Differential regulation of activity-dependent neuroprotective protein in rat astrocytes by VIP and PACAP

VPAC2Receptors Mediate Vasoactive Intestinal Peptide-Induced Neuroprotection against Neonatal Excitotoxic Brain Lesions in Mice

“…Our results are in accordance with an in vitro study suggesting VPAC 2 involvement in neuroprotection (Zusev and Gozes, 2004). They studied activity-dependent neuroprotective protein (ADNF) expression in astrocytes cell cultures.…”

“…Indeed, 1) ADNF was previously shown to be a VIP-responsive gene in astrocytes derived from the cerebral cortex of newborn rats (Bassan et al, 1999); and 2) VIP neuroprotective properties are mediated through interaction with glial cells (Brenneman et al, 1987;Gozes et al, 1991;Gressens et al, 1998). They showed that VIP induced changes in ADNF expression in astrocyte cell cultures via the VPAC 2 receptor (Zusev and Gozes, 2004).…”

Pituitary Adenylate Cyclase-Activating Polypeptide and Its Receptors: 20 Years after the Discovery

“…In particular, PACAP activates the expression and release of ciliary neurotrophic factor, activity-dependent neuroprotective protein, IL-6, glial cell linederived neurotrophic factor, MIP, and regulated on activation normal T cell expressed and secreted (Gottschall et al, 1994;Nagao et al, 1995;Brenneman et al, 2002Brenneman et al, , 2003Delgado et al, 2002a;Kimura et al, 2003;Zusev and Gozes, 2004;Dejda et al, 2005;Nakamachi et al, 2006;Nakatani et al, 2006). PACAP may also affect the expression of other neurotrophic factors, such as the protease nexin-1 or neurotrophin-3, known to be regulated by VIP.…”

VIP–PACAP 2010: My Own Perspective on Modulation of Cognitive and Emotional Behavior

“…Turning back to VIP, the VIP-related peptide, PACAP (Arimura 1992) also regulates ADNP (Nakamachi et al 2006;Nakamachi et al 2008;Zusev and Gozes 2004). At least three receptors for PACAP and VIP have been identified.…”

“…The PACAP-specific receptor, PAC1 receptor, exhibits a higher affinity for PACAP than VIP, whereas VIP receptors, VPAC1 and VPAC2, have similar affinities for PACAP and VIP (Harmar et al 1998). VPAC2 has been associated with VIP regulated ADNP expression in astrocytes (Zusev and Gozes 2004). While alternative splice variants of the PAC1 receptor have been associated with VIP neuroprotective activity (Pilzer and Gozes 2006).…”