DietaryD‐psicose, a C‐3 epimer ofD‐fructose, suppresses the activity of hepatic lipogenic enzymes in rats

Abstract

D-Psicose (D-ribo-2-hexulose), a C-3 epimer of D-fructose, is present in small quantities in commercial carbohydrate complexes or agricultural products. Wistar male rats were fed experimental diets which consisted of 5% D-psicose, cellulose, D-fructose or D-glucose for 28 days. Abdominal adipose tissue weight was significantly lower (P < 0.05) in rats fed the D-psicose diet than in rats fed a D-fructose and D-glucose diets, even though the four dietary groups were offered the same amount throughout the experimental period. Fatty acid synthase and glucose 6-phosphate dehydrogenase activities in the liver were significantly lower (P < 0.05) in rats fed the D-psicose diet than in rats fed the D-fructose and D-glucose diets. However, lipoprotein lipase activities in the heart, soleus muscle and perirenal adipose tissue were the same. These results suggest that a supplement of D-psicose in the diet suppresses hepatic lipogenic enzyme activities. The lower abdominal fat accumulation in rats fed a D-psicose diet might result from lower lipogenesis in the liver.

Comparison of Anti-Obesity Effect between Two Types of Syrup Containing Rare Sugars in Wistar Rats

“…We also showed that RSS reduced abdominal fat accumulation and serum glucose, insulin, and leptin levels in rats compared to HFCS (18). In our previous study, d-allulose suppressed lipogenic enzymatic activities in the liver compared to glucose or fructose in rats (19,20). Thus, RSS containing d-allulose seem to be effective in preventing body fat accumulation and obesity partly via lowered lipogenic enzymatic activities.…”

Effects of Supplemental D-Psicose on Glucose Tolerance and Serum Adipocytokine Levels in Rats Fed a High-Fat Diet or a Low-Fat Diet

“…Since serum adipocytokines are secreted from adipose tissues, it is pertinent that D-psicose influenced neither adipose tissue weights nor serum levels of adipocytokines. We previously demonstrated that D-psicose provides no energy in rats (3), and that intra-abdominal adipose tissue weight was not different between the diets with 5% D-psicose and cellulose after 28 days (17). Moreover, we previously reported that 5% D-psicose supplementation did not alter gene expression of uncoupling protein-1 and b 3 -adrenergic receptor in the brown adipose tissue, which is main tissue of diet-induced thermogenesis (30).…”

“…We have suggested that D-psicose is partly absorbable in the digestive tract (16) and a 5% D-psicose supplement is enough to suppress hepatic lipogenic enzyme activity and reduce intra-abdominal fat accumulation compared to D-glucose or D-fructose in rats (17,18). If dietary D-psicose influences serum adipocytokines, Dpsicose may be a new functional monosaccharide with anti-diabetic action.…”

Effect of a Fermented Brown Rice Extract on the Gastrointestinal Function in Methotrexate-Treated Rats

“…However, the reason for the results caused by feeding BRF are is not yet clear, except for the fiber content. Such food ingredients as resistant oligosaccharide, 26) D-psicose, 27) and polyphenols 28) have caused the protection of shortchain fatty acids and hypertrophy in the cecum. The prebiotic effects by BRF including or excluding fiber need to be investigated.…”