Differential serum cytokine levels are associated with cytokine gene polymorphisms in north Indians with active pulmonary tuberculosis

Abhimanyu, Abhimanyu; Mangangcha, Irengbam Rocky; Jha, Pankaj; Arora, Karan; Mukerji, Mitali; Banavaliker, Jayant Nagesh; Brahmachari, Vani; Bose, Mridula

doi:10.1016/j.meegid.2011.03.017

Cited by 35 publications

(37 citation statements)

References 47 publications

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“…Previous studies have reported that cytokine genes contribute to susceptibility of TB, such as interferon-1β, interleukin (IL)-3, IL-6, IL-10, and IL-12B IL-17 as well as IL-18 (Selvaraj et al, 2008;Abhimanyu et al, 2011;Meenakshi et al, 2013;Feng et al, 2014;Tiwari et al, 2014;Zhang et al, 2014). However, the results have been inconsistent.…”

Section: Introducionmentioning

confidence: 99%

Influence of interleukin-17 gene polymorphisms on the development of pulmonary tuberculosis

Shi¹,

Zhang²

2015

Genet. Mol. Res.

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ABSTRACT. We conducted a case-control study in a Chinese population to examine the correlations between interleukin (IL)-17 gene polymorphisms and tuberculosis (TB) development. The study population included 336 TB subjects and 351 control subjects who were enrolled between June 2012 and June 2014. Genotyping analyses of IL-17A rs2275913 and rs3748067 and IL-17F rs763780 were analyzed using polymerase chain reaction-restriction fragment length of polymorphism. The genotype distributions of IL-17 rs2275913 were found to be in Hardy-Weinberg equilibrium in the controls, while the IL-17 rs3748067 and rs763780 were not. Based on unconditional logistic regression, individuals carrying the AA genotype and GA + AA genotype of rs2275913 were more likely to have a significantly increased risk of TB compared to subjects with the GG genotype. The ORs (95%CI) for the AA genotype and GA + AA genotype were 2.20 (1.35-3.60) and 1.52 (1.11-2.09), respectively. The CC genotype and TC + CC genotype of rs763780 were associated with increased risk of TB when compared with the TT genotype. The ORs (95%CI) for the CC genotype and TC + CC genotype were 1.99 (1.05-3.87) and 1.58 (1.07-2.33), respectively. In conclusion, rs763780 may play a critical role in the etiology of TB.

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Section: Introducionmentioning

confidence: 99%

Influence of interleukin-17 gene polymorphisms on the development of pulmonary tuberculosis

Shi¹,

Zhang²

2015

Genet. Mol. Res.

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“…IFN-γ +874 T>A tek nükleotid polimorfizmi için bunun gibi birbiriyle uyumlu olmayan sonuçlara ülkemizde 23,25,27,28 ve Hindistan'da 8,29 yapılan çalışmalarda da rastlanmıştır. Yine, Hindistan'da TNF-α geni promotor -308 G>A tek nükleotid polimorfizm varlığı ile ilgili yapılan çalışmalarda birbiriyle uyumlu olmayan sonuçlar bildirilmiştir 3,30 . Ülkemizde bu gen bölgesindeki polimorfizm varlı-ğı ile ilgili yapılan çalışmalarda, bizim çalışmamızda olduğu gibi, istatistiksel olarak anlamlı bir ilişkinin tespit edilemediği belirtilmiştir [23][24][25] .…”

Section: M‹krob‹yoloj‹ Bülten‹unclassified

“…Bu çalışma sonucunda allel ve genotip dağılım-larında hasta ve sağlıklı kontrol grubu arasında istatistiksel olarak anlamlı bir farklılık gö-rülmemekle birlikte, bu sonuçların ülkemizin epidemiyolojik verilerine önemli katkıda bulunacağı düşünülmüştür. Hindistan 8 ve İran'da 9 akciğer TB'li hastalar ve sağlıklı kontrollerde yapılan çalışmalarda, bu gen bölgesindeki tek nükleotid polimorfizmi ile TB'ye genetik yatkınlık arasında istatistiksel olarak anlamlı ilişkinin olduğu bildirilmekle birlikte, yine Hindistan'da yapılan iki farklı çalışmada genetik yatkınlık ile ilgili istatistiksel olarak anlamlı bir ilişkinin saptanamadığı belirtilmektedir 3,35 .…”

Section: Resim 2 Pcr-rflp üRünlerinin Agaroz Jel Elektroforez Görüntunclassified

“…M.tuberculosis enfeksiyonu sırasında, basile maruziyetin üçüncü haftasında salgılanan ve makrofajları aktive eden Th1 tipi sitokinlerin koruyucu immünitede çok önemli oldukları gösterilmiştir 3 . Bunlardan birisi olan interferon gama (IFN-γ), makrofaj aktivasyonu ve MHC sınıf II ile birlikte antitümör ve antimikrobisidal aktivitelerin uyarılmasındaki en önemli sitokindir 3 . IFN-γ geninde mutasyon bulunan kişiler, M.tuberculosis ve patojenik olmayan mikobakteri enfeksiyonlarına karşı duyarlıdırlar.…”

Section: Introductionunclassified

“…TNF-α ayrıca mikobakteriyel enfeksiyonlara karşı oluşturulan yanıtta apoptozun başlatılmasında gereklidir. TNF-α geni promotor -1031 T> sitozin (C), -863 C>A, -857 T>C, -308 G>A ve -238 G>A tek nükleotid polimorfizmleri ile TB'ye duyarlılık arasındaki ilişkiyi gösteren çeşitli çalış-malar bulunmaktadır 3 . İnterlökin (IL)-12, p35 ve p40 alt ünitelerinden oluşan heterodimerik bir sitokin olup, IL-12A geni p35, IL-12B geni ise p40 alt ünitesini kodlar 5 .…”

Section: Introductionunclassified

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Determination of the Cytokine Gene Polymorphism and Genetic Susceptibility in Tuberculosis Patients

Ülger¹,

Emekdaş²,

Aslan³

et al. 2013

Mikrobiyol Bul

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Assessment of serum level of interleukin-1β and interleukin-12 in leprosy: impact of previous Bacillus Calmitte Guerin vaccination

2013

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Macrophages play an important role in attempt to eliminate mycobacteria, via production of cytokines, including interleukin-1, and interleukin-12. Bacillus Calmitte Guerin (BCG) vaccination, known to induce interleukin-1β in tuberculosis, was originally aimed at tuberculosis control, but it showed efficacy against leprosy. Our aim was to estimate serum levels of interleukin-1β and interleukin-12, in leprosy, and to assess the impact of previous BCG vaccination on their levels. Serum interleukin-1β and interleukin-12 p70 were estimated in 43 leprotic patients and 43 controls by enzyme-linked immunosorbent assay. Patients were grouped according to presence or absence of reactions, as well as bacillary load. Serum interleukin-1β was significantly higher in patients as compared to controls (p = 0.047), and was significantly different in patients' groups (p = 0.036); with significantly higher level in multibacillary patients, both non reactional and with erythema nodosum leprosum, compared with paucibacillary/non reactional patients (p = 0.012 and 0.049 respectively). A statistically significant higher interleukin-1β was found in BCG vaccinated paucibacillary patients as compared to unvaccinated patients (p = 0.031). Significantly elevated interleukin-12 was present in patients as compared to controls (p < 0.001), with no statistically significant difference comparing patients' groups. BCG vaccination showed stimulatory effect on monocytes only in the immunocompetent paucibacillary leprosy patients, as evidenced by higher Interleukin-1β in this group. Interleukin-1β was shown to have a pro-inflammatory role in multibacillary patients with or without erythema nodosum leprosum. Targeting interleukin-1β may be promising to control episodic refractory erythema nodosum leprosum. Interleukin-12 may be a general marker of active Mycobacterium leprae infection.

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Differential serum cytokine levels are associated with cytokine gene polymorphisms in north Indians with active pulmonary tuberculosis

Cited by 35 publications

References 47 publications

Influence of interleukin-17 gene polymorphisms on the development of pulmonary tuberculosis

Influence of interleukin-17 gene polymorphisms on the development of pulmonary tuberculosis

Determination of the Cytokine Gene Polymorphism and Genetic Susceptibility in Tuberculosis Patients

Assessment of serum level of interleukin-1β and interleukin-12 in leprosy: impact of previous Bacillus Calmitte Guerin vaccination

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