Different role of Schisandrin B on mercury-induced renal damage in vivo and in vitro

Stacchiotti, Alessandra; Volti, Giovanni Li; Llombart‐Bosch, Antonio; Schena, Ilaria; Aleo, Maria Francesca; Rodella, Luigi Fabrizio; Rezzani, Rita

doi:10.1016/j.tox.2011.05.005

Cited by 28 publications

(17 citation statements)

References 55 publications

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“…In our study, only nonlactating rats exposed to HgCl 2 exhibited an increase in renal weight followed by a pronounced increase in plasma urea and creatinine levels and urine protein content, which indicates that these animals experienced severe renal injury. In agreement to Stacchiotti et al ,. the histopathological evaluations are fundamental to better understand the renal injury.…”

Section: Discussionsupporting

confidence: 91%

Lactating and nonlactating rats differ to renal toxicity induced by mercuric chloride: the preventive effect of zinc chloride

Favero

Oliveira

Franciscato

et al. 2014

Cell Biochemistry & Function

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This study evaluated the effects of HgCl2 on renal parameters in nonlactating and lactating rats and their pups, as well as the preventive role of ZnCl2 . Rats received 27 mg kg(-1) ZnCl2 for five consecutive days and 5 mg kg(-1) HgCl2 for five subsequent days (s.c.). A decrease in δ-aminolevulinic acid dehydratase (δ-ALA-D) activity in the blood and an increase in urine protein content in renal weight as well as in blood and urine Hg levels were observed in lactating and nonlactating rats from Sal-Hg and Zn-Hg groups. ZnCl2 prevented partially the δ-ALA-D inhibition and the proteinuria in nonlactating rats. Renal Hg levels were increased in all HgCl2 groups, and the ZnCl2 exposure potentiated this effect in lactating rats. Nonlactating rats exposed to HgCl2 exhibited an increase in plasma urea and creatinine levels, δ-ALA-D activity inhibition and histopathological alterations (necrosis, atrophic tubules and collagen deposition) in the kidneys. ZnCl2 exposure prevented the biochemical alterations. Hg-exposed pups showed lower body and renal weight and an increase in the renal Hg levels. In conclusion, mercury-induced nephrotoxicity differs considerably between lactating and nonlactating rats. Moreover, prior exposure with ZnCl2 may provide protection to individuals who get exposed to mercury occupationally or accidentally.

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Section: Discussionsupporting

confidence: 91%

Lactating and nonlactating rats differ to renal toxicity induced by mercuric chloride: the preventive effect of zinc chloride

Favero

Oliveira

Franciscato

et al. 2014

Cell Biochemistry & Function

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“…Chiu et al (2008) suggested the renal beneficial effects of schisandrin B in a rat model of gentamicin-induced nephrotoxicity via enhancing mitochondrial antioxidant status as well as its functional and structural integrity. Recently, Stacchiotti et al (2011) reported that schisandrin B decreased glomerular perfusion and, therefore, alleviated acute oxidative renal failure caused by mercuric chloride. In the current study, we evaluated the effect of SE on DN.…”

Section: Discussionmentioning

confidence: 99%

Schisandra chinensis fruit extract attenuates albuminuria and protects podocyte integrity in a mouse model of streptozotocin-induced diabetic nephropathy

Zhang¹,

Liu²,

Xiong

et al. 2012

Journal of Ethnopharmacology

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“…Type I collagen (newly-formed) fibers appear yellow–red, and type III collagen (constitutive) fibers appear green. For transmission electron microscopy analysis, renal cortex pieces were immersed in 2.5 % glutaraldehyde for 3 h at 4 °C, post-fixed in 1 % osmium tetroxide, and embedded in Epon 812 epoxic mixture as previously reported (Stacchiotti et al 2011). …”

Section: Methodsmentioning

confidence: 99%

Dietary supplementation with essential amino acids boosts the beneficial effects of rosuvastatin on mouse kidney

et al. 2014

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The effects of high-potency statins on renal function are controversial. To address the impact of statins on renal morpho-functional aspects, normotensive young mice were treated with rosuvastatin (Rvs). Moreover, because statins may impair mitochondrial function, mice received either dietary supplementation with an amino acid mixture enriched in essential amino acids (EAAm), which we previously demonstrated to increase mitochondrial biogenesis in muscle or an unsupplemented control diet for 1 month. Mitochondrial biogenesis and function, apoptosis, and insulin signaling pathway events were studied, primarily in cortical proximal tubules. By electron microscopy analysis, mitochondria were more abundant and more heterogeneous in size, with dense granules in the inner matrix, in Rvs- and Rvs plus EAAm-treated animals. Rvs administration increased protein kinase B and endothelial nitric oxide synthase phosphorylation, but the mammalian target of rapamycin signaling pathway was not affected. Rvs increased the expression of sirtuin 1, peroxisome proliferator-activated receptor γ coactivator-1α, cytochrome oxidase type IV, cytochrome c, and mitochondrial biogenesis markers. Levels of glucose-regulated protein 75 (Grp75), B-cell lymphoma 2, and cyclin-dependent kinase inhibitor 1 were increased in cortical proximal tubules, and expression of the endoplasmic reticulum–mitochondrial chaperone Grp78 was decreased. EAAm supplementation maintained or enhanced these changes. Rvs promotes mitochondrial biogenesis, with a probable anti-apoptotic effect. EAAm boosts these processes and may contribute to the efficient control of cellular energetics and survival in the mouse kidney. This suggests that appropriate nutritional interventions may enhance the beneficial actions of Rvs, and could potentially prevent chronic renal side effects.

show abstract

Different role of Schisandrin B on mercury-induced renal damage in vivo and in vitro

Cited by 28 publications

References 55 publications

Lactating and nonlactating rats differ to renal toxicity induced by mercuric chloride: the preventive effect of zinc chloride

Lactating and nonlactating rats differ to renal toxicity induced by mercuric chloride: the preventive effect of zinc chloride

Schisandra chinensis fruit extract attenuates albuminuria and protects podocyte integrity in a mouse model of streptozotocin-induced diabetic nephropathy

Dietary supplementation with essential amino acids boosts the beneficial effects of rosuvastatin on mouse kidney

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