Difructose anhydride III decreases body fat as a low-energy substitute or by decreasing energy intake in non-ovariectomized and ovariectomized female rats

Abstract

We evaluated the effects of difructose anhydride III (DFAIII) on body weights of ovariectomized rats, which are a good model for obesity by estrogen deficiency-induced overeating. Female rats (10 weeks old) were subjected to ovariectomy or sham operation and then fed with or without a diet containing 3% or 6% DFAIII for 33 days or pair-fed control diet during the same period. Rats fed DFAIII showed significantly decreased food intake, energy intake, body weight gain, body energy accumulation, and fat tissue weight than control group, regardless of ovariectomy. DFAIII may decrease body fat dependent of reduced food/energy intake. Compared with the respective pair feeding groups, rats fed DFAIII showed significantly decreased body energy and fat tissue weight, regardless of ovariectomy, suggesting its potential as a low-energy substitute for high-energy sweeteners. The low energy of DFAIII may contribute to decreased body fat, which may not be dependent on obesity.

Impact of difructose anhydride III, raffinose, and fructooligosaccharides on energy intake, gut hormones, and cecal fermentation in rats fed a high-fat and high-sucrose diet

“…DFA III is produced from inulin, 18) and it promotes intestinal mineral absorption [19][20][21] and shows prebiotic effects. 22,23) Although DFA III lowers cholesterol 24) in isoflavonefed rats and suppresses energy intake in female rats with or without ovariectomy, 25) its effect in dietinduced obesity in animal models has not been demonstrated.…”

Efecto de la ovariectomía prepuberal sobre la función del tejido adiposo blanco abdominal y subcutáneo

“…Así como ocurre con la ovariectomía a edad adulta 175,176 , hemos determinado aquí que la castración prepuberal también es capaz de provocar hiperfagia a partir de los 34 días de vida, en comparación con los animales CTR. El estado nutricional del grupo OVX, hace que no sea muy representativo a la hora de estudiar solamente los efectos de la carencia hormonal sobre el desarrollo y función del TAB, debido a la imposibilidad de determinar efectos independientes entre el aumento del consumo de alimento y la castración.…”