Differential effects of polyphenols and alcohol of red wine on the expression of adhesion molecules and inflammatory cytokines related to atherosclerosis: a randomized clinical trial

Chiva‐Blanch, Gemma; Urpí-Sardà, Mireia; Llorach, Rafaël; Rotches-Ribalta, María; Guillén, Marisa; Casas, Rosa; Arranz, Sara; Valderas-Martínez, Palmira; Portolés, Olga; Corella, Dolores; Tinahones, Francisco J.; Lamuela‐Raventós, Rosa M.; Andrés‐Lacueva, Cristina; Estruch, Ramón

doi:10.3945/ajcn.111.022889

Cited by 158 publications

(102 citation statements)

References 47 publications

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“…Small randomised controlled clinical studies, however, as well as an observational study of 483 subjects followed for four years, suggest that moderate alcohol consumption reduces C-reactive protein, and the pro-inflammatory cytokines interleukin-6 and tissue necrosis factor-␣ [158,165,166]. Supporting the results of initial in vitro studies [167], a down-regulation and hence reduction in the plasma concentration of the soluble inflammatory mediators CD40 ligand, IL-16, monocyte chemotactic protein (MCP)-1, vascular cell adhesion molecule (VCAM)-1 and E-selectin has also been recently observed in high-CVD-risk subjects following 30 g of alcohol/day [168].…”

Section: Inflammatory Effectssupporting

confidence: 54%

The relationships between alcohol, wine and cardiovascular diseases –A review

Stockley¹

2016

NUA

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Abstract.The relationship between alcohol consumption and the risk of cardiovascular disease has now been studied for over fifty years, and confirmed in multiples case-controlled and cohort studies, and subsequent meta-analyses of these studies. Sound experimental and clinical studies of plausible biological mechanisms support that there is a causal relationship between alcoholic beverages and cardiovascular disease. While beer, wine and spirits all contain alcohol, they are not necessarily equal in their effects on cardiovascular health, such as the incidence and mortality of coronary heart disease, stroke and all-cause mortality. Hence this review evaluates the available evidence, and details the biological mechanisms and attributes a percentage reduction in harm where possible.

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Section: Inflammatory Effectssupporting

confidence: 54%

The relationships between alcohol, wine and cardiovascular diseases –A review

Stockley¹

2016

NUA

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“…Furthermore, red wine, which contains phenolic compounds, has been shown to affect the composition of human gut microbiota [37]. Phenolic compounds of red wine down-regulated serum concentrations of several cytokines and inflammatory markers, whereas others were increased [38]. Thus, the effect of ethanol in red wine may be counterbalanced by phenolic compounds.…”

Section: Patients With Irritable Bowel Syndromementioning

confidence: 99%

Diarrhoea is not the only symptom that needs to be treated in patients with microscopic colitis

Roth¹,

Bengtsson²,

Ohlsson³

2013

European Journal of Internal Medicine

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Diarrhoea is not the only symptom that needs to be treated in patients with microscopic colitis. Link to publication Citation for published version (APA): Roth, B., Bengtsson, M., & Ohlsson, B. (2013). Diarrhoea is not the only symptom that needs to be treated in patients with microscopic colitis. European Journal of Internal Medicine, 24(6), 573-578. DOI: 10.1016573-578. DOI: 10. /j.ejim.2013 General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal

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“…There is limited and conflicting evidence from interventional studies, typically with sample sizes of <100 participants and over relatively short periods of time, of the association between alcohol consumption and inflammation 7, 27, 28, 29. In terms of observational studies, some investigators have found that moderate alcohol consumption is associated with lower levels of CRP 30, 31, 32 and IL‐6 32, 33 compared to no alcohol and heavy alcohol intake, whereas others have observed no association 33, 34.…”

Section: Introductionmentioning

confidence: 99%

Ten‐year alcohol consumption typologies and trajectories of C‐reactive protein, interleukin‐6 and interleukin‐1 receptor antagonist over the following 12 years: a prospective cohort study

et al. 2016

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BackgroundModerate alcohol consumption is thought to confer cardiometabolic protective effects. Inflammatory pathways are hypothesized to partly underlie this association.ObjectivesThe aim of this study was to examine the association between typologies of alcohol consumption and markers of inflammation, and their rate of change over time.MethodsData were collected from 8209 participants [69% men; mean age, 50 years (SD 6.1)] of the British Whitehall II study. Alcohol consumption typologies were defined using up to three measures during an approximately 10‐year period spanning from 1985 to 1994 as (i) stable nondrinkers, (ii) stable moderate drinkers (referent), (iii) stable heavy drinkers, (iv) nonstable drinkers and (v) former drinkers. C‐reactive protein (CRP), interleukin (IL)‐6 and IL‐1 receptor antagonist (IL‐1 RA) were measured up to three times in the following 12 years.ResultsStable moderate drinkers had lower levels of CRP than stable nondrinkers, stable heavy drinkers, former drinkers and nonstable drinkers, but there were no differences in the rate of change in CRP over time between groups. Stable nondrinkers had higher levels of IL‐6 as did stable heavy drinkers; rates of change in IL‐6 over time were also increased in the latter group. Stable nondrinkers also had higher levels of IL‐1 RA. These associations were robust to adjustment for confounding factors.ConclusionOur novel investigation of 10‐year drinking typologies shows that stable moderate alcohol consumption is associated with a long‐term inflammatory marker profile that is consistent with conferring a reduced risk of developing coronary heart disease.

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Differential effects of polyphenols and alcohol of red wine on the expression of adhesion molecules and inflammatory cytokines related to atherosclerosis: a randomized clinical trial

Cited by 158 publications

References 47 publications

The relationships between alcohol, wine and cardiovascular diseases –A review

The relationships between alcohol, wine and cardiovascular diseases –A review

Diarrhoea is not the only symptom that needs to be treated in patients with microscopic colitis

Ten‐year alcohol consumption typologies and trajectories of C‐reactive protein, interleukin‐6 and interleukin‐1 receptor antagonist over the following 12 years: a prospective cohort study

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