Different effects of scopolamine on learning, memory, and nitric oxide metabolite levels in hippocampal tissues of ovariectomized and Sham-operated rats

Azizi-Malekabadi, Hamid; Hosseini, Mahmoud; Soukhtanloo, Mohammad; Sadeghian, Reihaneh; Fereidoni, Masoud; Khodabandehloo, Fatemeh

doi:10.1590/s0004-282x2012000600012

Cited by 39 publications

(17 citation statements)

References 32 publications

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“…NO metabolites (NO 2 /NO 3 ) were measured according to the Griess reagent methods. In brief, after adding 100 μl supernatant to the Griess reagent, contents were transferred to a 96-well flat-bottomed micro-plate and absorbance was read at 520 nm using a micro-plate reader, and the final values were calculated from standard calibration plots [27][28][29].…”

Section: Determination Of Mda Total Thiol and No Metabolitesmentioning

confidence: 99%

Inducible nitric oxide inhibitor aminoguanidine, ameliorates deleterious effects of lipopolysaccharide on memory and long term potentiation in rat

et al. 2016

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Section: Determination Of Mda Total Thiol and No Metabolitesmentioning

confidence: 99%

Inducible nitric oxide inhibitor aminoguanidine, ameliorates deleterious effects of lipopolysaccharide on memory and long term potentiation in rat

et al. 2016

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“…The contents were then vortex-mixed and centrifuged, and the supernatants were transferred to a 96-well flat-bottomed microplate. Absorbance was read at 520 nm using a microplate reader, and the final values were calculated from standard calibration plots 19,20 .…”

Section: Determination Of No Metabolites (No 2 /No 3 )mentioning

confidence: 99%

Lipopolysaccharide-induced memory impairment in rats is preventable using 7-nitroindazole

Anaeigoudari

Shafei

Soukhtanloo

et al. 2015

Arq. Neuro-Psiquiatr.

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Inflammation and oxidative stress have important roles in memory impairment. The effect of 7-nitroindazole (7NI) on lipopolysaccharide (LPS)-induced memory impairment was investigated. Rats were used, divided into four groups that were treated as follows: (1) control (saline); (2) LPS; (3) 7NI-LPS; and (4) 7NI before passive avoidance (PA). In the LPS group, the latency for entering the dark compartment was shorter than in the controls (p < 0.01 and p < 0.001); while in the 7NI-LPS group, it was longer than in the LPS group (p < 0.01 and p < 0.001). Malondialdehyde (MDA) and nitric oxide (NO) metabolite concentrations in the brain tissues of the LPS group were higher than in the controls (p < 0.001 and p < 0.05); while in the 7NI-LPS group, they were lower than in the LPS group (p < 0.001 and p < 0.05, respectively). The thiol content in the brain of the LPS group was lower than in the controls (p < 0.001); while in the 7NI-LPS group, it was higher than in the LPS group (p < 0.001). It is suggested that brain tissue oxidative damage and NO elevation have a role in the deleterious effects of LPS on memory retention that are preventable using 7NI.

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“…Dano oxidativo ao tecido cerebral como possível mecanismo de efeito deletério da alta dose crônica de estradiol no aprendizado e memória de ratas ooforectomizadas Ovarian hormones affect a wide variety of nervous system functions especially the cognitive abilities, learning and memory 1 . It has been suggested that estrogen may prevent cognitive impairments due to aging 2 .…”

Section: Brain Tissue Oxidative Damage As a Possible Mechanism For Thunclassified

Brain tissue oxidative damage as a possible mechanism for the deleterious effect of a chronic high dose of estradiol on learning and memory in ovariectomized rats

Khodabandehloo

Hosseini

Rajaei

et al. 2013

Arq. Neuro-Psiquiatr.

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In addition to antioxidative effects, estrogens also exert pro-oxidative actions. The effect of chronic administration of a high dose of estradiol valerate on Morris water maze tasks and brain tissues oxidative damage was investigated. The Sham-Est and OVX-Est groups were treated with estradiol valerate (4 mg/kg) for 12 weeks. Escape latency and traveled path in the Sham-Est and OVX-Est groups were significantly higher than in the Sham and OVX groups (p<0.01 and p<0.001). In the probe trial, the animals of the Sham-Est and OVX-Est groups spent lower time in Q 1 compared to Sham and OVX groups (p<0.05 and p<0.001). In Sham-Est and OVX-Est groups, the brain tissue total thiol concentration was significantly lower, and malondialdehyde (MDA) concentrations were higher than in the Sham and OVX groups (p<0.05 and p<0.001). It is concluded that administration of high exogenous levels of estradiol impairs performance and enhances oxidative stress.Key words: learning, memory, ovariectomy, estradiol, morris water maze, oxidative stress. RESUMOAlém dos efeitos antioxidantes, os estrógenos também têm ação pró-oxidativa. Foi investigado o efeito da administração crônica de alta dose de valereato de estradiol no desempenho do labirinto aquático de Morris e o dano oxidativo ao tecido cerebral. Os grupos Sham-Est e OVX-Est foram tratados com valereato de estradiol (4 mg/kg) por 12 semanas. O tempo de latência para escapada e o caminho percorrido foram significativamente maiores nos grupos Sham-Est e OVX-Est em relação aos grupos Sham e OVX (p<0,01 e p<0,001). No estudo probe, os animais dos grupos Sham-Est e OVX-Est levaram menos tempo no Q 1 em comparação aos grupos Sham e OVX (p<0,05 e p<0,001). Nos grupos Sham-Est e OVX-Est, a concentração total de tiol foi significativamente menor, enquanto a concentração de malondialdehydo (MDA) for maior do que aquela dos grupos Sham e OVX (p<0,05 e p<0,001). Concluiu-se que a administração de altas doses de estradiol exógeno compromete o desempenho e aumenta o estresse oxidativo naqueles animais.Palavras-Chave: aprendizado, memória, ovariectomia, estradiol, Labirinto Aquático de Morris, estresse oxidativo.

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Different effects of scopolamine on learning, memory, and nitric oxide metabolite levels in hippocampal tissues of ovariectomized and Sham-operated rats

Cited by 39 publications

References 32 publications

Inducible nitric oxide inhibitor aminoguanidine, ameliorates deleterious effects of lipopolysaccharide on memory and long term potentiation in rat

Inducible nitric oxide inhibitor aminoguanidine, ameliorates deleterious effects of lipopolysaccharide on memory and long term potentiation in rat

Lipopolysaccharide-induced memory impairment in rats is preventable using 7-nitroindazole

Brain tissue oxidative damage as a possible mechanism for the deleterious effect of a chronic high dose of estradiol on learning and memory in ovariectomized rats

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