Differential electrolytic potentiometric determination of some thiol compounds in their dosage forms

Al-Ghannam, Sheikha M.

doi:10.1016/j.farmac.2003.12.004

Cited by 9 publications

(5 citation statements)

References 15 publications

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“…From various titration studies reported 38–40, thiols (including captopril) are known to form a 1 : 1 complex with silver ions. As the potential sweep starts from −0.3 V vs. MSE in Figure 1A and Figure 4, the silver on the surface of GSPE is oxidised into silver ions.…”

Section: Resultsmentioning

confidence: 99%

“…As the potential sweep starts from −0.3 V vs. MSE in Figure 1A and Figure 4, the silver on the surface of GSPE is oxidised into silver ions. (Equation 1) The argentite ions can interact with captopril to form a silver thiol complex as stated in Equation 1 38–40. Then, the complex can be electrochemically oxidised to form the dimer, hence releasing free silver ions to further react with RSH, accounting for the signal observed at ca.…”

Section: Resultsmentioning

confidence: 99%

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Voltammetric Detection of Captopril on Graphite Screen Printed Electrodes

et al. 2015

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We report the electrochemical detection of captopril on commercially available screen printed electrodes (GSPE); it exploits the silver residue left behind on a GSPE during its manufacturing process and involves the catalytic formation of the silver thiol complex (Ag++RSH→AgSR+H+) at potentials corresponding to the oxidation of silver. The oxidation of the silver thiol complex was found to vary linearly with the captopril concentration up to 0.8 mM. A sensitivity of 13.34±0.58 μA mM−1 is reported with a limit of detection of 4.27±0.18 μM.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Voltammetric Detection of Captopril on Graphite Screen Printed Electrodes

et al. 2015

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“…Electrochemical techniques such as amperometry 21–23, potentiometry 24–26, stripping voltammetry 27, 28, voltammetric methods 29–32, and square‐wave voltammetry 33 have also been utilized with the same purpose. The mercury electrode is one of the most commonly utilized for the electrochemical determination of CAP, but because it is contaminated by intermediates from the oxidation, presents problems for voltammetric determinations 28, 29, 33.…”

Section: Introductionmentioning

confidence: 99%

Captopril Electrochemical Oxidation on Fluorine‐Doped SnO₂ Electrodes and Their Determination in Pharmaceutical Preparations

et al. 2010

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A novel application of fluorine-doped tin oxide (FTO) electrodes is reported in the present work. To this end, the captopril electrochemical oxidation mechanism on FTO electrodes at various pH and its determination in pharmaceutical preparations was investigated. Captopril oxidation on FTO proceeds at pH between 2.0 and 4.0. The study revealed that interferences for captopril determination in pharmaceutical samples was totally suppressed using these electrode materials. Voltammetric survey showed an anodic peak at about 0.375 V (Ag j AgCl) for captopril oxidation, that takes place through an EC process at pH interval 2.0-4.0. The investigation demonstrated that captopril oxidation occurs through protonated species and these electroactive species interact by adsorption on FTO electrodes, with a large heterogeneous rate constant and a mechanism involving 1H + /1e À in the global reaction. Moreover, a captopril sensor based upon FTO electrodes, with a linear range miliMolar, is proposed. These electrodes are promising candidates for the efficient electrochemical determination of captopril in pharmaceutical preparations.

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“…However, the speciation analysis is normally impaired by this strategy. Sulfur speciation studies including short and long chain compounds have been undertaken by gas and liquid chromatography [1 -4], by spectroscopic methods [5,6] and by electrochemical methods including potentiometry [7,8] and voltammetry [4 -6, 8 -14]. For low-molecular-weight S-compounds, speciation and direct determinations are mainly restricted to voltammetric and gas chromatographic methods.…”

Section: Introductionmentioning

confidence: 99%

Voltammetric Determination of Low‐Molecular‐Weight Sulfur Compounds in Hydrothermal Vent Fluids – Studies with Hydrogen Sulfide, Methanethiol, Ethanethiol and Propanethiol

et al. 2010

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Determination of sulfide compounds in hydrothermal vent fluid samples was performed by DPCSV. The methodology was applied to speciate sulfides via primitive and first-derivative curve interpretation. Hydrogen sulfide, methanethiol, and propanethiol were simultaneously assayed in samples containing no ethanethiol. In the presence of ethanethiol, the organic sulfides were determined without speciation. Sulfides were determined in an acidic electrolyte, and detection limits ranging from 0.1 to 1.1 mmol L À1 were calculated. The method was tested in real hydrothermal vent fluid samples, with recoveries ranging from 86.9% (R -SH) to 115.3% (H 2 S). Interference of the metallic species present in seawater was investigated.

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Differential electrolytic potentiometric determination of some thiol compounds in their dosage forms

Cited by 9 publications

References 15 publications

Voltammetric Detection of Captopril on Graphite Screen Printed Electrodes

Voltammetric Detection of Captopril on Graphite Screen Printed Electrodes

Captopril Electrochemical Oxidation on Fluorine‐Doped SnO₂ Electrodes and Their Determination in Pharmaceutical Preparations

Voltammetric Determination of Low‐Molecular‐Weight Sulfur Compounds in Hydrothermal Vent Fluids – Studies with Hydrogen Sulfide, Methanethiol, Ethanethiol and Propanethiol

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Differential electrolytic potentiometric determination of some thiol compounds in their dosage forms

Cited by 9 publications

References 15 publications

Voltammetric Detection of Captopril on Graphite Screen Printed Electrodes

Voltammetric Detection of Captopril on Graphite Screen Printed Electrodes

Captopril Electrochemical Oxidation on Fluorine‐Doped SnO2 Electrodes and Their Determination in Pharmaceutical Preparations

Voltammetric Determination of Low‐Molecular‐Weight Sulfur Compounds in Hydrothermal Vent Fluids – Studies with Hydrogen Sulfide, Methanethiol, Ethanethiol and Propanethiol

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Captopril Electrochemical Oxidation on Fluorine‐Doped SnO₂ Electrodes and Their Determination in Pharmaceutical Preparations