransferase [41].…”

“…Antioxidant activity [4], [5], [6], [7], [8] [16], [17], [18], [19], [20], [21], [22] Anticancer activity [2], [23], [24], [25], [26] Cardiovascular protection [4], [27], [28], [29], [30] Antimicrobial activity [31], [32], [33] Anti-inflammatory activity [34], [35], [36], [37], [38], [39] Hepatoprotective activity [40], [41], [42] …”