Differential regulation of cocaine-induced locomotor activity in inbred long-sleep and short-sleep mice by dopamine and serotonin systems

Hanania, Taleen; McCreary, Andrew C.; Salaz, Danielle O; Lyons, Anne M.; Zahniser, Nancy R.

doi:10.1016/j.ejphar.2004.09.001

Cited by 7 publications

(3 citation statements)

References 54 publications

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“…In general, peripherally-administered cocaine results in decreased rearing behavior, although this effect is strain- and dose-dependent [21,22]. Measurement of rearing behavior is not possible with our CPP apparatus and strain differences in rearing behavior could have affected locomotor response; however, at least one study has shown dissociation between cocaine's effects on rearing and locomotor behaviors [23]. Stereotypy in response to cocaine is also dose- and strain-dependent.…”

Section: Discussionmentioning

confidence: 99%

Cocaine locomotor activation, sensitization and place preference in six inbred strains of mice

2011

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BackgroundThe expanding set of genomics tools available for inbred mouse strains has renewed interest in phenotyping larger sets of strains. The present study aims to explore phenotypic variability among six commonly-used inbred mouse strains to both the rewarding and locomotor stimulating effects of cocaine in a place conditioning task, including several strains or substrains that have not yet been characterized for some or all of these behaviors.MethodsC57BL/6J (B6), BALB/cJ (BALB), C3H/HeJ (C3H), DBA/2J (D2), FVB/NJ (FVB) and 129S1/SvImJ (129) mice were tested for conditioned place preference to 20 mg/kg cocaine.ResultsPlace preference was observed in most strains with the exception of D2 and 129. All strains showed a marked increase in locomotor activity in response to cocaine. In BALB mice, however, locomotor activation was context-dependent. Locomotor sensitization to repeated exposure to cocaine was most significant in 129 and D2 mice but was absent in FVB mice.ConclusionsGenetic correlations suggest that no significant correlation between conditioned place preference, acute locomotor activation, and locomotor sensitization exists among these strains indicating that separate mechanisms underlie the psychomotor and rewarding effects of cocaine.

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Section: Discussionmentioning

confidence: 99%

Cocaine locomotor activation, sensitization and place preference in six inbred strains of mice

2011

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“…In fact, numerous labs have shown that genetic differences between ILS and ISS in 5HT, DA, norepinephrine, GABA, and NMDA (Hanania et al, 2000, 2004; Hanania & Zahniser, 2002; Haughey et al, 2005; Proctor et al, 2004; Zahniser et al, 1992) receptors may be responsible for habituation (or lack thereof) of the HPA-axis response to stress and underlie their differing sensitivity to ethanol following stress or glucocorticoid injection. Further research using the ILS and ISS strains to determine how these neural systems are differentially regulated by stress exposure might prove fruitful in further elucidating genes and gene networks involved in stress and ethanol sensitivity.…”

Section: Discussionmentioning

confidence: 99%

Restraint stress and exogenous corticosterone differentially alter sensitivity to the sedative-hypnotic effects of ethanol in inbred long-sleep and inbred short-sleep mice

Parker

Ponicsan

Spencer

et al. 2008

Alcohol

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Decreased sensitivity to ethanol is a genetically mediated trait implicated in susceptibility to developing alcoholism. Here, we explore genotype by environment differences in ethanol sensitivity. The relationship between acute- and repeated-restraint stress, corticosterone (CORT) levels, and sensitivity to sedative-hypnotic properties of ethanol was explored using inbred long-sleep (ILS) and inbred short-sleep (ISS) mice. In ILS mice, acute restraint decreased ethanol sensitivity at a 4.1 g/kg dose, as measured by a decrease in the duration of loss of the righting reflex (LORE) and an increase in blood ethanol concentration at regain of the righting response (BECRR). Repeated restraint also decreased LORE duration, but had no effect on BECRR. In the ISS mice, there was no effect of acute restraint on either LORE duration or BECRR. However, repeated restraint increased ethanol sensitivity at a 4.1 g/kg dose; with an increase in LORE duration, but a decrease in BECRR. Differences in hypothalamic-pituitary-adrenal (HPA) axis responsiveness to restraint stress (as measured by plasma CORT) were also examined between genotypes. ILS mice displayed habituation to repeated restraint, whereas ISS mice did not. Lastly, the effect of enhanced CORT levels independent of psychological stress was examined for its effects on the sedative-hypnotic effects of ethanol. There were no effects of CORT pretreatment on LORE duration or BECRR in ILS mice compared to saline- or noninjected littermates. In contrast, ISS mice injected with CORT showed a decreased duration of LORE, but no effects on BECRR. These findings suggest that in addition to genetic susceptibility, environmental factors (e.g., restraint stress, exogenous CORT administration) also influence sensitivity to the sedative effects of ethanol through alteration of central nervous system sensitivity and pharmacokinetic parameters, and do so in a genotype-dependent manner.

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“…These neurotransmission signaling systems may also modulate the reinforcing or rewarding effects of abusable drugs through other neurotransmitter systems, providing a key psychomotor mechanism of the development of DD. For example, (i) the psychomotor stimulant effects of cocaine are most often thought to be mediated through enhanced dopamine or serotonin neurotransmission in mesolimbic areas of the brain (30)(31)(32). Blockade of the D3 receptor in the mesolimbic system with SB-277011A, a novel D3-selective antagonist, attenuates cocaine-enhanced brain stimulation reward, cocaine-induced conditioned place preference and cocaineinduced reinstatement of cocaine-seeking behavior in rats (33).…”

Section: Discussionmentioning

confidence: 99%

Multiple ADH genes modulate risk for drug dependence in both African- and European-Americans

Luο

Kranzler

Zuo

et al. 2006

Human Molecular Genetics

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Drug dependence (DD) is commonly co-morbid with alcohol dependence (AD). Many studies have also shown common genetic risk factors for these disorders. We previously reported associations of AD with seven alcohol dehydrogenase (ADH) genes. The present study examines the relationship between these genes and DD. We genotyped 16 markers within the ADH gene cluster and 38 unlinked ancestry-informative markers in a case-control sample of 718 individuals. All markers were consistent with Hardy-Weinberg equilibrium in controls, but some markers showed Hardy-Weinberg disequilibrium in cases (minimal P = 0.002). Genotypes of many markers were associated with DD, both before and after controlling for admixture effects (minimal P < 1.0 x 10(-6)). Diplotype trend regression analysis showed that ADH5 and ADH6 genotypes, and diplotypes at ADH1A, ADH1B, ADH1C and ADH7 (minimal P = 0.002), were associated with DD in European-Americans and/or African-Americans. This first report of an allelic association of these loci with DD provides new insight into the mechanism of genetic risk for DD. These findings, obtained using a series of powerful and reliable analytic methods, may also help to explain the high rate of co-morbidity between AD and DD.

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Differential regulation of cocaine-induced locomotor activity in inbred long-sleep and short-sleep mice by dopamine and serotonin systems

Cited by 7 publications

References 54 publications

Cocaine locomotor activation, sensitization and place preference in six inbred strains of mice

Cocaine locomotor activation, sensitization and place preference in six inbred strains of mice

Restraint stress and exogenous corticosterone differentially alter sensitivity to the sedative-hypnotic effects of ethanol in inbred long-sleep and inbred short-sleep mice

Multiple ADH genes modulate risk for drug dependence in both African- and European-Americans

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