Digital subtraction in Gd-DTPA enhanced imaging of the breast

Flanagan, F.; Murray, John; Gilligan, Paddy; Stack, John D.; Ennis, J. T.

doi:10.1016/s0009-9260(05)83106-x

Cited by 16 publications

(11 citation statements)

References 12 publications

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“…[10][11][12][13][14][15] Further, direct electronic acquisition enables the exploration of novel imaging techniques such as tomosynthesis, 16,17 dual-energy mammography, 18,19 and digital subtraction imaging. 20 In the past, investigators have used different modes of electronic detection technology to gain insight into electronic mammography, commonly referred to as digital mammography. 21 Early evaluations have used image intensifiers and subsequently slot-scanned systems 22,23 with charge-coupled devices ͑CCDs͒ and CCDs with fiberoptic tapers.…”

Section: Introductionmentioning

confidence: 99%

Full breast digital mammography with an amorphous silicon‐based flat panel detector: Physical characteristics of a clinical prototype

et al. 2000

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The physical characteristics of a clinical prototype amorphous silicon-based flat panel imager for full-breast digital mammography have been investigated. The imager employs a thin thallium doped CsI scintillator on an amorphous silicon matrix of detector elements with a pixel pitch of 100 microm. Objective criteria such as modulation transfer function (MTF), noise power spectrum, detective quantum efficiency (DQE), and noise equivalent quanta were employed for this evaluation. The presampling MTF was found to be 0.73, 0.42, and 0.28 at 2, 4, and 5 cycles/mm, respectively. The measured DQE of the current prototype utilizing a 28 kVp, Mo-Mo spectrum beam hardened with 4.5 cm Lucite is approximately 55% at close to zero spatial frequency at an exposure of 32.8 mR, and decreases to approximately 40% at a low exposure of 1.3 mR. Detector element nonuniformity and electronic gain variations were not significant after appropriate calibration and software corrections. The response of the imager was linear and did not exhibit signal saturation under tested exposure conditions.

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Section: Introductionmentioning

confidence: 99%

Full breast digital mammography with an amorphous silicon‐based flat panel detector: Physical characteristics of a clinical prototype

et al. 2000

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“…The rapid enhancement seen in breast carcinomas is thought to be due to increased vascularity and high microvessel permeability in these tumors [17,18]. Several authors have observed sporadic cases with rapid contrast enhancement in axillary lymph nodes with metastases from breast cancer [19,20], and in intramammary lymph nodes with lymphoid hyperplasia [21]. The aim of the present study was to determine the value of dynamic contrast-enhanced MR imaging in revealing axillary lymph node metastases from breast cancer, which to our knowledge has not been evaluated previously.…”

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confidence: 99%

Axillary lymph node metastases in breast cancer: preoperative detection with dynamic contrast-enhanced MRI

et al. 2000

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Metastatic involvement of axillary lymph nodes is one of the most important prognostic variables in breast cancer. The aim of our work was to study the value of dynamic contrast-enhanced MR imaging in revealing axillary lymph node metastases from breast cancer. A total of 65 patients with invasive breast cancer treated with axillary lymph node dissection were preoperatively evaluated by MRI. T1-weighted dynamic contrast-enhanced 3D images were acquired using a coil covering the breast and the axilla. The dynamic contrast enhancement, size, and morphology of the axillary lymph nodes were registered. Histopathological examination revealed axillary lymph node metastases in 24 patients. When using a signal intensity increase in the lymph nodes of >100% during the first postcontrast image as a threshold for malignancy, 57 of 65 patients were correctly classified (sensitivity 83%, specificity 90%, accuracy 88%). These results were not improved when lymph node size and morphology were used as additional criteria. Axillary lymph nodes can be evaluated as a part of an MR-mammography study without substantial increase in examination time, and provide the surgeon with knowledge about the localization of possible metastatic lymph nodes.

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“…The CNB values (6,7,20,59,60) and base-case MR imaging values (12) were obtained from the literature. The remaining two sets of MR imaging values were obtained from a metaanalysis (58) of data from 11 articles from the literature (4,5,8,9,(61)(62)(63)(64)(65)(66)(67) by using the methods of Moses et al (68). The incremental cost-effectiveness ratio for MR imaging ranged from being borderline cost-effective in the base case to being dominated by CNB (with higher projected life expectancy and lower cost); CNB was proved to be the more costeffective test at most estimates of test performance.…”

Section: Sensitivity Analysismentioning

confidence: 99%

Cost-effectiveness of MR Imaging and Core-Needle Biopsy in the Preoperative Work-up of Suspicious Breast Lesions

Hrung¹,

Langlotz²,

Orel³

et al. 1999

Radiology

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Digital subtraction in Gd-DTPA enhanced imaging of the breast

Cited by 16 publications

References 12 publications

Full breast digital mammography with an amorphous silicon‐based flat panel detector: Physical characteristics of a clinical prototype

Full breast digital mammography with an amorphous silicon‐based flat panel detector: Physical characteristics of a clinical prototype

Axillary lymph node metastases in breast cancer: preoperative detection with dynamic contrast-enhanced MRI

Cost-effectiveness of MR Imaging and Core-Needle Biopsy in the Preoperative Work-up of Suspicious Breast Lesions

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