Digital Laser Doppler Flowmetry: Device, Signal Processing Technique, and Clinical Testing

Kozlov, Igor; Zherebtsov, Evgeny; Podmasteryev, K. V.; Dunaev, Andrey V.

doi:10.1007/s10527-021-10061-7

Cited by 9 publications

(9 citation statements)

References 9 publications

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“…The rhythmic characteristics of oscillatory processes in the microcirculation system are useful for diagnosis of many diseases related to the changes in microcirculation [34]. The LDF method allows non-invasive assessment of disturbances in the human blood microcirculation system.…”

Section: Discussionmentioning

confidence: 99%

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Post-COVID Syndrome: A Common Neuroimmune Ground?

Ryabkova¹,

Gavrilova²,

Fedotkina³

et al. 2022

Preprint

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A Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating chronic disease of unknown aetiology under growing interest now in view of the increasingly recognized post-COVID syndrome as a new entity with similar clinical presentation. We performed the first cross-sectional study of ME/CFS in community population in Russia and then described and compared some clinical and pathophysiological characteristics of ME/CFS and post-COVID syndrome as neuroimmune disorders. Of the cohort of 76 individuals who suggested themselves suffering from ME/CFS 56 subsequently were confirmed as having CFS/ME according to ≥1 of the 4 most commonly used case definition. Of the cohort of 14 individuals with post-COVID-19 syndrome 14 met diagnostic criteria for ME/CFS. The prevalence of clinically expressed and subclinical anxiety and depression in ME / CFS and post-COVID ME/CFS did not differ significantly from that in healthy individuals. Severity of anxiety / depressive symptoms did not correlate with the severity of fatigue neigther in ME / CFS nor in post-COVID ME/CFS, but the positive correlation was found between the severity of fatigue and 20 other symptoms of ME / CFS related to the domains of “post-exertional exhaustion”, “immune dysfunction”, “sleep disturbances”, "dysfunction of the autonomic nervous system", "neurological sensory / motor disorders" and "pain syndromes". Immunological abnormalities were identified in 12/12 patients with ME / CFS according to the results of laboratory testing. The prevalence of postural orthostatic tachycardia assessed by the active standing test was 37.5% in ME / CFS and 75.0% in post-COVID ME/CFS (the latter was higher than in healthy controls, p = 0.02) There was a more pronounced increase in heart rate starting from the 6th minute of the test in post-COVID ME/CFS compared with the control group. Assessment of the functional characteristics of microcirculation by laser doppler flowmetry revealed obvious and very similar changes in ME/CFS and post-COVID ME/CFS compared to the healthy controls. The identified pattern corresponded to the hyperemic form of microcirculation disorders, usually observed in acute inflammatory processes or in deficiency of systemic vasoconstriction influences.

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Section: Discussionmentioning

confidence: 99%

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Post-COVID Syndrome: A Common Neuroimmune Ground?

Ryabkova¹,

Gavrilova²,

Fedotkina³

et al. 2022

Preprint

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“…Вивчення мікроциркуляторного русла, його будови, розвитку в онтогенезі широко висвітлено у роботах В. І. Козлова, В. В. Купріянова, Ф. Б. Літвіна, О. А Гурової та інших вчених [1][2][3][4][5][6][7]. Дослідження системи мікроциркуляції крові проводиться методом лазерної допплерівської флоуметрії (ЛДФ), що широко використовується у віковій фізіології та клінічних дослідженнях таких вчених: Е. С. Мач, І. П. Аносов, Л. В. Антоновська, І. А. Тихомирова та інші [8][9][10].…”

Section: мелітопольський державний педагогічний університет імені богдана хмельницького українаunclassified

“…Дослідження системи мікроциркуляції крові проводиться методом лазерної допплерівської флоуметрії (ЛДФ), що широко використовується у віковій фізіології та клінічних дослідженнях таких вчених: Е. С. Мач, І. П. Аносов, Л. В. Антоновська, І. А. Тихомирова та інші [8][9][10]. Реактивність тканинного кровотоку організму людини на вплив температур різного діапазону було досліджено В. І. Козловим, Ф. Б. Літвіним, О. А. Гуровою, Т. І. Станішевською [1][2][3][4][5][6][7].…”

Section: мелітопольський державний педагогічний університет імені богдана хмельницького українаunclassified

“…Записи ЛДФ-грам робилися відповідно до методичних рекомендацій: «Методика лазерної допплерівської флоуметрії») [4,8,12].…”

Section: мелітопольський державний педагогічний університет імені богдана хмельницького українаunclassified

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Reactivity of the Blood Microcirculation System in Primary School Children to the Temperature Factor

Stanishevska¹,

Gorna²,

Kopylova³

2021

Ukr. ž. med. bìol. sportu

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The purpose of the study was to investigate the adaptive capacity of the blood microcirculation system in children of primary school age for a functional test with heating. The article deals with the study of the blood microcirculation system in primary school children by laser Doppler flowmetry and the study of the reserve capacity of tissue blood flow in children on a test with increasing temperature factor. Materials and methods. The research was conducted on the basis of the laboratory of physiological research of the Department of Anatomy and Physiology of People and Animals of Bohdan Khmelnytsky Melitopol State Pedagogical University. The surveyed contingent consisted of 80 practically healthy children aged 6 to 9 years old, secondary school students in Melitopol. Based on a comprehensive morphofunctional study, we obtained data on individual-typological features of blood microcirculation in primary school children and the reserve capacity of tissue blood flow using functional tests. It is established that the adaptive features of the blood microcirculation system in boys and girls of early school age are due to different levels of local and central mechanisms of microvessel regulation. Results and discussion. The results obtained during the thermal test indicate different levels of reactivity of the body to increasing the temperature factor and the neurogenic vasoconstrictor effects of the sympathetic nervous system on the vessels of the arteriolar part of the microcirculatory tract. The reaction to the thermal test directly depends on the individual-typological features of blood microcirculation. Conclusion. At a ratio of reaction to thermal influence in children with various types of microcirculation, the maximum increase in tissue perfusion was observed in children with type III of laser Doppler flowgram. This level of microvascular reactivity, as well as the relatively rapid recovery of blood flow after thermal hyperemia is explained by the fact that children with hyperemic type of microcirculation have increased microvascular tone due to neurogenic effects of the sympathetic chain of tissue blood flow regulation. Children with the hypoemic type of microcirculation, on the other hand, have a somewhat reduced sympathetic tone relative to the normoemic type, as a result of which the reserve of capillary blood flow is reduced and the time of blood flow recovery after thermal exposure is prolonged

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“…This method is widely used in the diagnosis of complications of diabetes mellitus [17,18], rheumatic diseases [19], hypertension [20] and a number of other socially important diseases. Over the years, different modifications of the conventional laser Doppler technique had been introduced, including several attempts at developing wearable devices [21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Assessment of Blood Microcirculation Changes after COVID-19 Using Wearable Laser Doppler Flowmetry

et al. 2023

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The present work is focused on the study of changes in microcirculation parameters in patients who have undergone COVID-19 by means of wearable laser Doppler flowmetry (LDF) devices. The microcirculatory system is known to play a key role in the pathogenesis of COVID-19, and its disorders manifest themselves long after the patient has recovered. In the present work, microcirculatory changes were studied in dynamics on one patient for 10 days before his disease and 26 days after his recovery, and data from the group of patients undergoing rehabilitation after COVID-19 were compared with the data from a control group. A system consisting of several wearable laser Doppler flowmetry analysers was used for the studies. The patients were found to have reduced cutaneous perfusion and changes in the amplitude–frequency pattern of the LDF signal. The obtained data confirm that microcirculatory bed dysfunction is present in patients for a long period after the recovery from COVID-19.

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Digital Laser Doppler Flowmetry: Device, Signal Processing Technique, and Clinical Testing

Cited by 9 publications

References 9 publications

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Post-COVID Syndrome: A Common Neuroimmune Ground?

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Post-COVID Syndrome: A Common Neuroimmune Ground?

Reactivity of the Blood Microcirculation System in Primary School Children to the Temperature Factor

Assessment of Blood Microcirculation Changes after COVID-19 Using Wearable Laser Doppler Flowmetry

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