Differences in aggressive behavior and in the mesocorticolimbic DA system between A/J and BALB/cJ mice

Couppis, Maria H.; Kennedy, Craig H.; Stanwood, Gregg D.

doi:10.1002/syn.20545

Cited by 34 publications

(29 citation statements)

References 54 publications

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“…However, surprisingly, BALB/cByJ males had a lower attack latency than BALB/cJ males [strain: F(1, 21) = 9.6, p<0.01)] and a higher number of attacks compared to BALB/cJ males [strain: F(1, 21) = 9.6, p<0.01)] (Figure 3A, B). This was opposite to the difference that has been reported by many prior publications (Ciaranello et al 1974; Kessler et al 1977; Couppis et al 2008), including a relatively recent study by our lab (Velez et al 2010). …”

Section: Resultscontrasting

confidence: 99%

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Phenotypic instability between the near isogenic substrains BALB/cJ and BALB/cByJ

et al. 2014

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Closely related substrains of inbred mice often show phenotypic difzferences that are presumed to be caused by recent mutations. The substrains BALB/cJ and BALB/cByJ, which were separated in 1935, have been reported to show numerous highly significant behavioral and morphological differences. In an effort to identify some of the causal mutations, we phenotyped BALB/cJ and BALB/cByJ mice as well as their F1, F2, and N2 progeny for behavioral and morphological phenotypes. We also generated whole genome sequence data for both inbred strains (∼3.5× coverage) with the intention of identifying polymorphic markers to be used for linkage analysis. We observed significant differences in body weight, the weight of the heart, liver, spleen and brain, and corpus callosum length between the two substrains. We also observed that BALB/cJ animals showed greater anxiety-like behavior in the open field test, less depression-like behavior in the tail suspension test, and reduced aggression compared to BALB/cByJ mice. Some but not all of these physiological and behavioral results were inconsistent with prior publications. These inconsistencies led us to suspect that the differences were due to, or modified by, non-genetic factors. Thus, we did not perform linkage analysis. We provide a comprehensive summary of the prior literature about phenotypic differences between these substrains as well as our current findings. We conclude that many differences between these strains are unstable and therefore ill-suited to linkage analysis; the source of this instability is unclear. We discuss the broader implications of these observations for the design of future studies.

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Section: Resultscontrasting

confidence: 99%

“…They have been reported to exhibit high levels of attack behavior compared to BALB/cByJ males (Ciaranello et al 1974; Kessler et al 1977; Couppis et al 2008; Velez et al 2010; Dow et al 2011). Here we used the RI paradigm to measure aggression.…”

Section: Resultsmentioning

confidence: 99%

Phenotypic instability between the near isogenic substrains BALB/cJ and BALB/cByJ

et al. 2014

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“…Interestingly, Balb/cJ mice have increased DA and DA metabolites in nucleus accumbens and prefrontal cortex, as well as decreased levels of 5-HT and 5-HIAA in comparison with A/J mice. Balb/cJ mice also show increased DA D 2 binding in nucleus accumbens in comparison with A/J mice (Couppis et al, 2008). These data are similar to findings in ill and recovered AN patients, whom exhibit increased D2 binding potentials , as well as decreases in 5-HIAA (Kaye et al, 1988;Kaye et al, 1991).…”

Section: Discussionsupporting

confidence: 65%

Olanzapine, but Not Fluoxetine, Treatment Increases Survival in Activity-Based Anorexia in Mice

Klenotich

Seiglie

McMurray

et al. 2012

Neuropsychopharmacol

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Anorexia nervosa (AN) is an eating disorder characterized by extreme hypophagia, hyperactivity, and fear of weight gain. No approved pharmacological treatments exist for AN despite high mortality rates. The activity-based anorexia (ABA) phenomenon models aspects of AN in rodents, including progressive weight loss, reduced food intake, and hyperactivity. First, we optimized the ABA paradigm for mice. We compared mouse strains (Balb/cJ, A/J) for susceptibility with ABA, and evaluated the effects of different food access durations (2, 4, 6, 8, and 10 h) on ABA parameters. Balb/cJ mice exhibited significantly shorter survival time (days until 25% bodyweight loss) in the ABA paradigm compared with A/J mice. Furthermore, 6 h of food access reduced survival in mice housed with wheels without reducing survival in mice housed without wheels. We then evaluated the effects of chronic treatment with fluoxetine (4 weeks) or subchronic treatment with olanzapine (OLZ) (1 week) on ABA in BALB/cJ mice. OLZ (12 mg/kg/day) significantly increased survival and reduced food anticipatory activity (FAA). However, OLZ did not alter food intake or running wheel activity during ad-lib feeding (baseline) or restriction conditions, or in mice housed without wheels. Fluoxetine (18 mg/kg/day) increased food intake and reduced FAA, but did not alter survival. Here, we report for the first time that OLZ, but not fluoxetine, reduces ABA in mice. Our findings indicate further need for clinical investigations into the effects of OLZ, but not selective serotonin reuptake inhibitors, on core features of AN.

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“…Social function in which DA signaling has been implicated can be expressed as variable forms from an individual level of behavior such as pair bonding (Aragona et al, 2006), parent-offspring attachment (Gammie et al, 2008), affiliative relationship (Cervenka et al, 2010), aggression (Couppis et al, 2008), play (Achterberg et al, 2014), social recognition and memory (Millan et al, 2007), and vocal communication (Leblois et al, 2010; Willuhn et al, 2014), and prosocial behavior (Saez et al, 2015), to a social structural level such as social network (Fowler et al, 2011) and social hierarchy (Nader et al, 2012). …”

Section: Roles Of Da In Social Functionmentioning

confidence: 99%

Dopamine in socioecological and evolutionary perspectives: implications for psychiatric disorders

2015

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Dopamine (DA) transmission in brain areas such as the prefrontal cortex (PFC) and nucleus accumbens (NAcc) plays important roles in cognitive and affective function. As such, DA deficits have been implicated in a number of psychiatric disorders such as schizophrenia and attention deficit/hyperactivity disorder (ADHD). Accumulating evidence suggests that DA is also involved in social behavior of animals and humans. Although most animals organize and live in social groups, how the DA system functions in such social groups of animals, and its dysfunction causes compromises in the groups has remained less understood. Here we propose that alterations of DA signaling and associated genetic variants and behavioral phenotypes, which have been normally considered as “deficits” in investigation at an individual level, may not necessarily yield disadvantages, but even work advantageously, depending on social contexts in groups. This hypothesis could provide a novel insight into our understanding of the biological mechanisms of psychiatric disorders, and a potential explanation that disadvantageous phenotypes associated with DA deficits in psychiatric disorders have remained in humans through evolution.

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Differences in aggressive behavior and in the mesocorticolimbic DA system between A/J and BALB/cJ mice

Cited by 34 publications

References 54 publications

Phenotypic instability between the near isogenic substrains BALB/cJ and BALB/cByJ

Phenotypic instability between the near isogenic substrains BALB/cJ and BALB/cByJ

Olanzapine, but Not Fluoxetine, Treatment Increases Survival in Activity-Based Anorexia in Mice

Dopamine in socioecological and evolutionary perspectives: implications for psychiatric disorders

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