Dig the root of cancer: targeting cancer stem cells therapy

Xu, Haineng; Liu, Tianrun; Xiao, Jing; Mu, Jian

doi:10.24262/jmd.2.2.17003

Cited by 4 publications

(4 citation statements)

References 33 publications

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“…The characteristics of cancer stem cells include multidirectional differentiation potential, self-renewal ability, multiple drug resistance, and the ability to influence tumor development (5). Therefore, there is increasing evidence that cancer stem cells in tumor tissues may contribute to recurrence in many cancers.…”

Section: Discussionmentioning

confidence: 99%

“…The primary causes of mortality in PTC patients include local recurrence and distant metastases. Recent evidence indicates that these events occur due to the presence of a specific population of cancer stem cells (CSCs), which exist within various tumor types (3); these are considered the root cause of tumorigenesis, metastasis and recurrence (4,5). Recently, studies utilizing cancer stem cell markers, CD133, CD44, EpCAM, LGR5 and ALDH1, have confirmed the presence of CSCs in lung, breast, pancreatic and prostate cancers (6)(7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

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Long non-coding RNA BANCR regulates cancer stem cell markers in papillary thyroid cancer via the RAF/MEK/ERK signaling pathway

Wang

Lin

et al. 2018

Oncol Rep

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Thyroid cancer is one of the most common malignant tumors of the endocrine system. Among all thyroid cancers, papillary thyroid carcinoma (PTC) is the most common type. The BRAF-activated non-coding RNA (BANCR) is a 693-bp nucleotide transcript which was first identified in melanoma. However, the role of BANCR in the development of thyroid cancer remains unclear. Therefore, the present study investigated the potential involvement of BANCR in the development of thyroid cancer in vitro using patient tissue samples and a panel of thyroid cancer cell lines, and in vivo using a xenograft mouse model. We observed that BANCR was expressed at a higher level in human thyroid tumor tissues than that noted in the adjacent normal tissues. The expression level of BANCR differed between cultured thyroid cancer cell lines; BANCR expression was lower in the BCPAP cell line than that observed in the CAL-62, WRO and FTC-133 cell lines. Western blot analysis and flow cytometry revealed that overexpression of BANCR in the BCPAP cell line resulted in increased expression of the cancer stem cell markers, LGR5 and EpCAM. Single-clone formation experiments showed that upregulated expression of BANCR in the BCPAP cell line promoted an increase in the number of clones formed. Similarly, in microsphere formation experiments, overexpression of BANCR resulted in increased number and size of microspheres compared with the control cell line. Western blotting experiments showed that BANCR overexpression in BCPAP upregulated the expression of phosphorylated c-Raf, MEK1/2 and ERK1/2. Inhibition of c-Raf via U0126 decreased the expression of LGR5 and EpCAM, as well as phosphorylated levels of c-Raf, MEK1/2 and ERK1/2 in the BCPAP cells, compared to levels in the DMSO controls. In the xenograft mouse model, BANCR overexpression in the thyroid cancer cells significantly increased tumor growth. Taken together, these results suggest that BANCR plays a role in PTC development by regulating the expression of cancer stem cell markers LGR5 and EpCAM via the c-Raf/MEK/ERK signaling pathway. Therefore, BANCR may be used as a novel prognostic marker for PTC.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Long non-coding RNA BANCR regulates cancer stem cell markers in papillary thyroid cancer via the RAF/MEK/ERK signaling pathway

Wang

Lin

et al. 2018

Oncol Rep

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“…Cancer is a severe disease leading to millions of death worldwide 1 . Oral cavity cancer is a malignant tumor with high incidence, which is known for its poor prognosis and high mortality rates because of features such as high invasiveness and metastasis 2 , 3 .…”

Section: Introductionmentioning

confidence: 99%

FoxM1 promotes epithelial–mesenchymal transition, invasion, and migration of tongue squamous cell carcinoma cells through a c-Met/AKT-dependent positive feedback loop

Yang

Wen

et al. 2018

Anti-Cancer Drugs

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“…The patient-derived iPSC can be used to repair or regenerate the tissues which were damaged due to treatment 106,107 . Cancer stem cells (CSCs) are known to attract normal stem cells which is the reason why normal stem cells are being engineered to target CSCs to ensure the high therapeutic efficacy of cancer therapy and also prevent the recurrence of the tumor 108 .…”

Section: From Basic Biology To Clinical Applicationmentioning

confidence: 99%

Untitled

2023

IJPSR

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Stem cell-based therapeutics have considerable potential to treat a variety of illnesses that are now incurable. Because of recent scientific advancements, the area of applied medical research has taken a positive turn, and stem cell-based techniques have moved considerably closer to clinical applications. Since their discovery, stem cells have revolutionized medical research and dramatically altered our understanding of human biology. Understanding of the evolution of the human body and how it fixes itself after harm has been greatly increased. This is why the use of stem cells in human applications has expanded dramatically. This has boosted interest in stem cell therapy. With a genuine interest in long-term quality research into critical problems, some of which are described below, it will be intriguing to deliver therapies based on stem cells to patients with terminal diseases and impairments in order to assist them significantly enhance their quality of life. Stem cell treatments have emerged as a promising and advanced area in scientific study in recent years. This advancement has increased the bar for the treatment of fatal illnesses. This research examines the many kinds of stem cells and their possible therapeutics. This study focuses on the scientific foundations, present scenarios, and clinical applications of stem cells in the treatment of numerous currently incurable diseases, as well as future advances in our health care industry. INTRODUCTION:Stem cells are the cells of the human body that are unspecialized and have the ability to differentiate into many different cell types of an organism. These cells also possess characteristics of self-renewal 1, 2 . There are many potential sources from which different stem cells can be derived. Some of these sources include embryonic stem cells (ESCs), fetal stem cells (FSCs), neural stem cells (NSCs), umbilical cord stem cells (UCSCs), adult stem cells, and mesenchymal stem cells (MSCs).

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Dig the root of cancer: targeting cancer stem cells therapy

Cited by 4 publications

References 33 publications

Long non-coding RNA BANCR regulates cancer stem cell markers in papillary thyroid cancer via the RAF/MEK/ERK signaling pathway

Long non-coding RNA BANCR regulates cancer stem cell markers in papillary thyroid cancer via the RAF/MEK/ERK signaling pathway

FoxM1 promotes epithelial–mesenchymal transition, invasion, and migration of tongue squamous cell carcinoma cells through a c-Met/AKT-dependent positive feedback loop

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