Dihydropyrimidine analogs of acyclonucleosides. I. Synthesis and antiviral activity of 2′,3′-dihydroxypropyl derivatives of 5-nitro-2,5-and 1,6-dihydropyrimidines

Vishnevskii, S. G.; Пироженко, В. В.; Chentsova, N. P.; Аntonenko, S. V.; Barbasheva, E. V.; Grin, E. V.; Lyul'chuk, M. G.; Sorochinskii, A. E.; Remennikov, G. Ya.; Puik, A. I.; Kukhar, V. P.

doi:10.1007/bf02219410

Cited by 3 publications

(1 citation statement)

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“…Pyrimidines are known to be essential components of naturally occurring nucleic acids. In addition, they form integral part of biologically active synthetic compounds which are used as anti-bacterial, 9 anti-viral agents, 10 anti-tumor agents, [11][12][13][14][15] and as cardiovascular drug. 16 On the other hand, DMSO is a widely used protophilic dipolar aprotic solvent capable of dissolving both hydrophobic and hydrophilic solutes.…”

Section: Introductionmentioning

confidence: 99%

Temperature-Dependant Volumetric and Compressibility Studies of Drug-Surfactant Interactions in Dimethylsulfoxide (DMSO) Solutions

Chauhan¹,

Rana²,

Akash³

et al. 2012

adv sci lett

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In this work we present apparent molar volume, v and apparent molar adiabatic compressibility, values of sodium dodecyl sulphate (SDS) in DMSO and in DMSO solution of 0.25 % w/v 6-methyl-4(2-hydroxy-3-methoxyphenyl)-2-thioxo-1,2,3,4-tetrahydro pyrimidine-5 carboxylic acid ethyl ester (a pyrimidine derivative drug). The study was carried out over a temperature range (20-40 C) covering a wide range of SDS concentration (2-11 mmol dm −3. Being highly sensitive to the extrinsic experimental conditions, a difference observed in the SDS concentration dependence of both v and , values in pure DMSO and in 0.25% w/v DMSO solution of 6-methyl-4(2-hydroxy-3-methoxyphenyl)-2-thioxo-1,2,3,4-tetrahydro pyrimidine-5 carboxylic acid ethyl ester is regarded as being due to the differing extent of SDS-DMSO interactions; the data tend to indicate the existence of relatively strong SDS-drug interactions.

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