1996
DOI: 10.1002/(sici)1096-9896(199602)178:2<201::aid-path440>3.0.co;2-4
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Differentialin Situ Expression of the Genes Encoding the Chemokines McP-1 and Rantes in Human Inflammatory Bowel Disease

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Cited by 169 publications
(116 citation statements)
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“…Total IL-8 mRNA and protein are significantly up-regulated in colonic mucosa in Crohn disease and ulcerative colitis (38,(41)(42)(43) in direct proportion to the degree of inflammation (43). Moreover, IL-8 is constitutively up-regulated in a variety of human cancers such as bladder, gastric, and colorectal cancer (44 -47).…”
Section: Discussionmentioning
confidence: 99%
“…Total IL-8 mRNA and protein are significantly up-regulated in colonic mucosa in Crohn disease and ulcerative colitis (38,(41)(42)(43) in direct proportion to the degree of inflammation (43). Moreover, IL-8 is constitutively up-regulated in a variety of human cancers such as bladder, gastric, and colorectal cancer (44 -47).…”
Section: Discussionmentioning
confidence: 99%
“…Indeed, the mucosa of patients with IBD exhibited enhanced mRNA and protein expression of MCP-1/CCL2 (Reinecker et al, 1995;Mazzucchelli et al, 1996;Uguccioni et al, 1999), a CC-chemokine with potent chemotactic and activating activities for monocytes/ macrophages (Matsushima et al, 1989). They observed that CCL2 mRNA expression was enhanced in the colon of the AOM challenged mouse model, and that blocking the TNFa/TNFR axis reduced colorectal carcinogenesis, intracolonic macrophage infiltration and CCL2 mRNA expression (Popivanova et al, 2008).…”
Section: Chemokinesmentioning
confidence: 99%
“…f Ly6C low monocytes express CX3C-chemokine receptor 1 (CX3CR1) and possibly replenish the tissue-resident Mø and DC populations by responding to cleaved CX3C-chemokine ligand 1 (CX3CL1). Note that CX3CL1 (fractalkine) is expressed by intestinal epithelial and endothelial cells [101][102][103][104], while CCL2 is mainly produced at sites of mucosal inflammation [105]. Solid arrows represent pathways that are supported by published data, while dashed arrows indicate proposed, still hypothetical pathways.…”
mentioning
confidence: 92%