Differential roles of alterations of p53, p16, and SMAD4 expression in the progression of intraductal papillary-mucinous tumors of the pancreas

Sasaki, Shigeru; Yamamoto, Hiroyuki; Kaneto, Hiroyuki; Ozeki, Itaru; Adachi, Yasuyo; Takagi, Hideyasu; Matsumoto, Takeshi; Itoh, Hideto; Nagakawa, Tatsuya; Miyakawa, Hiroyoshi; Muraoka, Shunji; Fujinaga, Atsuro; Suga, Toshihiro; Satoh, Masaaki; Itoh, Fumio; Endo, Takao; Imai, Kohzoh

doi:10.3892/or.10.1.21

Cited by 45 publications

(37 citation statements)

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“…So far, genetic analyses of IPMN have disclosed abnormalities in many of the same genes altered in conventional ductal adenocarcinoma, including mutations of KRAS [44], TP53/p53 [71], and CDKN2A/p16 genes [72]. In addition, as is true for pancreatic ductal carcinomas, a number of genes, including CDKN2A/p16, may be epigenetically inactivated in IPMN through aberrant DNA methylation [53,54,73,74].…”

Section: Discussionmentioning

confidence: 99%

PIK3CA, KRAS, and BRAF mutations in intraductal papillary mucinous neoplasm/carcinoma (IPMN/C) of the pancreas

Schönleben

Qiu

Remotti

et al. 2008

Langenbecks Arch Surg

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Section: Discussionmentioning

confidence: 99%

PIK3CA, KRAS, and BRAF mutations in intraductal papillary mucinous neoplasm/carcinoma (IPMN/C) of the pancreas

Schönleben

Qiu

Remotti

et al. 2008

Langenbecks Arch Surg

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“…Veränderungen im K-ras-Gen wurden mit einer Frequenz von 31% bei IPMN beschrieben [52]. Zudem fanden sich in einem Teil der Fälle ebenso Genmutationen im p16-und im p53-Gen [53,54]. Der Verlust des Tumorsuppressorgens DPC4 scheint nur bei invasiven Komponenten der IPMN vorhanden zu sein und selten aufzutreten [55,56].…”

Section: Molekulargenetische Aspekte Der Ipmnunclassified

Intraepitheliale Neoplasien (PanIN) und intraduktale papillär-muzinöse Neoplasien (IPMN) des Pankreas als Vorläufer des Pankreaskarzinoms

Ott¹,

Heinmöller

Gäumann

et al. 2007

Med Klin

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Due to the fatal prognosis of pancreatic carcinoma, great efforts have been made to investigate precursor lesions of invasive neoplasia during the last few years. Pancreatic intraepithelial neoplasias (PanIN) have been recognized as precursor lesions of ductal adenocarcinoma, and are classified into different grades from PanIN-1A, -1B, -2, to -3. Molecular analyses have helped to define a progression model for pancreatic neoplasia. The most important step seems to be the occurrence of a PanIN-3 lesion defining a high risk of malignant transformation. As in PanINs, different types of intraductal papillary-mucinous neoplasms (IPMN) can be discriminated ranging from benign to invasive lesions. Becoming invasive, some of these tumors appear as ductal adenocarcinoma, others as colloid carcinoma with a much better prognosis. In this review, the characteristics of these two precursor lesions and their genetic alterations are summarized.

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“…The prevalence of malignancy in branch-duct IPMN has been observed in up to 20% [13]. The prevalence of invasive carcinoma as reported in MCN varies between 6% and 36% [14][15][16]. A (Table 1).…”

Section: Introductionmentioning

confidence: 99%

Duodenum-preserving total pancreatic head resection for cystic neoplasm—a limited but cancer-preventive procedure

Beger

Rau

Gansauge

et al. 2008

Langenbecks Arch Surg

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A duodenum-preserving total pancreatic head resection is a limited surgical procedure for patients who suffer a local monocentric, cystic neoplastic lesion in the pancreatic head. Absence of an advanced pancreatic cancer and completeness of extirpation of the benign tumor determine the long-term outcome. In regards to the location of the lesion in the pancreatic head, several modifications have been applied with low hospital morbidity and mortality below 1%.

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Differential roles of alterations of p53, p16, and SMAD4 expression in the progression of intraductal papillary-mucinous tumors of the pancreas

Cited by 45 publications

References 0 publications

PIK3CA, KRAS, and BRAF mutations in intraductal papillary mucinous neoplasm/carcinoma (IPMN/C) of the pancreas

PIK3CA, KRAS, and BRAF mutations in intraductal papillary mucinous neoplasm/carcinoma (IPMN/C) of the pancreas

Intraepitheliale Neoplasien (PanIN) und intraduktale papillär-muzinöse Neoplasien (IPMN) des Pankreas als Vorläufer des Pankreaskarzinoms

Duodenum-preserving total pancreatic head resection for cystic neoplasm—a limited but cancer-preventive procedure

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