Differential twin concordance for multiple sclerosis by latitude of birthplace

Islam, Talat; Gauderman, W. James; Cozen, Wendy; Hamilton, Ann S.; Burnett, Margaret; Mack, Thomas M.

doi:10.1002/ana.20871

Cited by 99 publications

(98 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We first demonstrated that twin concordance for multiple sclerosis was higher among MZ compared with DZ twins as expected, but the MZ:DZ concordance ratio was also increased by North European ancestry, younger age at diagnosis, and Northern latitude of birth (Islam et al, 2006), indicating gene-environment interaction. We then showed that sun exposure modified the risk of multiple sclerosis within disease-discordant MZ pairs (Islam et al, 2007).…”

Section: Multiple Sclerosissupporting

confidence: 59%

The USC Adult Twin Cohorts: International Twin Study and California Twin Program

et al. 2012

Self Cite

View full text Add to dashboard Cite

The study of twin subjects permits the documentation of crude heritability and may promote the identification of specific causal alleles. We believe that at the current time, the chief research advantage of twins as subjects, especially monozygotic twins, is that the commonality of their genetic and cultural identity simplifies the interpretation of biological associations. In order to study genetic and environmental determinants of cancer and chronic diseases, we developed two twin registries, maintained at the University of Southern California: The International Twin Study (ITS) and the California Twin Program (CTP). The ITS is a volunteer registry of twins with cancer and chronic disease consisting of 17,245 twin pairs affected by cancer and chronic disease, respectively, ascertained by advertising in periodicals from 1980–1991. The CTP is a population-based registry of California-born twin pairs ascertained by linking the California birth records to the State Department of Motor Vehicles. Over 51,000 individual California twins representing 36,965 pairs completed and returned 16-page questionnaires. Cancer diagnoses in the California twins are updated by regular linkage to the California Cancer Registry. Over 5,000 cancer patients are represented in the CTP. Twins from both registries have participated extensively in studies of breast cancer, melanoma, lymphoma, multiple sclerosis, systemic lupus erythematosus, diabetes mellitus type 1, mammographic density, smoking, and other traits and conditions.

show abstract

Section: Multiple Sclerosissupporting

confidence: 59%

The USC Adult Twin Cohorts: International Twin Study and California Twin Program

et al. 2012

Self Cite

View full text Add to dashboard Cite

show abstract

“…The percentage of concordance for monozygotic twins is approximately 25-30% whereas the concordance percentage for dizygotic twins is 3-5% (Ebers et al, 1986(Ebers et al, , 1995(Ebers et al, , 2004Mumford et al, 1994;Willer et al, 2003;Hansen et al, 2005;Islam et al, 2006;Ristori et al, 2006). This concordance rate for fraternal twins is greater than that of other first-degree relatives of MS patients but is still far less than that of identical twins (Willer et al, 2003).…”

Section: Twin Studiesmentioning

confidence: 99%

Multiple sclerosis genetics

Cree

2014

Handbook of Clinical Neurology

View full text Add to dashboard Cite

“…Indeed, genetic epidemiological studies strongly support this. 10 It would have been of interest had the authors of the present study been able to incorporate a measure of vitamin D status along with their analysis of HLA-DRB1 alleles, however this is not an easy thing to do. More generally, epidemiological, functional, and genetic data are making a role for vitamin D in MS aetiology broadly unequivocal.…”

mentioning

confidence: 98%