Digital subtraction radiographic analysis of the combination of bioabsorbable membrane and bovine morphogenetic protein pool in human periodontal infrabony defects

Guimarães, Maria do Carmo Machado; Passanezi, Euloir; Sant’Ana, Adriana Campos Passanezi; Grechi, Sebastião Luiz Aguiar; Taba, Mário

doi:10.1590/s1678-77572010000400010

Cited by 8 publications

(5 citation statements)

References 25 publications

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“…Similarly, in narrow defects, the bone filling may result in a small density gain, while in wide defects, larger bone filling contributes to substantial gain in bone/graft density. However, the density gain may not necessarily be the evidence of true regeneration, as some authors observed no correlation between subtraction radiography outcomes and CAL gain [52].…”

Section: Resultsmentioning

confidence: 98%

Treatment of intrabony defects with modified perforated membranes in aggressive periodontitis: subtraction radiography outcomes, prognostic variables, and patient morbidity

et al. 2018

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Objectives The main objectives of this study were (1) to evaluate bone/graft density alterations by digital subtraction radiography; (2) to determine factors associated with favorable clinical and radiographic outcomes, and (3) to report on patient morbidity after guided tissue regeneration (GTR) in aggressive periodontitis (AgP) patients. Materials and methods Adapting a split-mouth design, 30 comparative intrabony defects in 15 patients were randomly treated with xenogenic graft plus modified perforated membranes (MPM, tests) or xenogenic graft plus standard collagen membranes (CM, controls). The time period of observation was 12 months. Results There were significant improvements in clinical and radiographic parameters within each group, without intergroup differences. However, higher PPD reduction for three-wall defects was noted in MPM sites (5.22 versus 3.62 mm; p = 0.033). Moreover, a significant gain in bone/graft density of 4.9% from 6 to 12 months post-operatively was observed in test sites. Multivariate analysis demonstrated that morphology of intrabony defects was a predictor of CAL gain (p = 0.06), while independent prognostic variables effecting changes in bone/graft density were radiographic defect depth (p = 0.025) and radiographic angle (p = 0.033). The majority of patients reported some discomfort, pain, and edema with mild intensity without any significant differences between treatment modalities. Conclusions This study demonstrated enhanced bone/graft density gain after GTR with MPM, which may indicate greater area of new bone formation. Independent variables effecting treatment outcomes were intrabony defect morphology, radiographic defect depth, and radiographic angle. Clinical relevance This study supports the regenerative treatment of intrabony defects in AgP patients and identifies some variables with prognostic value.

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Section: Resultsmentioning

confidence: 98%

Treatment of intrabony defects with modified perforated membranes in aggressive periodontitis: subtraction radiography outcomes, prognostic variables, and patient morbidity

et al. 2018

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“…These materials have been used for many different applications, e.g. to cover buccal gingival areas in Taiwanese dogs 5 or vertical dehiscence bony defects after implantation in patients 14 , for healing of artificial bone defects and buccal recessions in male dogs 22 , to evaluate interproximal infrabony defects in patients 11 , and also to study the reduction of bone resorption in Labrador dogs after insertion of implants 3 .…”

Section: Discussionmentioning

confidence: 99%

Non-cross-linked collagen type I/III materials enhance cell proliferation: in vitro and in vivo evidence

Willershausen¹,

Barbeck²,

BOEHM

et al. 2014

J. Appl. Oral Sci.

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ObjectiveTo analyze Mucograft®(MG), a recently introduced collagen matrix, in vitro and in vivo, and compare it with BioGide®(BG), a well-established collagen membrane, as control. Material and MethodsA detailed analysis of the materials surface and ultra-structure was performed. Cellular growth patterns and proliferation rates of human fibroblasts on MG and BG were analyzed in vitro. In addition, the early tissue reaction of CD-1 mouse to these materials was analyzed by means of histological and histomorphometrical analysis. ResultsMG showed a three-fold higher thickness both in dry and wet conditions, when compared to BG. The spongy surface of BG significantly differed from that of MG. Cells showed a characteristic proliferation pattern on the different materials in vitro. Fibroblasts tended to proliferate on the compact layers of both collagens, with the highest values on the compact side of BG. In vivo, at day three both materials demonstrated good tissue integration, with a mononuclear cell sheet of fibroblasts on all surfaces, however, without penetrating into the materials.ConclusionsThe findings of this study showed that MG and BG facilitate cell proliferation on both of their surfaces in vitro. In vivo, these two materials induce a comparable early tissue reaction, while serving as cell occlusive barriers.

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“…Recently, Guimarães et al performed a split‐mouth study comparing the performance of a pool of bovine BMP, associated or not with collagen membrane, in the treatment of intrabony defects. The study included 15 patients presenting one pair of intrabony defects.…”

Section: Growth/differentiation Factors and Enamel Matrix Derivativementioning

confidence: 99%

Experimental and clinical studies on regenerative periodontal therapy

Sallum

Ribeiro

Ruiz

et al. 2019

Periodontology 2000

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bone substitutes, enamel matrix proteins, guided tissue regeneration, periodontal, regeneration, tissue engineering | INTRODUC TI ONThe purpose of this chapter of Periodontology 2000 is to review the research carried out in Latin America in the field of periodontal regeneration, focusing mainly on studies using preclinical models (animal models) and randomized controlled clinical trials. It has been organized to reflect the information produced by Latin American research groups, which are accompanied by the appropriate references. The specific questions raised by these groups were explored in each subtopic, based on the results. Therefore, a complete review of this topic is not within the scope of this text as other reviews covering regenerative therapies are available in the literature. [1][2][3][4][5][6][7][8]

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Digital subtraction radiographic analysis of the combination of bioabsorbable membrane and bovine morphogenetic protein pool in human periodontal infrabony defects

Cited by 8 publications

References 25 publications

Treatment of intrabony defects with modified perforated membranes in aggressive periodontitis: subtraction radiography outcomes, prognostic variables, and patient morbidity

Treatment of intrabony defects with modified perforated membranes in aggressive periodontitis: subtraction radiography outcomes, prognostic variables, and patient morbidity

Non-cross-linked collagen type I/III materials enhance cell proliferation: in vitro and in vivo evidence

Experimental and clinical studies on regenerative periodontal therapy

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