Different Levels in Alcohol and Tobacco Consumption in Head and Neck Cancer Patients from 1957 to 2013

Abstract

ObjectiveTo provide a precise quantification of the association between alcohol and tobacco consumption trends in head and neck cancer patients over the past 45 years.MethodsWe combined findings from all studies published until March 2014 and evaluated the association between different levels in alcohol and tobacco consumption and head and neck cancers through a meta-analytic approach.ResultsWe included 28 studies involving 13830 patients with head and neck cancer. In patients with alcohol consumption, the pooled odds ratio (OR) and 95% confidence interval (CI) were 1.29(1.06-1.57), 2.67(2.05-3.48) and 6.63(5.02-8.74) for light drinkers, moderate drinkers and heavy drinkers, respectively. In patients with tobacco consumption, the pooled OR and 95% CI were 2.33(1.84-2.95), 4.97(3.67-6.71) and 6.77(4.81-9.53) for light smokers, moderate smokers and heavy smokers, respectively.ConclusionThe increased alcohol and tobacco consumption trends increased the risk of head and neck cancer over the past 45 years. Tobacco consumption was found to be a stronger risk factor for head and neck cancer than alcohol consumption. Thus, the control should be considered to limit the intake of alcohol and tobacco.

The association, clinicopathological significance, and diagnostic value of <em>CDH1</em> promoter methylation in head and neck squamous cell carcinoma: a meta-analysis of 23 studies

“…Alcohol consumption is a known predisposing factor for HNSCC60 and has been shown to induce DNA methylation in oncogenesis 61. In the current study, CDH1 promoter methylation was significantly increased in patients with high alcohol consumption, indicating that it may contribute to HNSCC via the induction of hypermethylation of CDH1 .…”

Attitudes and Parameters Affecting the Behavior Toward Precursor Symptoms of Head and Neck Cancer

“…They also underscore the need for individualized efforts toward combating HNC in socioeconomically disadvantaged populations 15 and stress the importance of public health training and provision of easily available health services in people demonstrating lower educational and socioeconomic status. 16 Finally, tobacco smoking is perceived to be the strongest risk factor for HNC, 17 and even its continuation after treatment has been shown to be an independent negative factor for the prognosis of certain patient categories. 18 The results of the present study suggest that in addition to the well described pathophysiological effects of smoking to the upper aerodigestive tract, its practice may be associated with delayed patient response to hoarseness and thus a more advanced stage of first diagnosis for cancer.…”

TC2 C776G polymorphism studies in patients with oral cancer in the Polish population

“…Other factors are associated with the ability to metabolize carcinogens or repair DNA. Individual susceptibility to cancer may be associated with a particular genotype, which might in turn be associated with metabolic disorders, resulting in increased exposure to carcinogens [34], the most important being aromatic amines. To summarize, oral cancer is known to be associated with smoking and chewing tobacco, the consumption of alcoholic beverages, a diet low in fresh fruits and vegetables, poor oral hygiene and ill-fitting dentures, and, in the case of cancer of the lips, exposure to sunlight [35].…”