Dietary supplementation of flaxseed oil ameliorates the effect of cisplatin on rat kidney

Naqshbandi, Ashreeb; Rizwan, Sana; Khan, Farah

doi:10.1016/j.jff.2012.11.002

Cited by 38 publications

(17 citation statements)

References 53 publications

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“…The C-PC (Lt number 044/ [13][14] used was a generous gift from Valensa International (Orlando, FL, USA). CP was obtained from Aldrich (Cat.…”

Section: Reagentsmentioning

confidence: 99%

“…CP is a potent antineoplastic agent discovered in the laboratory of Barnett Rosenberg in 1965 [12]. It is widely used worldwide for cancer treatment, including testicular, ovarian, bladder, neck, endometrium, non-small cell lung adenocarcinoma, melanoma, penile, and adrenal carcinoma [13,14]. However, its therapeutic use is limited mainly because it is capable to induce renal damage.…”

Section: Introductionmentioning

confidence: 99%

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C-phycocyanin prevents cisplatin-induced mitochondrial dysfunction and oxidative stress

et al. 2015

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The potential of C-phycocyanin (C-PC) to prevent cisplatin (CP)-induced kidney mitochondrial dysfunction was determined in CD-1 male mice. The CP-induced mitochondrial dysfunction was characterized by ultrastructural abnormalities and by decrease in the following parameters in isolated kidney mitochondria: adenosine diphosphate (ADP)-induced oxygen consumption (state 3), respiratory control ratio, ADP/oxygen (ADP/O) ratio, adenosine triphosphate synthesis, membrane potential, calcium retention, glutathione (GSH) content, and activity of respiratory complex I, aconitase, catalase, and GSH peroxidase. These mitochondria also showed increase in hydrogen peroxide production, malondialdehyde, and 3-nitrotyrosine protein adducts content. The above-described changes, as well as CP-induced nephrotoxicity, were attenuated in mice pretreated with a single injection of C-PC. Our data suggest that the attenuation of mitochondrial abnormalities is involved in the protective effect of C-PC against CP-induced nephrotoxicity. This is the first demonstration that C-PC pretreatment prevents CP-induced mitochondrial dysfunction in mice.

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“…The C-PC (Lt number 044/ [13][14] used was a generous gift from Valensa International (Orlando, FL, USA). CP was obtained from Aldrich (Cat.…”

Section: Reagentsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

C-phycocyanin prevents cisplatin-induced mitochondrial dysfunction and oxidative stress

et al. 2015

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“…Antioxidants that prevent cellular damage induced by reactive oxygen species (ROS) and reactive nitrogen species (RNS) are considered to be effective therapeutic agents for kidney diseases (Djamali, 2007;Naqshbandi, Rizwan, & Khan, 2013;Verzola et al, 2004). Therefore, to elucidate the renoprotective effect of protocatechuic acid, we investigated the protective effects of protocatechuic acid against cisplatin-induced oxidative stress in cultured kidney cells and in rats.…”

Section: Introductionmentioning

confidence: 99%

Protective effects of protocatechuic acid against cisplatin-induced renal damage in rats

Yamabe

Park

Lee

et al. 2015

Journal of Functional Foods

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A B S T R A C TThe protective effects of an extract from bitter melon (Momordica charantia, Cucurbitaceae) against oxidative stress was previously reported and found that protocatechuic acid (PCA) was one of the major phenolic constituents in the extract. The renoprotective effect of PCA from bitter melon was investigated in the present study. In the LLC-PK1 cellular model, the decline in cells viabilities induced by oxidative stress, such as that induced by sodium nitroprusside, pyrogallol, and SIN-1, was significantly and dose-dependently inhibited by PCA.In the in vivo model, the cisplatin-treated rats showed increased plasma levels of creatinine, decreased creatinine clearance, and increased urine protein levels. However, these parameters related to renal dysfunction were markedly attenuated by PCA treatment. Administration of PCA resulted in remarkable improvement in the histological appearance and reduction in tubular cell damage in the cisplatin-treated rat kidneys. Moreover, the elevated levels of pro-caspase-3 induced by cisplatin in rat kidneys were down-regulated by PCA co-treatment. These results suggest that PCA has protective activity against anticancer drug-induced oxidative nephrotoxicity.

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“…The acids have an important role in the brain, constituting a component of the phospholipids of cell membranes, and, in particular, high levels of them occur in the tissue of the central nervous system and the retina of the eye. They affect the regulation of the cardiovascular system, blood pressure, immune response, inflammatory processes, the development of cancers, and the functioning of the kidneys . A rich source of PUFA, including mostly omega‐3, is linseed oil, so it should be more widely used as an edible fat in order to maintain an appropriate physiological balance between fatty acids of the n‐6 and n‐3 family.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant activity and anti‐inflammatory effect of fruit extracts from blackcurrant, chokeberry, hawthorn, and rosehip, and their mixture with linseed oil on a model lipid membrane

Strugała¹,

Gładkowski²,

Kucharska

et al. 2015

Euro J Lipid Sci & Tech

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The study of ethanol extracts as potential dietary supplements has shown that extracts of chokeberry (IC 50 24.6 mg/mL) and, to a lesser extent, blackcurrant, rosehip, and hawthorn (IC 50 30.9, 33.5, and 45.9 mg/mL) are good antioxidants in relation to UVB-oxidized phosphatidylcholine liposomes. All tested fruit extracts protect the bilayer against oxidation by reducing fluidity of the membrane hydrophilic/hydrophobic region (in the presence of extracts the generalized polarization of the Laurdan probe and fluorescence anisotropy of DPH and TMA-DPH increased). The major phenolic compounds were analyzed by high-performance liquid chromatography-mass spectrometry (HPLC/MS). The extracts caused inhibition of the pro-inflammatory enzymes cyclooxygenase-1 and cyclooxygenase-2, the highest for blackcurrant (77.6 and 70.5%, respectively) and rosehip (64.9 and 72.5%). Another aspect of the research demonstrated antioxidant and antiradical stability of the extracts during 12-month storage. With the exception of hawthorn, they stabilized the profile of unsaturated fatty acids of linseed oil during storage. The investigated fruit extracts in combination with polyunsaturated fatty acids may provide stable and effective dietary anti-inflammatory and antioxidant benefits.Practical applications: By combining two different groups of bioactive compounds (fruit extracts þ omega-3 fatty acids), a new attractive product has been obtained of broad biological activity, which could potentially be useful as a functional food ingredient. The study enabled us to specify the regions where fruit extracts become imbedded in the membrane, based on changes in physical parameters induced in the regions, and will allow us to explain at the molecular level a possible way to protect lipid membranes against attack by free radicals.Keywords: Anti-inflammatory activity / Dietary supplements / Liposomal antioxidants / Membrane fluidity / Profile of unsaturated fatty acids of linseed oil

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Dietary supplementation of flaxseed oil ameliorates the effect of cisplatin on rat kidney

Cited by 38 publications

References 53 publications

C-phycocyanin prevents cisplatin-induced mitochondrial dysfunction and oxidative stress

C-phycocyanin prevents cisplatin-induced mitochondrial dysfunction and oxidative stress

Protective effects of protocatechuic acid against cisplatin-induced renal damage in rats

Antioxidant activity and anti‐inflammatory effect of fruit extracts from blackcurrant, chokeberry, hawthorn, and rosehip, and their mixture with linseed oil on a model lipid membrane

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