Dietary Supplementation of Rumen-Protected Methionine, Lysine and Choline Improves Lactation Performance and Blood Metabolic Profile of Karan-Fries Cows

Amrutkar, S.A.; Pawar, Sharad; Thakur, Shubham; Kewalramani, Neelam; Mahesh, M. S.

doi:10.1007/s40003-015-0178-2

Cited by 15 publications

(22 citation statements)

References 25 publications

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“…This partially agrees with de Veth et al (2016) who reported that arterial concentrations of LPC were increased in lactating cows fed RPC from ReaShure. In addition, plasma concentrations of PC (Amrutkar et al, 2015) and PL containing choline (Pinotti et al, 2004) were increased in lactating dairy cows fed supplemental RPC ions although the choline sources fed in those studies were not ReaShure. Abomasal infusion of choline chloride did not change the plasma concentration of PC (Sharma and Erdman, 1989;de Veth et al, 2016) in lactating dairy cows but cows fed RPC ions tended (P = 0.06) to have greater plasma concentrations of PC compared with cows abomasally infused with choline chloride (de Veth et al, 2016).…”

Section: Choline Biomoleculesmentioning

confidence: 86%

“…Expression of mRNA of microsomal triglyceride transport protein and apoprotein B100, both of which promote assembly of VLDL in the cytosol of cells, was increased in hepatic tissue collected at 1, 3, and 6 wk postpartum from multiparous Holstein cows fed RPC ions (Goselink et al, 2013). In support, concentrations of VLDL (Amrutkar et al, 2015) and apoprotein B100 in plasma were increased in periparturient dairy cows fed RPC ions (Sun et al, 2016). The lipotropic effect of RPC ions was accompanied by decreasing concentration of haptoglobin in the bloodstream (Table 7).…”

Section: Hepatic Tag and Glycogenmentioning

confidence: 90%

“…7, 2018 (Table 7). Others have reported increased (Janovick Guretzky et al, 2006 in the prepartum period; Elek et al, 2013;Amrutkar et al, 2015), decreased (Mohsen et al, 2011), or no effect (Janovick Guretzky et al, 2006 in the postpartum period; Xu et al, 2006;Ardalan et al, 2011) of RPC ion supplementation on circulating concentrations of TAG in dairy cows. This lack of agreement among laboratories may reflect different sampling times in relation to feeding, fewer samples collected than collected in the current experiment, and different amounts of fat intake.…”

Section: Fat Loadingmentioning

confidence: 99%

“…Tallow supplementation dramatically increased concentrations of plasma TAG and RPC supplementation did not increase TAG concentrations further. Feeding RPC ions increased plasma concentrations of TAG in dairy cows fed diets containing less than 3.5% ether extract on a DM basis (Janovick Guretzky et al, 2006, prepartum;Amrutkar et al, 2015). However, when diets contained more fat from whole cottonseed, supplementation of RPC ions had no effect on plasma TAG (Janovick Guretzky et al, 2006 postpartum;Xu et al, 2006;Ardalan et al, 2011).…”

Section: Fat Loadingmentioning

confidence: 99%

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Feeding increasing amounts of ruminally protected choline decreased fatty liver in nonlactating, pregnant Holstein cows in negative energy status

Zenobi

Scheffler

Zuniga

et al. 2018

Journal of Dairy Science

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The objectives were to determine the optimal feeding amount of choline in a ruminally protected form to reduce the triacylglycerol (TAG) concentration in liver and to increase TAG in blood plasma of dairy cows. Pregnant, nonlactating multiparous Holstein cows (n = 77) were blocked by body condition score (3.59 ± 0.33) and assigned to treatment at 64 ± 10 d before calculated calving date. Dietary treatments were top-dressing of 0, 30, 60, 90, or 120 g/d of ruminally protected choline (RPC; Balchem Corp., New Hampton, NY) ions to supply the equivalent of 0, 6.5, 12.9, 19.4, and 25.8 g/d of choline ions. Diets were formulated to exceed nutrient requirements for maintenance and pregnancy and fed in ad libitum amounts for the first 5 d. From d 6 to 15, cows were restricted to consume approximately 31% of their net energy requirements to simulate early lactating cows in negative energy balance. Methionine intake was maintained throughout each 15-d period. Liver was biopsied at 5 and 14 d and analyzed for TAG and glycogen. Blood was sampled on d 5 and 14 and plasma analyzed for glucose, insulin, cholesterol, β-hydroxybutyrate, long-chain fatty acids, and haptoglobin. On d 14, a mixture of saturated long-chain fatty acids, ground corn, and dried molasses (50:37:13) was offered (908 g, as-is basis) 10 h after the single daily feeding. Blood samples were collected for 19 h and plasma analyzed for TAG and cholesterol to assess apparent absorption of dietary fat. Mean dry matter intake and energy balance decreased from means of 9.5 to 3.3 kg/d and from 0.6 to -9.2 Mcal of net energy for lactation/d during the ad libitum and restricted feeding periods, respectively. Plasma concentrations of the lipid-soluble choline biomolecules, namely total phosphatidylcholines, total lysophosphatidylcholines, and sphingomyelin, increased with choline supplementation. Feed restriction increased plasma concentrations of β-hydroxybutyrate and free long-chain fatty acids, whereas those of glucose, insulin, and total cholesterol decreased. During feed restriction, concentration of hepatic TAG and plasma haptoglobin decreased linearly, whereas concentration of hepatic glycogen tended to increase quadratically with increasing intake of RPC. After fat supplementation, mean plasma concentration of TAG increased by an average of 21% with intake of RPC ions, peaking at intakes of ≥6.5 g/d of RPC ion. In summary, feeding RPC ions to cows in negative energy balance had increasing lipotropic effects on the liver when consumed up to 25.8 g/d, whereas feeding only 6.5 g/d increased concentrations of hepatic glycogen and TAG in the blood.

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Section: Choline Biomoleculesmentioning

confidence: 86%

Section: Hepatic Tag and Glycogenmentioning

confidence: 90%

Section: Fat Loadingmentioning

confidence: 99%

Section: Fat Loadingmentioning

confidence: 99%

See 2 more Smart Citations

Feeding increasing amounts of ruminally protected choline decreased fatty liver in nonlactating, pregnant Holstein cows in negative energy status

Zenobi

Scheffler

Zuniga

et al. 2018

Journal of Dairy Science

View full text Add to dashboard Cite

show abstract

“…Results indicated an interaction between RPC and BCS at the beginning of the experiment and responses to choline were observed in cows with BCS of at least 4.00. Although some have suggested that the benefits of choline might be present primarily in cows at greater risk of fatty liver, others have shown greater milk yield in cows supplemented with RPC even when prepartum BCS was moderate, around 3.00 (Amrutkar et al, 2015). Indeed, supplementation with RPC tended to increase yields of fat and 3.5% FCM in cows starting the experiment prepartum with BCS of 3.50 without a reduction in hepatic triacylglycerol (Piepenbrink and Overton, 2003).…”

Section: Introductionmentioning

confidence: 98%