Differential Toxicity of Alkylphenols in JEG-3 Human Placental Cells: Alteration of P450 Aromatase and Cell Lipid Composition

Pérez-Albaladejo, Elisabet; Lacorte, Sı́lvia; Porte, Cinta

doi:10.1093/toxsci/kfy243

Cited by 27 publications

(22 citation statements)

References 49 publications

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“…21 This hypothesis is further supported by previous results observed in-vitro, where a general depletion of polyunsaturated lipids, namely PCs (36:5, 38:5, 38:6), PC-Ps and PEs/PE-Ps were detected both, in PLHC-1 and JEG-3 cells exposed to compounds that significantly induced the generation of ROS. 22 . However, other hypothesis like the reduced biosynthesis of highly unsaturated lipids in fish from polluted sites cannot be discarded.…”

Section: Methodsmentioning

confidence: 99%

Skeletal Muscle Lipidomics as a New Tool to Determine Altered Lipid Homeostasis in Fish Exposed to Urban and Industrial Wastewaters

Marqueño

Blanco

Maceda‐Veiga

et al. 2019

Environ. Sci. Technol.

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This work applies ultra-high performance liquid chromatography coupled to highresolution mass spectrometry (UPLC-HRMS) to characterize for the first time the lipidome of the skeletal muscle of two fish species (Barbus meridionalis, Squalius laietanus) collected in a Mediterranean River affected by urban and industrial wastewater outflows. The untargeted analysis allowed a clear separation of the lipidome of fish from polluted and reference sites; phosphatidylcholines (PCs), phosphatidylethanolamines (PEs) and their lyso and ether-linked forms were among the distinctive features. The targeted analysis consistently detected a decrease in PC

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Section: Methodsmentioning

confidence: 99%

Skeletal Muscle Lipidomics as a New Tool to Determine Altered Lipid Homeostasis in Fish Exposed to Urban and Industrial Wastewaters

Marqueño

Blanco

Maceda‐Veiga

et al. 2019

Environ. Sci. Technol.

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“…These descriptor sets are obtained by removing the size descriptors (17)(18)(19)(20) from DS-A and DS-B, respectively. C * (4) pIGC 50 * ¼ 0:781EAv * þ 0:520eLUMO * þ0:435Sð1 orb Þ * À 0:220lS0 ! A * À 0:424IPv * À 0:318lS0 !…”

Section: Full Papermentioning

confidence: 99%

“…[3] They are being used as non-ionic surfactants, emulsifier, lubricant, or antioxidant in a variety of products such as laundry detergents, textiles, leather, paints, disinfecting cleaner, spot removers, hair colouring, cosmetic, adhesive, plastics, and pesticides. [4] It has been reported that APs are accumulated in lipids, bind to proteins, cause acute cytotoxicity and oxidative stress, cutaneous diseases such as vitiligo, and act as endocrine disrupters. [4] It has been reported that APs are accumulated in lipids, bind to proteins, cause acute cytotoxicity and oxidative stress, cutaneous diseases such as vitiligo, and act as endocrine disrupters.…”

Section: Introductionmentioning

confidence: 99%

An Electronic‐structure Informatics Study on the Toxicity of Alkylphenols toTetrahymena pyriformis

Sugimoto

Manggara

Yoshida

et al. 2020

Molecular Informatics

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Alkylphenols (APs) dissolved in water are known to be toxic to animals including humans. In this study, regression models describing the toxicity of the 33 AP molecules were investigated for reproducing and thereby making it possible to predict a quantitative structureactivity relationship (QSAR). For this purpose, we tried to derive regression models for the experimental IGC 50 (growth inhibition concentration at 50 %) to Tetrahymena pyriformis by using various descriptor sets consisting of electronic and shape descriptors. By applying the multiple linear regression (MLR) analysis, it was successful to derive a quantitative regression model for the IGC 50 values. In this analysis, the size parameters of the molecules were found important, suggesting that bulky molecules should be less toxic. We could also obtain, when the size descriptors were excluded, an MLR model indicating that the electron affinity (EA) should be important, which is consistent with the previous QSAR studies. Through the correlation analysis among the descriptors, it was shown that, in the present set of molecules, EA and a size parameter are highly correlated. Since EA was calculated to be negative, indicating that the related process would be energetically unfavourable, it was concluded that the size of the molecules should be a dominant factor determining IGC 50 . This implies that a molecular recognition process would play a critical role in the mode of action for the toxicity.

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“…Obesogenic properties have been associated with alkylphenols (derivatives of alkylphenol ethoxylates), which are nonionic surfactants that are used as cleaning agents [22]. There is also a body of evidence for the obesogenic effects of the pesticide dichlorodiphenyltrichloroethane (DDT) and its metabolite dichlorodiphenyldichloroethylene (DDE) [23].…”

Section: Sources and Classes Of Obesogensmentioning

confidence: 99%

Role of Obesogens in the Pathogenesis of Obesity

et al. 2019

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Obesity is considered to be a 20th century pandemic, and its prevalence correlates with the increasing global pollution and the presence of chemical compounds in the environment. Excessive adiposity results from an imbalance between energy intake and expenditure, but it is not merely an effect of overeating and lack of physical activity. Recently, several compounds that alter the mechanisms responsible for energy homeostasis have been identified and called “obesogens”. This work presents the role of obesogens in the pathogenesis of obesity. We reviewed data from in vitro animal and human studies concerning the role of obesogens in the disturbance of energy homeostasis. We identified (i) the main groups and classes of obesogens, (ii) the molecular mechanisms of their action, (iii) their deleterious effect on adipose tissue function and control of appetite, and (iv) possible directions in limiting their influence on human metabolism. Obesogens have a multifactorial detrimental influence on energy homeostasis. Focusing on limiting exposure to obesogens and improving early life nutrition seems to be the most reasonable direction of action to prevent obesity in future generations.

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Differential Toxicity of Alkylphenols in JEG-3 Human Placental Cells: Alteration of P450 Aromatase and Cell Lipid Composition

Cited by 27 publications

References 49 publications

Skeletal Muscle Lipidomics as a New Tool to Determine Altered Lipid Homeostasis in Fish Exposed to Urban and Industrial Wastewaters

Skeletal Muscle Lipidomics as a New Tool to Determine Altered Lipid Homeostasis in Fish Exposed to Urban and Industrial Wastewaters

An Electronic‐structure Informatics Study on the Toxicity of Alkylphenols toTetrahymena pyriformis

Role of Obesogens in the Pathogenesis of Obesity

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