1991
DOI: 10.1016/0885-4505(91)90064-r
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Differential action of thyroid hormones on the activity of certain enzymes in rat kidney and brain

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Cited by 3 publications
(3 citation statements)
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“…Therefore, we hypothesized that hyperthyroidism-induced hyperphagia might be mediated by specific alterations in lipid metabolism in the hypothalamus. 8, 14, 15. Here, we show that hyperthyroidism and T3 increase de novo lipogenesis specifically in the hypothalamus but not in other brain regions.…”
Section: Discussionmentioning
confidence: 54%
See 1 more Smart Citation
“…Therefore, we hypothesized that hyperthyroidism-induced hyperphagia might be mediated by specific alterations in lipid metabolism in the hypothalamus. 8, 14, 15. Here, we show that hyperthyroidism and T3 increase de novo lipogenesis specifically in the hypothalamus but not in other brain regions.…”
Section: Discussionmentioning
confidence: 54%
“…AMPK activity is stimulated in muscle in hyperthyroid states 10-13. In contrast, it is generally assumed that thyroid status does not alter fatty acid biosynthesis in the whole brain 6, 8, 14, 15. However, thyroid hormones might selectively modulate lipid metabolism in discrete areas of the hypothalamus that contribute to energy balance; a theory supported by the recent finding that hypothalamic de novo lipogenesis is involved in the physiological control of feeding 16-20.…”
mentioning
confidence: 99%
“…5 Several studies indicate that thyroid hormones modulate the expression and/or activity of crucial metabolic players in the brain, such as glucose transporters, 6 tyrosine hydroxylases, 7 glutamine synthetase 8 and enzymes of ketone body metabolism. 9 Propylthiouracil (PTU) has been widely used as an antithyroid agent. PTU inhibits both the synthesis of thyroid hormones and the conversion of thyroxine (T4) to its active form triiodothyronine (T3), causing thyroid disorders.…”
Section: Introductionmentioning
confidence: 99%