Voltammetric Detection of Captopril on Graphite Screen Printed Electrodes

Abstract

We report the electrochemical detection of captopril on commercially available screen printed electrodes (GSPE); it exploits the silver residue left behind on a GSPE during its manufacturing process and involves the catalytic formation of the silver thiol complex (Ag++RSH→AgSR+H+) at potentials corresponding to the oxidation of silver. The oxidation of the silver thiol complex was found to vary linearly with the captopril concentration up to 0.8 mM. A sensitivity of 13.34±0.58 μA mM−1 is reported with a limit of detection of 4.27±0.18 μM.

Rutin as an Electrochemical Mediator in the Determination of Captopril using a Graphite Paste Electrode

“…This catalytic effect is attributed to the interaction between captopril and the flavonoid since, in the absence of rutin, the direct oxidation of captopril occurs at +1.37 V vs . SCE (Figure , green line) .…”

“…In the presence of rutin and captopril, the current of the anodic peak at + 0.44 V vs. SCE was observed to increase (Figure 2, blue line). This catalytic effect [41] is attributed to the interaction between captopril and the flavonoid since, in the absence of rutin, the direct oxidation of captopril occurs at + 1.37 V vs. SCE (Figure 2, green line) [16,17].…”

“…Conventional techniques, including chromatography , fluorimetry , chemiluminescence and spectroscopy , are available for monitoring the levels of captopril, but they all require a specialized clinical laboratory and analysis can be both time consuming and expensive. In contrast, electrochemical methods typically offer a number of advantages that include simplicity, high sensitivity, rapid detection time and low cost . However, the electrochemical detection of thiols at glassy carbon electrodes is challenging since direct oxidation of the analyte occurs only at high positive potential .…”

Voltammetric Detection of Captopril in a Commercial Drug Using a Gold‐Copper Metal‐organic Framework Nanocomposite Modified Electrode

“…On the other hand, methods involving electrochemical sensors are generally simple, rapid and low cost. In this context, a number of electrochemical methods have been described for the quantification of CAP involving, for example, graphite screen‐printed electrodes [33], cupric oxide‐ modified indium‐tin‐oxide electrodes [34], GCEs modified with graphene copper hexacyanoferrate nanoparticles [35], and multi‐wall carbon nanotube paste electrodes with a mediator [36] or modified with ferrocene‐based polyamide [37] or cupric oxide nanoparticles [38].…”

Fast and Simple Electrochemical Analysis Kit for Quality Control of Narrow Therapeutic Index Drugs

“…The coupling of a portable instrument and, consequently, miniaturization of the system is possible. The use of SPE has become an extremely useful tool for providing fast, sensitive, selective and low‐cost analyses in different electroanalytical techniques for the determination of many compounds . Recently, the use of SPE coupled to a batch injection analysis (BIA) system was proposed.…”