Vitamin D and multiple sclerosis: an interaction between genes and environment

Handel, Adam E.; Ramagopalan, Sreeram

doi:10.1177/1352458511418353

Cited by 13 publications

(7 citation statements)

References 9 publications

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“…These differences in outcomes might be explained by a large variation in inclusion numbers, different outcome assessment scales and variation in geographical distribution with concomitant genetic variations. Interestingly, an interaction between vitamin D and genes has been suggested in MS . Of additional notice, in contrast to our study, none of the before‐mentioned studies exploring the association between vitamin D and fatigue and neuropsychiatric symptoms took sun exposure into account.…”

Section: Discussioncontrasting

confidence: 90%

Higher levels of reported sun exposure, and not vitamin D status, are associated with less depressive symptoms and fatigue in multiple sclerosis

Knippenberg

Damoiseaux

Bol³

et al. 2013

Acta Neurol Scand

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Section: Discussioncontrasting

confidence: 90%

Higher levels of reported sun exposure, and not vitamin D status, are associated with less depressive symptoms and fatigue in multiple sclerosis

Knippenberg

Damoiseaux

Bol³

et al. 2013

Acta Neurol Scand

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“…In contrast, in the association between HLA and VDR variants in MS, we found that the combination the “ A ” allele of ApaI and the HLA‐DRB1*15:01 haplotype confers susceptibility to MS in a Japanese population, and the same observation was reported in a Spanish population . These results suggest that the functional mechanism linking VDR ‐mediated signaling and HLA‐DRB1*15 expression might be implicated in disease susceptibility …”

Section: Vitamin D‐related Genetic Studies In Multiple Sclerosiscontrasting

confidence: 50%

Vitamin D and multiple sclerosis in Asians and Caucasians: environmental and genetic aspects

Niino

Miyazaki

Fukazawa

et al. 2013

Clinical & Exp Neuroim

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Several genetic and environmental factors are thought to be associated with an increased risk of multiple sclerosis (MS), the influence of which can differ between ethnicities. One of the most important risk factors for MS is low serum levels of vitamin D, and these levels also differ between ethnicities, probably mainly because of differences in skin pigmentation. Furthermore, genetic influences in vitamin D-related genes might also vary between ethnicities, reflecting different genetic backgrounds. The present review article discusses the association between vitamin D and MS, with a focus on Asians and Caucasians. (Clin. Exp. Neuroimmunol.

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“…23-25 A growing body of work suggests that the level of serum 25-hydroxyvitamin D (25-OH-D) [26][27][28][29][30] and Epstein-Barr virus (EBV) infection [31][32][33][34][35][36][37][38] collectively contribute to the pathogenesis of the disease. In order to control for genetic risk factors and uniquely examine the role of vitamin D and infectious agents on the onset of disease we investigated the status of serum 25-hydroxyvitamin D (25-OH-D) and antibody titres against EBV, CMV and HHV-6 in a pair of discordant monozygotic twins.…”

Section: Introductionmentioning

confidence: 99%

Quantifying environmental risk factors for multiple sclerosis in discordant monozygotic twins: A case report

et al. 2015

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Relative contribution of genetic and environmental risk factors in complex disorders is widely explored through discordant identical twins. Multiple sclerosis is a demyelinating disease of the central nervous system in which the interplay of genetic and environmental risk factors define the disease pathogenicity. Robust epidemiological studies in different populations suggested that active levels of serum vitamin D and viral load implicate in MS pathogenicity and severity. In order to refine non-shared components of susceptibility factors in MS, we investigated the role of serum 25-hydroxyvitamin D and viral infection in a pair of identical twins remained discordant for MS during the course of 5 years follow up. Here we report serological finding regarding the viral load and serum 25-hydroxyvitamin D level in a pair of discordant monozygotic twins. Based on our observation, lower levels of serum 25-hydroxyvitamin D and higher anti-viral IgG titre was consistent with the disease statues in the affected sib. collectively contribute to the pathogenesis of the disease. In order to control for genetic risk factors and uniquely examine the role of vitamin D and infectious agents on the onset of disease we investigated the status of serum 25-hydroxyvitamin D (25-OH-D) and antibody titres against EBV, CMV and HHV-6 in a pair of discordant monozygotic twins. Keywords METHODA pair of discordant MZ twins were recruited from our registry of MS patients at the Kashani Hospital. The family pedigree and clinical features of the sib are provided in the Figure 1 and Table 1. For the affected individual McDonald's criteria of MS diagnosis was carefully fulfilled. Absence of MS complications in the health sib was also investigated through clinical evaluation and confirmed by MRI and immunologic assay. The subjects were fully informed about the study procedure and written consent was obtained.

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Vitamin D and multiple sclerosis: an interaction between genes and environment

Cited by 13 publications

References 9 publications

Higher levels of reported sun exposure, and not vitamin D status, are associated with less depressive symptoms and fatigue in multiple sclerosis

Higher levels of reported sun exposure, and not vitamin D status, are associated with less depressive symptoms and fatigue in multiple sclerosis

Vitamin D and multiple sclerosis in Asians and Caucasians: environmental and genetic aspects

Quantifying environmental risk factors for multiple sclerosis in discordant monozygotic twins: A case report

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