Differential effects of general anesthetics on anxiety-like behavior in formalin-induced pain: involvement of ERK activation in the anterior cingulate cortex

Luo, Cong; Zhang, Yanling; Luo, Wei; Zhou, Fiona H.; Xu, Junmei; Dai, Renke

doi:10.1007/s00213-015-4071-2

Cited by 23 publications

(16 citation statements)

References 45 publications

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“…Moreover, previous anesthesia with this barbiturate seems not to interfere with the detection of the anxiolytic-like effect of diazepam in the EPM. Corroborating our results, pentobarbital, another barbiturate, also did not produce any change in rat's behavior in the EPM (Luo et al 2015). On the other hand, Torres et al (1996) showed an acute anxiolytic-like effect of a subanesthetic dose of thiopental in rats tested in the one-way-avoidance test.…”

Section: Thiopental Effectssupporting

confidence: 83%

“…We performed the behavioral tests on naive animals, which means that the animals were not exposed to surgical trauma. There are some evidences suggesting that surgical trauma impacts animal's behavior (Li et al 2010;Luo et al 2015;Wang et al 2017).…”

Section: Implications and Limitations Of The Studymentioning

confidence: 99%

“…Moreover, at least the effects of the anesthetic sevoflurane on anxiety might be affected by pain noxious stimulus (Luo et al 2015). Our choice to evaluate the effects of the anesthetics in naïve animals was based on a strict control of anesthetic dose, given that during surgery, eventually, is necessary to reapply the anesthetic to ensure surgical anesthesia.…”

Section: Implications and Limitations Of The Studymentioning

confidence: 99%

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Refinement of anesthetic choice in procedures preceding psychopharmacological studies

Gaigher

Siqueira

et al. 2018

Preprint

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RationalePrevious studies indicated that some general anesthetics induce long-term antidepressant and/or anxiolytic-like effects. This raises the concern about the use of anesthesia in surgeries that precede psycopharmacological tests, since it may be a potential bias on results depending on the experimental design used.ObjectivesTo evaluate whether commonly used general anesthetics in surgeries preceding psychopharmacological tests would affect rat behavior in tests predictive of antidepressant or anxiolytic-like effects. We also evaluated whether prior anesthesia would interfere in the detection of the antidepressant-like effect of imipramine or the anxiolytic-like effect of diazepam.MethodsWe tested if a single exposure to subanesthetic or anesthetic doses of 2,2,2-tribromoethanol, chloral hydrate, thiopental or isoflurane would change rat’s behavior in the forced swimming test (FST) or in the elevated plus-maze (EPM) test, at 2 hours or 7 days after administration.ResultsPrevious anesthesia with the aforementioned anesthetics did not change rat behavior in FST per se nor it changed the antidepressant-like effect induced by imipramine treatment. Rats previously anesthetized with tribromoethanol or chloral hydrate exhibited, respectively, anxiogenic-like or anxiolytic-like behavior in the EPM. Prior anesthesia with thiopental or isoflurane did not produce anyper seeffect in rat behavior in the EPM nor disturbed the anxiolytic-like effect of diazepam.ConclusionOur results suggest that, in our experimental conditions, tribromoethanol and chloral hydrate are improper anesthetics for surgeries that precede behavioral tests related to anxiety. Isoflurane or thiopental may be suitable for anesthesia before evaluation in animal models predictive of antidepressant or anxiolytic-like effect.

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Section: Thiopental Effectssupporting

confidence: 83%

Section: Implications and Limitations Of The Studymentioning

confidence: 99%

Section: Implications and Limitations Of The Studymentioning

confidence: 99%

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Refinement of anesthetic choice in procedures preceding psychopharmacological studies

Gaigher

Siqueira

et al. 2018

Preprint

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“…The anxiolytic and sedative actions of some drugs occur through chloride ion channel opening [12,42,43]. Pentobarbital, an anesthetic drug with actions at GABA A receptors, produces ataxia and motor incoordination [41], but its potency as an anxiolytic agent is equivocal [44,45]. A similar profile was found for oleic acid, which increases the affinity of agonists for the benzodiazepine binding site on GABA A receptors [10].…”

Section: Discussionmentioning

confidence: 91%

Oleic Acid Produces Motor Incoordination and Hypoactivity in Infant Wistar Rats Through GABA<sub>A</sub> Receptors

Guillén-Ruiz¹

2016

AJPN

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A mixture of eight fatty acids (linoleic, oleic, palmitic, stearic, myristic, elaidic, lauric, and palmitoleic acids) at similar concentrations that have been identified in human amniotic fluid exerts anxiolytic-like effects similar to diazepam in adult Wistar rats through actions at γ-aminobutyric acid-A (GABA A) receptors, but unknown is whether any of these fatty acids exerts a predominant action over the others in infant rats. Of these fatty acids, some actions of oleic acid have already been identified, and it is one of the most abundant in amniotic fluid. Therefore, the aim of this study was to explore the effect of oleic acid on anxiety-like behavior and motoric activity in infant rats. To explore sedative actions, 28-day-old Wistar rats received 80-320 µg oleic acid or a sedative dose of diazepam (5 mg/kg). In a dose-response study, other groups of rats were injected with 10-80 µg oleic acid or 1 mg/kg diazepam. In an interaction study, rats that received oleic acid were pretreated with the GABA A receptor antagonists picrotoxin or flumazenil to explore the participation of this receptor in the effects of oleic acid on behavior in the elevated plus maze, rotarod test, and open field test. Oleic acid produced sedative effects but did not exert any anxiolytic-like actions. Hypoactivity and motor incoordination that were induced by oleic acid were blocked by flumazenil and picrotoxin. In conclusion, oleic acid reduced locomotor activity and motor incoordination through actions at the GABA A receptor.

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“…Moreover, Haseneder et al (28) showed that sevoflurane elevates the expression of the NMDA receptor type 1 and 2B subunits in the hippocampus leading to less anxious behaviour. Another study conducted by Luo et al (29) suggested that sevoflurane inhibits pain-related anxiety, along with ERK activation. However, the relationship between dexamethasone and anxiety is complicated.…”

Section: Discussionmentioning

confidence: 97%

Short-Term and Long-Term Effects of Dexamethasone on Cognitive Dysfunction Induced by Sevoflurane in Adult Rats

Karaman

Doğru

et al. 2017

Turk J Anaesth Reanim

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Objective: Postoperative cognitive dysfunction (POCD) is common after anaesthesia in elderly patients. However, it may appear in patients of all ages. The main pathogenesis of cognitive dysfunction remains unclear, although there is some evidence that brain inflammation may alter cognitive abilities. In the present study, we aim to evaluate short-term and long-term effects of dexamethasone on cognitive dysfunction induced by sevoflurane anaesthesia in adult rats.Methods: Seven-month-old 30 male Wistar albino rats were randomised into three groups: sevoflurane group (exposure to sevoflurane), sevoflurane + dexamethasone group (exposure to sevoflurane and dexamethasone injection), and control group (exposure to 100% oxygen). Spatial learning and short-term (7 days after exposure) and long-term (30 days after exposure) memory were evaluated using Morris water maze test.Results: Sevoflurane induced significant deficit in spatial learning and short-term and long-term memory in adult rats. Dexamethasone-treated animals exposed to sevoflurane had equivalent performance as control animals in training and probe trials. Conclusion:Sevoflurane may impair spatial learning and short-term and long-term memories in adult rats. The co-administration of dexamethasone and sevoflurane may ameliorate short-term and long-term cognitive dysfunctions induced by sevoflurane in adult rats. Keywords: Sevoflurane, dexamethasone, cognitive disordersAmaç: Postoperatif kognitif disfonksiyon (POKD) yaşlı hastalarda anestezi sonrası sık olmaktadır. Ancak POKD tüm yaşlarda da görü-lebilmektedir. Kognitif disfonksiyonun temel patogenezi tam olarak bilinmemekle birlikte beyin inflamasyonunun bilişsel yetenekleri değiştirebildiğine dair bazı kanıtlar bulunmaktadır. Bu çalışmada, erişkin farelerde sevofluran anestezisi ile oluşturulmuş kognitif disfonksiyon üzerine deksametazonun erken ve geç dönem etkilerini araştırmayı amaçladık.Yöntemler: Yedi aylık 30 erkek wistar albino rat üç gruba ayrıldı; grup sevofluran (sevofluran anestezisine maruziyet), grup sevofluran+deksametazon (sevofluran anestezisiyle birlikte deksametazon enjeksiyonuna maruziyet) ve grup kontrol (%100 oksijene maruziyet). Uzaysal öğrenme, erken (maruziyetten 7 gün sonra) ve geç (maruziyetten 30 gün sonra) dönem hafıza Morris su labirenti testi ile değerlendirildi. Bulgular: Sevofluran anestezisi erişkin ratlarda uzaysal öğrenme, erken ve geç dönem hafıza üzerinde anlamlı derecede olumsuz etki oluşturdu. Deksametazon ile tedavi edilmiş ratlar ise eğitim ve araş-tırma testlerinde kontrol grubuna benzer bir performans gösterdi.Sonuç: Sevofluran erişkin ratlarda uzaysal öğrenmeyi, erken ve geç dönem hafızayı olumsuz etkileyebilir. Sevofluran anestezisi ile birlikte deksametazon uygulanması erişkin ratlarda sevofluran ile oluş-turulmuş erken ve geç dönem kognitif disfonksiyonu iyileştirebilir.Anahtar sözcükler: Sevofluran, deksametazon, biliş bozuklukları Abstract / Öz

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Differential effects of general anesthetics on anxiety-like behavior in formalin-induced pain: involvement of ERK activation in the anterior cingulate cortex

Cited by 23 publications

References 45 publications

Refinement of anesthetic choice in procedures preceding psychopharmacological studies

Refinement of anesthetic choice in procedures preceding psychopharmacological studies

Oleic Acid Produces Motor Incoordination and Hypoactivity in Infant Wistar Rats Through GABA<sub>A</sub> Receptors

Short-Term and Long-Term Effects of Dexamethasone on Cognitive Dysfunction Induced by Sevoflurane in Adult Rats

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Differential effects of general anesthetics on anxiety-like behavior in formalin-induced pain: involvement of ERK activation in the anterior cingulate cortex

Cited by 23 publications

References 45 publications

Refinement of anesthetic choice in procedures preceding psychopharmacological studies

Refinement of anesthetic choice in procedures preceding psychopharmacological studies

Oleic Acid Produces Motor Incoordination and Hypoactivity in Infant Wistar Rats Through GABA&lt;sub&gt;A&lt;/sub&gt; Receptors

Short-Term and Long-Term Effects of Dexamethasone on Cognitive Dysfunction Induced by Sevoflurane in Adult Rats

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Oleic Acid Produces Motor Incoordination and Hypoactivity in Infant Wistar Rats Through GABA<sub>A</sub> Receptors