Diffuse progressive pulmonary interstitial and intra-alveolar cholesterol granulomas in childhood

Sato, Koichi; Takahashi, Hitoshi; Amano, Hiroshi; Uekusa, Toshimasa; Dambara, Takashi; Kira, Shintaro

doi:10.1183/09031936.96.09112419

Cited by 22 publications

(13 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to Skoric et al [7], the common Gram-positive organisms associated with lung granulomas are Corynebacterium sp., Mycobacterium sp., Nocardia sp., and Rhodococcus sp. Histopathology of a solitary lipogranuloma observed in the lung was similar to endogenous lipid granulomatous pneumonia in a human case reported by Sato et al [13]. However, in the present case, the source of the lipid could not be ascertained.…”

Section: Discussionsupporting

confidence: 66%

Occurrence of Granulomas in Bovines: An Abattoir-Based Study

Uma¹,

Nair²,

Varshney³

2011

ISRN Veterinary Science

View full text Add to dashboard Cite

The present study was carried out to record the occurrence of naturally occurring granulomas in cattle and buffaloes. Tissues grossly suspected for granulomas were collected from 336 out of 1600 (21%) abattoir cases. The gross features ranged from focal necrosis to large caseated masses, hard nodules, growths and abscesses. Histopathologically, 102 tissue samples (6.38%) were ascertained as granulomas. Majority of the granulomas were found in the liver 42 (41.18%), followed by lungs 22 (20.59%), lymph nodes 11 (10.78%), kidneys 6 (5.88%) and 14 (13.73%) as subcutaneous nodules/growths. Solitary cases were found in tongue, muscle, and urinary bladder, whereas 4 granulomas (3.92%) were found in body cavities. Based on the cellular component, the granulomas were categorized as epithelioid (53%), eosinophilic (37%) and suppurative (10%). Employing special staining techniques, the possible etiology of 75 granulomas could be identified. Among these, 70 granulomas (68.63%) were of infectious nature (parasitic 37 (36.28%), bacterial 32 (31.37%), and fungal 1(0.98%)). Non-infectious granulomas 5 cases (4.90%) included two lipid granulomas (1.96%), two granulomas (1.96%) associated with neoplasms and one (0.31%) associated with renal calculi. In 27 (26.47%) cases, the etiology of the granuloma could not be established and were categorized as granulomas of unknown etiology.

show abstract

Section: Discussionsupporting

confidence: 66%

Occurrence of Granulomas in Bovines: An Abattoir-Based Study

Uma¹,

Nair²,

Varshney³

2011

ISRN Veterinary Science

View full text Add to dashboard Cite

show abstract

“…Pathologic changes in the heart associated with lipid pneumonia have been described in humans. 19 In this case, lipid pneumonia was believed to be the major cause of respiratory failure. Although pleural effusion was noted, it has been reported in dogs and cats that 30 to 60 mL/kg of pleural effusion are required to produce respiratory compromise in the absence of parenchymal disease.…”

Section: Discussionmentioning

confidence: 95%

Endogenous Lipid Pneumonia in a Ferret (Mustela putorius furo)

Perpiñán

Ramis

2011

Journal of Exotic Pet Medicine

View full text Add to dashboard Cite

A 1-year-old female ferret was presented with an acute history of severe respiratory distress. Abnormal clinical signs noted during the initial physical examination were hypothermia, dehydration, pale mucous membranes, tachypnea, and severe dyspnea. Thoracic radiographs revealed pleural effusion, an enlarged cardiac silhouette, and areas of lung consolidation. Both blood and thoracic fluid were hyperproteinemic and hypergammaglobulinemic. Antibiotic, corticosteroid, and diuretic supportive treatment provided temporary improvement. After the initial positive response to treatment, the ferret's condition progressively deteriorated until the owners decided to euthanize the patient 15 days after initial presentation. Gross necropsy results revealed 5 mL of serosanguinous fluid within the thoracic cavity, cardiomegaly, and consolidated lungs that had a patchy, pale golden tissue pattern. The histologic diagnosis was endogenous lipid pneumonia. Findings suggest that endogenous lipid pneumonia can be associated with severe respiratory disease in ferrets.

show abstract

“…A case of coexistence of lipoid pneumonia and pulmonary alveolar proteinosis (PAP) has previously been reported [10]. PAP, specifically the primary type, is caused by anti-GM-CSF autoantibodies that lead to the development of lipid-laden alveolar macrophages and impaired surfactant lipoprotein clearance [11].…”

Section: Discussionmentioning

confidence: 99%

Intensive immunosuppressive therapy for endogenous lipoid pneumonia associated with rheumatoid arthritis

Morita

Arai

Kurasawa

et al. 2016

Modern Rheumatology

View full text Add to dashboard Cite

Endogenous lipoid pneumonia is an uncommon inflammatory pulmonary disease that is caused by lipids from an endogenous source, the treatment for which has not been established. We report the first case of endogenous lipoid pneumonia presenting as lung consolidation and which was associated with rheumatoid arthritis. Treatment was successful with intensive immunosuppressive therapy. When a physician finds lung consolidation in a patient with active rheumatic disease, lipoid pneumonia should be considered.

show abstract

Diffuse progressive pulmonary interstitial and intra-alveolar cholesterol granulomas in childhood

Cited by 22 publications

References 16 publications

Occurrence of Granulomas in Bovines: An Abattoir-Based Study

Occurrence of Granulomas in Bovines: An Abattoir-Based Study

Endogenous Lipid Pneumonia in a Ferret (Mustela putorius furo)

Intensive immunosuppressive therapy for endogenous lipoid pneumonia associated with rheumatoid arthritis

Contact Info

Product

Resources

About