Differential sensitivity to SSRI and tricyclic antidepressants in juvenile and adult mice of three strains

Mason, Sara S.; Baker, Kevin B.; Davis, Kristina W.; Pogorelov, Vladimir M.; Malbari, Murtaza M.; Ritter, Ruth A.; Wray, Stephen P.; Gerhardt, Brenda; Lanthorn, Thomas H.; Savelieva, Katerina V.

doi:10.1016/j.ejphar.2008.11.010

Cited by 47 publications

(40 citation statements)

References 75 publications

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“…Adolescent (P28 and P35) mice also respond to the anti-immobility effects of imipramine and DMI in the TST (Mason et al, 2009;Mitchell et al, 2013), and DMI reduces immobility time in the FST in adolescent (P28 and P30) rats (Pechnick et al, 2008;Reed et al, 2008). Our SERT1/1 mouse data agree with literature showing that adolescents (P28) are sensitive to the antidepressant-like effects of DMI .…”

Section: Discussionsupporting

confidence: 82%

“…The TCA imipramine, a NET and SERT blocker, is known to reduce immobility time of adolescent mice (P28 and P35) in the FST, an assay of antidepressant-like response (Bourin et al, 1998;David et al, 2001;Mason et al, 2009). Adolescent (P28 and P35) mice also respond to the anti-immobility effects of imipramine and DMI in the TST (Mason et al, 2009;Mitchell et al, 2013), and DMI reduces immobility time in the FST in adolescent (P28 and P30) rats (Pechnick et al, 2008;Reed et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

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Ontogeny of Norepinephrine Transporter Expression and Antidepressant-Like Response to Desipramine in Wild-Type and Serotonin Transporter Mutant Mice

Mitchell

Bowman

Gould

et al. 2016

J Pharmacol Exp Ther

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Depression is a major public health concern with symptoms that are often poorly controlled by treatment with common antidepressants. This problem is compounded in juveniles and adolescents, because therapeutic options are limited to selective serotonin reuptake inhibitors (SSRIs). Moreover, therapeutic benefits of SSRIs are often especially limited in certain subpopulations of depressed patients, including children and carriers of low-expressing serotonin transporter (SERT) gene variants. Tricyclic antidepressants (TCAs) offer an alternative to SSRIs; however, how age and SERT expression influence antidepressant response to TCAs is not understood. We investigated the relation between antidepressant-like response to the TCA desipramine using the tail suspension test and saturation binding of [P21]), adolescent (P28), and adult (P90) wild-type (SERT1/1) mice. To model carriers of low-expressing SERT gene variants, we used mice with reduced SERT expression (SERT1/2) or lacking SERT (SERT2/2). The potency and maximal antidepressant-like effect of desipramine was greater in P21 mice than in P90 mice and was SERT genotype independent. NET expression decreased with age in the locus coeruleus and increased with age in several terminal regions (e.g., the cornu ammonis CA1 and CA3 regions of the hippocampus). Binding affinity of [ 3 H]nisoxetine did not vary as a function of age or SERT genotype. These data show age-dependent shifts for desipramine to produce antidepressant-like effects that correlate with NET expression in the locus coeruleus and suggest that drugs with NET-blocking activity may be an effective alternative to SSRIs in juveniles.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Ontogeny of Norepinephrine Transporter Expression and Antidepressant-Like Response to Desipramine in Wild-Type and Serotonin Transporter Mutant Mice

Mitchell

Bowman

Gould

et al. 2016

J Pharmacol Exp Ther

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show abstract

“…This definition is arbitrary and cannot be used in any automated procedure of immobility evaluation. Other definition of immobility is based on some threshold values of animal's movements when an animal is judged to be immobile when the velocity of its center less than 2 cm/s (Crowley et al, 2004) or the intensity of movement of its paws less than 450 (Mason et al, 2009). Although these threshold definitions can be used for automation of the FST, they are not constructive because no biological or statistical ground for the threshold choice has been presented.…”

Section: Discussionmentioning

confidence: 99%

“…In the existing automated version of the FST the immobility state was qualified by the horizontal velocity of the mouse center (Crowley et al, 2004) or by the intensity of the mouse paws movements (Mason et al, 2009). In the present study we proposed to qualify immobility state by mouse silhouette alteration.…”

Section: Discussionmentioning

confidence: 99%

“…However, a low horizontal velocity is not an adequate measure of immobility, since it does not include climbing behavior. Other authors used the VideoTrack Quantization software and animal activity was classified according to a threshold algorithm by the following states: immobility (<450), swimming (450-750) and struggling (>750) (Mason et al, 2009). However, the authors did not present any biological or statistical grounds for the threshold choice.…”

Section: Introductionmentioning

confidence: 99%

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