Diffusion tensor imaging for characterizing white matter changes in multiple sclerosis

Elshafey, Rasha; Hassanien, Omar Ahmed; Khalil, Mohamed M.

doi:10.1016/j.ejrnm.2014.04.006

Cited by 15 publications

(11 citation statements)

References 20 publications

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“…Concerning the spinal cord, the present study agreed with previous DTI studies of the spinal cord in MS patients reported a statistically significant FA difference between the control group and the MS patient group [3,[7][8][9][10][11]. Chen et al [7] stated that the decrease in the FA value of NAWM and the increase in MD value as compared to normal controls indicate the presence of occult damage to the NAWM.…”

Section: Discussionsupporting

confidence: 90%

Diffusion tensor imaging for assessment of normally appearing white matter of the brain and spinal cord in cases of multiple sclerosis: a multi-parametric correlation in view of patient’s clinical status

ElSayed¹,

Eltoukhy

Asaad

et al. 2019

Egypt J Radiol Nucl Med

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Background: Conventional MRI provides important morphologic information regarding the brain and spinal cord involvement by demyelinating plaques. However, it is of almost no value in assessing the normal-appearing white matter which has been proved by multiple pathologic studies to be directly and indirectly involved in the process of multiple sclerosis. Diffusion-weighted imaging and diffusion tensor imaging MRI have been widely used in multiple researches as a better solution for studying the normal-appearing white matter. The purpose of this study was to evaluate the role of diffusion tensor imaging examination of the normal-appearing white matter of the brain and spinal cord in patients with multiple sclerosis and to determine the relationship between diffusion tensor imaging metrics and patient's clinical status. Results: The significant negative correlation found between expanded disability status scale score of secondary progressive MS patients and global (brain and spinal cord) average fractional anisotropy values in normal-appearing white matter and tracts (P = 0.000). Correlation between average apparent diffusion coefficient of corpus callosum tract and expanded disability status scale score revealed a significant positive correlation in RRMS (P = 0.001). While in secondary progressive MS, a significant negative correlation between fractional anisotropy average of the corpus callosum tract and expanded disability status scale score was noted (P = 0.015). Conclusion: There is a strong relationship between diffusion tensor imaging readings and clinical status of patients can be used to understand unexplained deterioration over disease course and also can be used when conventional MRI findings are equivocal. Corpus callosum affection in MS patients is intimately related to clinical status and its assessment should be done whenever possible.

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Section: Discussionsupporting

confidence: 90%

Diffusion tensor imaging for assessment of normally appearing white matter of the brain and spinal cord in cases of multiple sclerosis: a multi-parametric correlation in view of patient’s clinical status

ElSayed¹,

Eltoukhy

Asaad

et al. 2019

Egypt J Radiol Nucl Med

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“…As previously stated, diffusion metrics are associated with WM tract integrity. A decrease in FA reflects the loss of WM microstructural integrity, while an MD increase is associated with edema, axonal, and myelin loss (Elshafey, Hassanien, & Khalil, ). These observations have been previously reported in MS patients (Liu et al, ) and were accordingly observed in the whole‐brain WM of the RRMS group in the present study.…”

Section: Discussionsupporting

confidence: 88%

The retinal ganglion cell layer predicts normal‐appearing white matter tract integrity in multiple sclerosis: A combined diffusion tensor imaging and optical coherence tomography approach

Alves

Batista

d’Almeida

et al. 2018

Human Brain Mapping

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We investigated the relationship between retinal layers and normal-appearing white matter (WM) integrity in the brain of patients with relapsing-remitting multiple sclerosis (MS), using a combined diffusion tensor imaging and high resolution optical coherence tomography approach. Fifty patients and 62 controls were recruited. The patients were divided into two groups according to presence (n = 18) or absence (n = 32) of optic neuritis. Diffusion tensor data were analyzed with a voxel-wise whole brain analysis of diffusion metrics in WM with tract-based spatial statistics. Thickness measurements were obtained for each individual retinal layer. Partial correlation and multivariate regression analyses were performed, assessing the association between individual retinal layers and diffusion metrics across all groups. Region-based analysis was performed, by focusing on tracts associated with the visual system. Receiver operating characteristic (ROC) curves were computed to compare the biomarker potential for the diagnosis of MS, using the thickness of each retinal layer and diffusion metrics. In patients without optic neuritis, both ganglion cell layer (GCL) and inner plexiform layer thickness correlated with the diffusion metrics within and outside the visual system. GCL thickness was a significant predictor of diffusion metrics in the whole WM skeleton, unlike other layers. No association was observed for either controls or patients with a history of optic neuritis. ROC analysis showed that the biomarker potential for the diagnosis of MS based on the GCL was high when compared to other layers. We conclude that GCL integrity is a predictor of whole-brain WM disruption in MS patients without optic neuritis.

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“…Bengtsson et al ( 87 ) reported that auditory-sensorimotor training can increase myelination due to increased neural activity in the fiber tracts during training. The authors reported enhanced Fractional Anisotropy [usually reduced in multiple sclerosis ( 89 , 90 )] in corpus callosum, cortico-spinal, cortico-cortical tracts, and the posterior limb of the internal capsule. These neural structures are of critical importance when considering fine motor performance, bimanual coordination, auditory processing and motor learning ( 91 , 92 ).…”

Section: Discussionmentioning

confidence: 99%

Effects of Rhythmic Auditory Cueing in Gait Rehabilitation for Multiple Sclerosis: A Mini Systematic Review and Meta-Analysis

Ghai

2018

Front. Neurol.

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Rhythmic auditory cueing has been shown to enhance gait performance in several movement disorders. The “entrainment effect” generated by the stimulations can enhance auditory motor coupling and instigate plasticity. However, a consensus as to its influence over gait training among patients with multiple sclerosis is still warranted. A systematic review and meta-analysis was carried out to analyze the effects of rhythmic auditory cueing in studies gait performance in patients with multiple sclerosis. This systematic identification of published literature was performed according to PRISMA guidelines, from inception until Dec 2017, on online databases: Web of science, PEDro, EBSCO, MEDLINE, Cochrane, EMBASE, and PROQUEST. Studies were critically appraised using PEDro scale. Of 602 records, five studies (PEDro score: 5.7 ± 1.3) involving 188 participants (144 females/40 males) met our inclusion criteria. The meta-analysis revealed enhancements in spatiotemporal parameters of gait i.e., velocity (Hedge's g: 0.67), stride length (0.70), and cadence (1.0), and reduction in timed 25 feet walking test (−0.17). Underlying neurophysiological mechanisms, and clinical implications are discussed. This present review bridges the gaps in literature by suggesting application of rhythmic auditory cueing in conventional rehabilitation approaches to enhance gait performance in the multiple sclerosis community.

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Diffusion tensor imaging for characterizing white matter changes in multiple sclerosis

Cited by 15 publications

References 20 publications

Diffusion tensor imaging for assessment of normally appearing white matter of the brain and spinal cord in cases of multiple sclerosis: a multi-parametric correlation in view of patient’s clinical status

Diffusion tensor imaging for assessment of normally appearing white matter of the brain and spinal cord in cases of multiple sclerosis: a multi-parametric correlation in view of patient’s clinical status

The retinal ganglion cell layer predicts normal‐appearing white matter tract integrity in multiple sclerosis: A combined diffusion tensor imaging and optical coherence tomography approach

Effects of Rhythmic Auditory Cueing in Gait Rehabilitation for Multiple Sclerosis: A Mini Systematic Review and Meta-Analysis

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