Differential effects of hippocampal lesions on maze and passive avoidance learning in rats

Kveim, O; Setekleiv, J.; Kaada, B

doi:10.1016/0014-4886(64)90043-3

Cited by 51 publications

(15 citation statements)

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“…The present data and those of Neocortical a previous study (Niki, 1965) suggest that hippocampal ablation would reduce the response inhibition, and therefore would produce the tendency for the animal to perseverate. There is some possibility that the suggested perseverative tendency (one of the manifestations of inhibitory deficits) in the present experiments could explain some of the previous reports on learning deficits following the hippocampal ablation (Thomas & Otis, 1958;Orbach et al, 1960;Stepien et al, 1960;Kaada et al, 1961;Niki, 1962Niki, , 1965Kimble, 1963;Kveim et al, 1964).…”

Section: Discussionmentioning

confidence: 52%

Response Perseveration Following the Hippocampal Ablation in the Rat

Niki

1966

Jpn. Psychol. Res

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Section: Discussionmentioning

confidence: 52%

Response Perseveration Following the Hippocampal Ablation in the Rat

Niki

1966

Jpn. Psychol. Res

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“…This is exactly the pattern of the results for AA in animals. 1 Hippocampal animals are deficient in learning complex mazes (D. Kimble, 1963;Kveim, Setekliev, & Kaada, 1964;Leaton, 1969). Chunking is presumed to occur in complex maze learning to form a cognitive map composed of what-leads-to-what (propositional) expectancy nodes.…”

Section: A a Is A Chunking Deficitmentioning

confidence: 99%

Chunking and consolidation: A theoretical synthesis of semantic networks, configuring in conditioning, S-R versus cognitive learning, normal forgetting, the amnesic syndrome, and the hippocampal arousal system.

Wickelgren¹

1979

Psychological Review

512

207

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Horizontal versus vertical associative memory concepts are denned. Vertical associative memory involves chunking: the specification of new (previously free) nodes to represent combinations of old (bound) nodes. Chunking is the basis of semantic memory, configuring in conditioning, and cognitive (as opposed to stimulus-response) learning. The cortex has the capacity for chunking, but the hippocampal (limbic) arousal system plays a critical role in this chunking process by differentially priming (partially activating) free, as opposed to bound, neurons. Binding a neuron produces negatively accelerated repression of its connections to the hippocampal arousal system, consolidating the memory by protecting the newly bound neuron from diffuse hippocampal input and thus retarding forgetting. Disruption of the hippocampal arousal system produces the amnesic syndrome of an inability to do new chunking (cognitive learning)-anterograde amnesia-and an inability to retrieve recently specified chunks-retrograde amnesia.With a time period of development spanning over two thousand years of human history, the doctrine of the association of ideas is to this day the dominant theory of the mind. I imagine there were always protesters who claimed that the mind was too complex to be encompassed by such associationism. However, until recently, there was no comparably elegant and general alternative theory. Now there is such a theory, though as is so often the case, the new theory is more of an extension than a repudiation of classical associationism.The basic idea derives from the concept of chunking. Chunking was originally formulated by G. Miller (1956), but subsequently chunking has been implicated in a wide variety of

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“…It appears that large posterior dorsal lesions (Teitelbaum & Milner, 1963) are more effective than anterior dorsal hippocampaI lesions (Kaada et al, 1962;Kveim et al, 1964) in producing a deficit in passive avoidance. In addition to lesion locus, the nature of the passive avoidance task used (Snyder & Isaacson, 1965) and the amount of pretraining (Isaacson et al, 1966;Kimble et al, 1966) appear to be important variables in the degree of passive avoidance impa~r-ment that is found after hippocampectomy.…”

Section: Hippocampusmentioning

confidence: 99%

Amygdaloid lesions and behavioral inhibition in the rat.

Pellegrino¹

1968

Journal of Comparative and Physiological Psychology

135

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Rats with bilateral lesions of the basolateral region of the amygdala were impaired in passive avoidance, DRL performance, and spatial alternations without cues, but not in visually cued spatial alternations or go-no-go visual discriminations and reversals. Except for a small deficit in passive avoidance, rats with lesions in the corticomedial region of the amygdala were not impaired in these tasks. Deficits produced by basolateral lesions can not readily be attributed to increased motivation for food or water. Results suggest that rats with basolateral amygdaloid lesions are unable to inhibit established responses when they must depend on information provided by internal cues.1 This report is based on a dissertation submitted to McGill University in partial fulfillment of the requirements for the PhD degree. The author wishes to thank his thesis adviser, R. B.

show abstract

Differential effects of hippocampal lesions on maze and passive avoidance learning in rats

Cited by 51 publications

References 8 publications

Response Perseveration Following the Hippocampal Ablation in the Rat

Response Perseveration Following the Hippocampal Ablation in the Rat

Chunking and consolidation: A theoretical synthesis of semantic networks, configuring in conditioning, S-R versus cognitive learning, normal forgetting, the amnesic syndrome, and the hippocampal arousal system.

Amygdaloid lesions and behavioral inhibition in the rat.

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