Diffusion of nanoparticles within a semidilute polyelectrolyte solution

Senanayake, Kavindya; Shokeen, Namita; Fakhrabadi, Ehsan Akbari; Liberatore, Matthew W.; Mukhopadhyay, Ashis

doi:10.1039/c9sm01313j

Cited by 16 publications

(15 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…When it comes to bio‐sensing and drug‐delivery applications, the bulk properties of PEM films play a significant role in their optimal functionality. [ 27–36 ] Various bio‐molecules such as proteins, DNA, RNA can be integrated into the PEM stack via electrostatic interactions or other secondary interactions like hydrogen bonding, charge transfer interactions, chiral recognition, π – π interactions, and covalent bonding (click chemistry reactions). [ 9,37,46–50,38–45 ] Understanding the diffusion kinetics across a PEM stack is a major factor to be considered for employing them for biomolecular loading and release.…”

Section: Introductionmentioning

confidence: 99%

Simplifying Molecular Transport in Polyelectrolyte Multilayer Thin Films

Pahal

Boranna

Prashanth

et al. 2021

Macro Chemistry & Physics

View full text Add to dashboard Cite

The matrix properties of polyelectrolyte multilayer thin films (PEM) are critical in making them a viable candidate for various biomedical applications. The location and ability of molecules to diffuse through the PEM architecture determines their encapsulation and release capabilities in a given matrix for various biomedical applications. The main aim of this review article is to provide a complete understanding of molecular transport on the surface as well as across the bulk of the PEM matrix. Different physiochemical strategies to promote or suppress the diffusivity of various molecules inside the PEM are mentioned in brief. A set of guiding principles is uncovered for getting a complete picture of loading and release of molecules across the PEM structure, which can play a key role in designing a desirable PEM assembly and have important implications for designing multicomponent, targeted and controlled drug‐delivery vehicles. Understanding the molecular diffusivity in PEM stack at the nano and micro scales will help to design superior host materials for biomedical engineering applications.

show abstract

Section: Introductionmentioning

confidence: 99%

Simplifying Molecular Transport in Polyelectrolyte Multilayer Thin Films

Pahal

Boranna

Prashanth

et al. 2021

Macro Chemistry & Physics

View full text Add to dashboard Cite

show abstract

“…Both studies considered translational diffusion of electrostatically stabilized nanoparticles in model polyelectrolyte solutions. Senanayake and co-authors ( 27 ) studied translational diffusion of electrostatically stabilized anionic tannic acid–coated gold nanoparticles (sizes of 5, 20, and 40 nm) in polyacrylic acid (1000 kDa) solutions in distilled water (no salt). The authors reported polymer correlation lengths of 34 to 69 nm; therefore, their studies considered regimes where the particles are smaller or approximately the same size as the polymer correlation length.…”

Section: Discussionmentioning

confidence: 99%

“…Most of these nanoparticle diffusion studies have been done using flexible, neutral polymers or moderately flexible polymers like DNA ( 26 ). Comparatively fewer studies have been performed using polyelectrolyte solutions ( 20 , 27 , 28 ). Models based on obstruction effects, hydrodynamic theories, free volume theory, and length scale–dependent viscosity have been proposed to explain deviations from the Stokes-Einstein equation for nanoparticles undergoing diffusion in complex liquids ( 29 , 30 ).…”

Section: Introductionmentioning

confidence: 99%

Fast nanoparticle rotational and translational diffusion in synovial fluid and hyaluronic acid solutions

et al. 2021

View full text Add to dashboard Cite

Nanoparticles are under investigation as diagnostic and therapeutic agents for joint diseases, such as osteoarthritis. However, there is incomplete understanding of nanoparticle diffusion in synovial fluid, the fluid inside the joint, which consists of a mixture of the polyelectrolyte hyaluronic acid, proteins, and other components. Here, we show that rotational and translational diffusion of polymer-coated nanoparticles in quiescent synovial fluid and in hyaluronic acid solutions is well described by the Stokes-Einstein relationship, albeit with an effective medium viscosity that is much smaller than the macroscopic low shear viscosity of the fluid. This effective medium viscosity is well described by an equation for the viscosity of dilute polymer chains, where the additional viscous dissipation arises because of the presence of the polymer segments. These results shed light on the diffusive behavior of polymer-coated inorganic nanoparticles in complex and crowded biological environments, such as in the joint.

show abstract

“…The proposed chemical potential is verified further by developing a mass diffusion coefficient using both approaches, the standard chemical potential of mixing and that of dispersion. The behaviour of the diffusion coefficient is also explained in [78] by a meanfield hydrodynamic theory in porous medium. Interestingly, this seems to coincide with the porous-like model we used in our work, which lead finally to expression Eq.…”

Section: Discussionmentioning

confidence: 99%