Differential expression profiles of the Hedgehog signaling pathway between microsatellite-stable and microsatellite-unstable colorectal cancers

Cui, Long

doi:10.3892/mmr.2011.529

Cited by 4 publications

(6 citation statements)

References 20 publications

(22 reference statements)

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“…In the present study, no correlation was found between Shh immunoexpression and most clinicopathological features. In one study, there were similar findings [ 24 ]. In other studies, there were some different results.…”

Section: Discussionsupporting

confidence: 61%

“…Also they reported that well differentiated tumours shown more intense Shh expression than high grade carcinomas [ 1 ]. Others found that there was no association between Shh and tumour differentiation [ 2 24 ]. During embryogenesis, the Hh signalling pathway is essential for organ patterning, cell differentiation and cell proliferation [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

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The significance of sonic hedgehog immunohistochemical expression in colorectal carcinoma

Ghamdi

Gomaa

Abulaban

et al. 2015

J Microsc Ultrastruct

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Colorectal carcinoma is a significant source of major morbidity and mortality. Sonic hedgehog (Shh) is expressed in normal gastrointestinal tract mucosa and in many malignancies. The purpose of the present study is to investigate the relationship between Shh immunoexpression in CRC and clinicopathological characteristics. Paraffin blocks of 155 primary CRCs and 37 nodal metastases were retrieved and tissue microarrays were constructed. Immunohistochemistry was performed using anti-Shh antibody. Immunostaining was scored and results were analysed in relation to the clinicopathological parameters. Shh was overexpressed in primary CRC (p = 0.02) and in nodal metastasis (p = 0.004). There was no difference between Shh immunoexpression in primary CRC and in nodal metastasis (p = 0.941). High Shh immunoexpression was associated with well differentiated tumours (p = 0.004). However, there was no association with other clinicopathological parameters. Shh overexpression was not associated disease free survival (log-rank = 0.079, p = 0.778). Shh is overexpressed in well differentiated CRC. However, Shh is not associated with other clinicopathological and prognostic factors. Loss of Shh may be associated with proliferation and loss of differentiation in CRC. Further molecular studies are required to address the potential importance of Shh signalling in CRC and to test Shh inhibitors and activators as potential therapeutic targets in CRC.

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Section: Discussionsupporting

confidence: 61%

Section: Discussionmentioning

confidence: 99%

The significance of sonic hedgehog immunohistochemical expression in colorectal carcinoma

Ghamdi

Gomaa

Abulaban

et al. 2015

J Microsc Ultrastruct

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“…In several studies, Gli1 expression level in CRC tissues varies from 30% to 79%, with staining being either cytoplasmic or nuclear (46)(47)(48)(49)(50)(51). In our study, 45,87% of the tumors stained positive for Gli-1.…”

Section: Discussionsupporting

confidence: 56%

“…Patched-1 overexpression has been correlated with moderately differentiated tumors (47) and nodal status (50), as well as, with worse DFS and OS in patients with earlystage cancer that underwent curative treatment (47,50). Contradictory results were reported in a small study of 19 patients, where low levels of Patched-1 mRNA expression were associated with a higher risk of metastasis (54).…”

Section: Discussionmentioning

confidence: 98%

Association of Notch and Hedgehog Pathway Activation With Prognosis in Early-stage Colorectal Cancer

Rallis

Κoletsa

Saridaki³

et al. 2019

Anticancer Res

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Background/Aim: Early-stage colorectal cancer (CRC) carries a wide range of survival probabilities. Novel biomarkers in this setting are eagerly awaited. Cancer stem cells (CSCs) are considered one of the reasons for treatment failure. This study sought to determine whether activation of pathways governing the function of CSC's could correlate with treatment outcomes. Materials and Methods: Tumor specimens from 325 patients were analyzed with immunohistochemistry (IHC) for Hedgehog and Notch pathway activation and results were correlated with prognosis. Results: Positive Notch3 protein expression was an unfavorable prognostic factor for disease-free survival (DFS) and overall survival (OS) (HR=2.43, p=0.024 and HR=2.56, p=0.028, respectively). Activation of the Shh pathway showed univariately longer DFS (HR=0.49, p=0.032). Possible crosstalk between the two pathways was indicated. No further associations between pathway activation and outcome were evident. Conclusion: Apart from Notch 3, activation of the pathways, as indicated by IHC expression of their components, did not result in differences in terms of DFS or OS.

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“…The study by Stefanius et al revealed no correlation between Hh and colorectal serrated adenocarcinomas 59. Hu et al also reported that Hh signals were more frequently expressed in the microsatellite instable group, compared with the microsatellite stable group in CRC 60. All those studies described that the activation of the Hh signaling pathway is restricted in several types of CRC, but not in other types of cancer.…”

Section: Hh Signaling Pathway In Crcmentioning

confidence: 98%

Hedgehog signaling pathway in colorectal cancer: function, mechanism, and therapy

Zhu

Liu

et al. 2017

OTT

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Colorectal cancer (CRC) is one of the most common gastrointestinal cancers worldwide. It is a complicated and often fatal cancer, and is related to a high disease-related mortality. Around 90% of mortalities are caused by the metastasis of CRC. Current treatment statistics shows a less than 5% 5-year survival for patients with metastatic disease. The development and metastasis of CRC involve multiple factors and mechanisms. The Hedgehog (Hh) signaling plays an important role in embryogenesis and somatic development. Abnormal activation of the Hh pathway has been proven to be related to several types of human cancers. The role of Hh signaling in CRC, however, remains controversial. In this review, we will go through previous literature on the Hh signaling and its functions in the formation, proliferation, and metastasis of CRC. We will also discuss the potential of targeting Hh signaling pathway in the treatment, prognosis, and prevention of CRC.

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Differential expression profiles of the Hedgehog signaling pathway between microsatellite-stable and microsatellite-unstable colorectal cancers

Cited by 4 publications

References 20 publications

The significance of sonic hedgehog immunohistochemical expression in colorectal carcinoma

The significance of sonic hedgehog immunohistochemical expression in colorectal carcinoma

Association of Notch and Hedgehog Pathway Activation With Prognosis in Early-stage Colorectal Cancer

Hedgehog signaling pathway in colorectal cancer: function, mechanism, and therapy

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