2006
DOI: 10.1016/j.neuron.2006.04.014
|View full text |Cite
|
Sign up to set email alerts
|

Differential Compartmentalization and Distinct Functions of GABAB Receptor Variants

Abstract: GABAB receptors are the G protein-coupled receptors for the main inhibitory neurotransmitter in the brain, gamma-aminobutyric acid (GABA). Molecular diversity in the GABAB system arises from the GABAB1a and GABAB1b subunit isoforms that solely differ in their ectodomains by a pair of sushi repeats that is unique to GABAB1a. Using a combined genetic, physiological, and morphological approach, we now demonstrate that GABAB1 isoforms localize to distinct synaptic sites and convey separate functions in vivo. At hi… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

27
371
3
6

Year Published

2009
2009
2016
2016

Publication Types

Select...
7

Relationship

4
3

Authors

Journals

citations
Cited by 293 publications
(407 citation statements)
references
References 61 publications
27
371
3
6
Order By: Relevance
“…GABA B receptors are coupled to G proteins and modulate synaptic transmission by activating postsynaptic G protein-gated inwardly rectifying K ϩ channels (GIRK channels, Kir3) and by controlling neurotransmitter release (12,13). Dysfunction of GABA B -mediated synaptic transmission in the central nervous system is proposed to occur in several neurological disorders (13)(14)(15). The partial GABA B R agonist gammahydroxybutyrate (GHB) (16) is used to treat both the excessive sleepiness and cataplexy symptoms of human narcolepsy.…”
Section: Selective Loss Of Gaba B Receptors In Orexin-producing Neuromentioning
confidence: 99%
“…GABA B receptors are coupled to G proteins and modulate synaptic transmission by activating postsynaptic G protein-gated inwardly rectifying K ϩ channels (GIRK channels, Kir3) and by controlling neurotransmitter release (12,13). Dysfunction of GABA B -mediated synaptic transmission in the central nervous system is proposed to occur in several neurological disorders (13)(14)(15). The partial GABA B R agonist gammahydroxybutyrate (GHB) (16) is used to treat both the excessive sleepiness and cataplexy symptoms of human narcolepsy.…”
Section: Selective Loss Of Gaba B Receptors In Orexin-producing Neuromentioning
confidence: 99%
“…Thus, blocking these receptors within the dorsal or ventral CA1 could result in augmented glutamate release from CA3 or possibly entorhinal inputs, resulting in saturated postsynaptic responses during memory consolidation (Gassmann and Bettler, 2012;Vigot et al, 2006). Saturated postsynaptic responses would likely impair LTP in CA3-CA1 synapses similar to what is observed in GABA B(1a) KO mice (Vigot et al, 2006), moving synaptic plasticity outside of a dynamic range that would support LTP (Gassmann and Bettler, 2012;Vigot et al, 2006). This effect could contribute to a lack of context specificity during consolidation.…”
Section: Gabab(1a) Receptors and Fear Generalizationmentioning
confidence: 96%
“…Here, we find increased generalized contextual fear when GABA B(1a) receptors are blocked within the ventral hippocampus after training. GABA B(1a) receptors are commonly localized to presynaptic terminals of glutamatergic neurons within the hippocampus (Gassmann and Bettler, 2012;Guetg et al, 2009;Vigot et al, 2006). Thus, blocking these receptors within the dorsal or ventral CA1 could result in augmented glutamate release from CA3 or possibly entorhinal inputs, resulting in saturated postsynaptic responses during memory consolidation (Gassmann and Bettler, 2012;Vigot et al, 2006).…”
Section: Gabab(1a) Receptors and Fear Generalizationmentioning
confidence: 99%
See 2 more Smart Citations