Differences in cytokine levels between the nasal polyps of adolescents with local allergic and adolescents with allergic or nonallergic rhinitis

Choi, Young Jin; Kang, Ha-Na; Kim, Joo-Hwa; Oh, Jae‐Won; Jeong, Jin Hyeok

doi:10.2500/aap.2018.39.4135

Cited by 4 publications

(3 citation statements)

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“…Although IL-5 and RANTES could be increased in AR, it was not directly related to nNO, so measurement of cytokine and chemokine in nasal secretion is helpful for the evaluation of AR, but it would be difficult to use as an indirect method of evaluation of nNO. 22 Arnal et al 18 showed that nNO production increased regardless of the presence or absence of symptoms in AR due to the persistent inflammatory response of the nasal mucosa. However, it has been reported that nNO levels can be reduced when symptoms are severe and long-lasting.…”

Section: Discussionmentioning

confidence: 99%

Correlation between nasal nitric oxide and its metabolites, RANTES, IL-5 in allergic rhinitis

et al. 2021

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There have been two measurement methods for nasal nitric oxide (nNO): direct measurement of nNO and indirect measurement of NO metabolites or the NO synthase enzyme. The aim of this study is to investigate the difference in nNO between allergic rhinitis (AR) patients and the correlation of the direct measurement of nNO and indirect measurement of nNO metabolites, RANTES, and IL-5. Fifteen patients with AR, 15 patients with septal deviation as a control group were enrolled. We measured the nNO level using a chemiluminescence analyzer and the amount of NO metabolites, RANTES, and IL-5 in nasal lavage fluid using the ELISA method. Nasal NO levels were significantly higher in AR than the control (195.7 ± 39.6 vs 159.4 ± 25.8 ppb, P = 0.027). NO metabolites, IL-5, and RANTES levels were higher in AR, but there was no statistically significant difference. There was no significant correlation between nNO and nNO metabolites, RANTES, IL-5, and clinical parameters except for the olfactory test score in AR. There was a negative correlation between nNO and the olfactory test score in AR ( r = −0.590, P = 0.034). Nasal NO concentration increased in AR. However, nNO metabolites and IL-5, RANTES in nasal secretion did not show any correlation with nNO. Direct measurement of nNO could be a potentially useful biomarker of AR compared to indirect measurement of NO metabolites, cytokines, and chemokines in nasal secretion.

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Section: Discussionmentioning

confidence: 99%

Correlation between nasal nitric oxide and its metabolites, RANTES, IL-5 in allergic rhinitis

et al. 2021

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“…Presence of allergic rhinitis (AR) was evaluated in all enrolled patients at the beginning of the study on the basis of clinical symptoms, a sufficiently high total IgE serum concentration, and positivity in a skin prick (SPT) or serum allergen test, such as ImmunoCAP system. 10,11 Patients with a positive SPT (wheal diameter !3 mm larger than that of negative control after 15 min) and high titer (!2 positivity; !0.70 IU/ml) of IgE antibodies specific for at least one antigen were diagnosed with AR. All enrolled subjects were evaluated with respect to the eosinophilic cationic protein (ECP) level and eosinophil number.…”

Section: Study Participantsmentioning

confidence: 99%

Expression Pattern of HMGB1 Differs Between Eosinophilic Chronic Rhinosinusitis With Nasal Polyp and Non-Eosinophilic Chronic Rhinosinusitis With Nasal Polyp: A Preliminary Study

Min

Kim

2020

Am J Rhinol�Allergy

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Background Eosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP) is histologically distinct from non-eosinophilic CRSwNP (NECRSwNP) and exhibits a high frequency of recurrence. The differences between the pathogenesis of ECRSwNP and NECRSwNP are not well-characterized. HMGB1 has been implicated in the pathogenesis of CRSwNPs; however, its precise contributions to ECRSwNP and NECRSwNP have not been established. Objective We evaluated the role of HMGB1 in the pathogenesis of ECRSwNP. Methods A total of 26 nasal polyps (NPs) from patients with ECRSwNP and NECRSwNP who underwent endoscopic sinus surgery were obtained. Western blotting and immunohistochemistry were performed to compare the HMGB1 levels between the NPs from ECRS and NECRS. A multiplex cytokine assay was performed to evaluate the levels of other cytokines and chemokines in exudates in the NPs. Nasal lavage fluids were used to evaluate extracellular HMGB1 levels using enzyme-linked immunosorbent assay. Results HMGB1 expression in the NPs was higher in ECRSwNP than in NECRSwNP. The level of HMGB1 in the exudate within the NPs was significantly higher in ECRSwNP than in NECRSwNP. Furthermore, HMGB1 levels in nasal lavage fluids from ECRSwNP were higher than those from NECRSwNP. We found that HMGB1 levels in the exudate in NPs and in nasal lavage fluids effectively differentiate ECRSwNP from NECRSwNP. Conclusion Our results suggest that a high level of HMGB1 in NPs is an important factor for differentiating ECRSwNP from NECRSwNP. HMGB1 may play a role in the development of ECRSwNP and should be further evaluated.

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“…Its pathogenesis is largely unknown. In this issue, Choi et al 12 evaluated the cytokine profile of nasal polyps derived from adolescents with LAR in comparison with the cytokine profile of nasal polyps derived from adolescents with either allergic or nonallergic rhinitis. The authors performed immunoassays by using polyp tissue homogenates to quantify the levels of RANTES (regulated on activation of normal T-cell expressed and secreted), tumor necrosis factor alpha, interleukin 5, and sera to assess total IgE and eosinophil cationic protein values.…”

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confidence: 99%

Children are not small adults

Bellanti¹,

Settipane²

2018

allergy asthma proc

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Differences in cytokine levels between the nasal polyps of adolescents with local allergic and adolescents with allergic or nonallergic rhinitis

Abstract: Results of our study indicated that RANTES may play an important role and contribute to allergic reaction in LAR, and RANTES may be related to the pathogenesis of LAR.

Cited by 4 publications

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Correlation between nasal nitric oxide and its metabolites, RANTES, IL-5 in allergic rhinitis

Correlation between nasal nitric oxide and its metabolites, RANTES, IL-5 in allergic rhinitis

Expression Pattern of HMGB1 Differs Between Eosinophilic Chronic Rhinosinusitis With Nasal Polyp and Non-Eosinophilic Chronic Rhinosinusitis With Nasal Polyp: A Preliminary Study

Children are not small adults

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