Differential expression of STAT3 gene and its regulatory long non-coding RNAs, namely lnc-DC and THRIL, in two eastern Iranian ethnicities with multiple sclerosis

Kakhki, Majid Pahlevan; Rakhshi, Nahid; Aleagha, Mohammad Sajad Emami; Abdari, Mahla; Alikhah, Asieh; Safarian, Ghazal; Behmanesh, Mehrdad; Nikravesh, Abbas

doi:10.1007/s10072-019-04092-y

Cited by 6 publications

(8 citation statements)

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“…We 78 , its upregulation was reported by two other studies in serum and PBMCs of MS patients 56,57 .…”

Section: Discussionsupporting

confidence: 71%

“…One study revealed decreased level of MALAT1 in brain tissue of MS patients and CNS of EAE mice 77 . Regarding Lnc-DC, While Pahlevan Kakhki et al, 2019 did not observe any expression change for this lncRNA in two Iranian ethnicities afflicted by MS 78 , its upregulation was reported by two other studies in serum and PBMCs of MS patients 56,57 .…”

Section: Discussionmentioning

confidence: 87%

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Expression of remyelination-modulating genes in astrocytes are controlled by MALAT1 and Lnc-DC long non-coding RNAs

Askari

Khani-Habibabadi

Behmanesh

2021

Preprint

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Astrocyte-secreted factors play multifunctional roles in central nervous system (CNS) in health and disease. Here, we examined the regulatory machinery of long non-coding RNAs (lncRNAs) on gene expression of several factors of great importance in remyelination - CNTF, NT-3, FGF2 and PDGF-C - in human astrocytoma cell line via in silico and experimental studies. To know any expression correlations among these genes as well as their changes in inflammatory conditions, their expression was measured under H2O2 induction. Using available databases, a computational screening was performed to collect lncRNAs having the potentiality of regulating expression of the target genes. MALAT1 and Lnc-DC were selected as high potential expression regulators of four genes of the study among 40 lncRNAs that were evaluated bioinformatically. Downregulation of remyelination-modulating genes of interest under DNAzyme-induced suppression of MALAT1 or Lnc-DC verified the regulatory role of these lncRNAs. More detailed information on expression regulatory machinery of lncRNAs and remyelination-modulating genes in inflammatory conditions could pave the way for understanding the reasons of their inefficiency in demyelinating diseases such as Multiple Sclerosis (MS).

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“…We 78 , its upregulation was reported by two other studies in serum and PBMCs of MS patients 56,57 .…”

Section: Discussionsupporting

confidence: 71%

Section: Discussionmentioning

confidence: 87%

Expression of remyelination-modulating genes in astrocytes are controlled by MALAT1 and Lnc-DC long non-coding RNAs

Askari

Khani-Habibabadi

Behmanesh

2021

Preprint

Self Cite

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“…THRIL regulates TNF-α expression via its interaction with heterogeneous nuclear ribonucleoprotein L (hnRNPL) and persuades a transcriptional-activating complex, finally connecting to the TNF-α promoter ( 91 ). THRIL can suppress STAT3 ( 51 ).…”

Section: Resultsmentioning

confidence: 99%

“…Lnc-DC positively regulates STAT3 resulting in the differentiation of monocyte cell to dendritic cells ( 92 ). This lncRNA is involved in the pathogenesis of sepsis ( 93 ), coronary artery disease ( 94 ), pre-eclampsia ( 95 ), MS ( 51 ), and systemic lupus erythematosus (SLE) ( 96 ). Xie et al.…”

Section: Resultsmentioning

confidence: 99%

“…THRIL regulates TNF-a expression via its interaction with heterogeneous nuclear ribonucleoprotein L (hnRNPL) and persuades a transcriptional-activating complex, finally connecting to the TNF-a promoter (91). THRIL can suppress STAT3 (51). Lnc-DC (also known as Wfdc21) is a non-coding RNA gene on the minus strand of chromosome 17q23.1, which was firstly identified by Wang et al to have an important role in the differentiation of dendritic cells and the regulation of the immune response (92,93).…”

Section: Tob1-as1mentioning

confidence: 99%

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Long Non-Coding RNAs, Novel Offenders or Guardians in Multiple Sclerosis: A Scoping Review

et al. 2021

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Multiple sclerosis (MS), a chronic inflammatory demyelinating disease of the central nervous system, is one of the most common neurodegenerative diseases worldwide. MS results in serious neurological dysfunctions and disability. Disturbances in coding and non-coding genes are key components leading to neurodegeneration along with environmental factors. Long non-coding RNAs (lncRNAs) are long molecules in cells that take part in the regulation of gene expression. Several studies have confirmed the role of lncRNAs in neurodegenerative diseases such as MS. In the current study, we performed a systematic analysis of the role of lncRNAs in this disorder. In total, 53 studies were recognized as eligible for this systematic review. Of the listed lncRNAs, 52 lncRNAs were upregulated, 37 lncRNAs were downregulated, and 11 lncRNAs had no significant expression difference in MS patients compared with controls. We also summarized some of the mechanisms of lncRNA functions in MS. The emerging role of lncRNAs in neurodegenerative diseases suggests that their dysregulation could trigger neuronal death via still unexplored RNA-based regulatory mechanisms. Evaluation of their diagnostic significance and therapeutic potential could help in the design of novel treatments for MS.

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Expression Analysis of Long Non-coding RNA Lnc-DC in HLA-DRB1*15:01-Negative Patients with Multiple Sclerosis: A Probable Cause for Gender Differences in Multiple Sclerosis Susceptibility?

et al. 2020

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Differential expression of STAT3 gene and its regulatory long non-coding RNAs, namely lnc-DC and THRIL, in two eastern Iranian ethnicities with multiple sclerosis

Cited by 6 publications

References 38 publications

Expression of remyelination-modulating genes in astrocytes are controlled by MALAT1 and Lnc-DC long non-coding RNAs

Expression of remyelination-modulating genes in astrocytes are controlled by MALAT1 and Lnc-DC long non-coding RNAs

Long Non-Coding RNAs, Novel Offenders or Guardians in Multiple Sclerosis: A Scoping Review

Expression Analysis of Long Non-coding RNA Lnc-DC in HLA-DRB1*15:01-Negative Patients with Multiple Sclerosis: A Probable Cause for Gender Differences in Multiple Sclerosis Susceptibility?

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