Digestibility Characteristics of Isomaltooligosaccharides in Comparison with Several Saccharides Using the Rat Jejunum Loop Method

Abstract

Isomaltooligosaccharides (IMO) are a mixture of isomaltose, isomaltotriose, panose, isomaltotetraose, etc. IMO and its hydrogenated derivative (IMH) were characterized for their luminal clearance from rat jujunum loops as the indication of their digestibility. They were compared with a disaccharide fraction (IM2) and a higher oligosaccharide fraction (IM3) prepared from IMO, typical digestible saccharides (maltose, maltotriose, and sucrose), and typical nondigestible saccharides (maltitol, raffinose, and fructooligosaccharides (FO)). The clearance rate of IMO was significantly smaller than that of IM2, which was mainly composed of isomaltose (64.3%), and digestible saccharides, and significantly larger than that of nondigestible saccharides. That of IM2 was almost the same as that of sucrose or maltotriose but significantly smaller than that of maltose. That of IM3 tended to be smaller than that of IMO, and larger than that of nondigestible saccharides. That of IMH was significantly smaller than that of IMO and similar to that of maltitol. These results seem to indicate that IMO is slowly digested in the jejunum, that the components having higher degree of polymerization of IMO are less digestible, and that IMH is nondigestible.

Comparison of digestibility and breath hydrogen gas excretion of fructo-oligosaccharide, galactosyl-sucrose, and isomalto-oligosaccharide in healthy human subjects

“…From the results of luminal clearance from rat jejunum loops, Kaneko et al (1995) demonstrate that IMO is slowly digested (Kaneko et al, 1995). However, panose and isomaltotriose, which are the main components of IMO, are readily hydrolyzed in in vitro assay using rat small intestinal enzymes (Oku, 1997).…”

Dietary modulation of the human colonic microbiota: updating the concept of prebiotics

“…Studies carried out by Kaneko et al (1995) using rats demonstrated that IMO was digested slowly in the jejunum and that components with a higher DP were less digestible and that the hydrogenated derivative of IMO was nondigestible. As such, it enters the colon in variable amounts.…”

Prebiotics: Present and future in food science and technology

“…Inulin-type fructans Coppa, Bruni, Zampini, Galeazzi, and Gabrielli (2002), Franck (2002), Roberfroid (2002), Roberfroid (2005) TOS Bouhnik et al (1997, Crittenden and Playne (1996), Vandenplas (2002) Lactulose Ballongue et al (1997), Gibson and Angus (2000) IMO Kaneko et al (1995), Kohmoto et al (1991) Lactosucrose Ohkusa et al (1995), Playne and Crittenden (1996) Xylooligosaccharides Crittenden and Playne (2002), Yamada (1993) SOS Crittenden and Playne (1996), Hayakawa et al (1990), Jaskari (1998) Glucooligosaccharides Chung and Day (2002), Djouzi et al (1995) Carbohydrates Chen et al (2002), Kanauchi (2003), Murphy (2001) The ecological consideration has significance for the safety of prebiotics (Hammes & Hertel, 2002). With regard to their safety evaluation, one has to consider the inherent properties of the prebiotic compound as well as their effects on the microbial flora altogether.…”