Diffuse Lung Uptake of 111In Octreotide from Chronic Emphysema

Abstract

A62-y-ol d woman was found to have a lung mass and a brain mass. The brain mass was resected, and the histopathologic findings were suggestive of a gastrointestinal primary tumor with neuroendocrine features. She was referred for an 111 In-octreotide SPECT/CT scan to evaluate for somatostatin-avid disease. After injection of 222 MBq (6 mCi) of 111 In-octreotide, planar SPECT images (Fig. 1A) and correlative CT images (Fig. 1B) of the chest were acquired in the anterior and posterior projections at the end of 4 h and 24 h. SPECT of the chest was also performed at the end of 24 h. An 18 F-FDG PET/CT scan (Fig. 1C) had been obtained 2 wk previously. QUESTION 1 On the basis of the 111 In-octreotide scan and correlative CT, what is the best interpretation of this study? A. 111 In-octreotide-avid tumor in the right lung and inflammatory changes bilaterally. B. Inflammatory changes. C. Normal findings. D. None of the above. FIGURE 1. (A) SPECT/CT scan obtained 24 h after injection of 222 MBq of 111 In-octreotide. (B) Correlative CT scan of chest. (C) 18 F-FDG PET/CT scan obtained 2 wk before 111 In-octreotide SPECT/CT scan.

Diffuse pancreatic neuroendocrine tumor: A rare presentation

“…[ 10 ] Diffuse pancreatic infiltration with neuroendocrine tumor is a rare presentation, previously reported once on anatomic imaging. [ 6 11 ] Diffuse uptake of In-111 pentetreotide has previously been reported in the lungs,[ 12 13 ] but diffuse uptake in the pancreas from a neuroendocrine tumor has not been reported previously. In conclusion, this case highlights a rare presentation of a well-differentiated, low-grade neuroendocrine tumor as the diffuse involvement of the pancreas, with local invasion, but no nodal or distant metastasis.…”

Mapping of Translocator Protein (18 kDa) in Peripheral Sterile Inflammatory Disease and Cancer through PET Imaging

“…Its multicellular expression is the primary problem noted in human lungs for TSPO PET imaging. Except for alveolar macrophages, it is also present in submucosal glands, pneumocytes, and the epithelial lining of the airways, but not in neutrophil expression. − TSPO has a pathogenic role in two obstructive respiratory diseases, asthma and chronic obstructive pulmonary disease (COPD), which entails accumulating inflammatory cells in the respiratory tract. Usually, COPD pathophysiology includes neutrophils, macrophages, and CD 8+ T cells that invade the respiratory tract and diverge from lung inflammation disorder, asthma involving excessive eosinophil, mast cell, and CD 4+ T cell formation in the airways .…”

TSPO PET Imaging: From Microglial Activation to Peripheral Sterile Inflammatory Diseases?

“…Moreover, invasive methods (e.g., lung biopsy and bronchoalveolar lavage) are unacceptable for repeat measurement in the context of longitudinal assessment for lung diseases [85]. Concerning single photon emission computed tomography (SPECT) scanning, although gamma-scintigraphy with 111 In- labelled granulocytes has been used to monitor migration of polynuclear cells into the lungs [86, 87], its metabolic activation and phenotype remain inaccessible with this nuclear exam [88]. …”