Dilute blood clot lysis time and electrophoretic lipoprotein fractions in a population sample of healthy Romanians

Popescu, T.A.; Stef, C; Moraru, Gavril; Cucuianu, M

doi:10.1016/0021-9150(77)90053-3

Cited by 6 publications

(1 citation statement)

References 15 publications

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“…An increase of plasma factor XIII was reported in patients with type Il-b and type IV hyperlipoproteinemia (Cucuianu et al 1973 and. Later on, during an epidemiological study, a delayed dilute blood clot lysis time was observed in subjects with an increased electrophoretic pre P-lipoprotein fraction (Popescu et al 1977). Since addition of factor XIII to the diluted blood was found to cause a prolongation of clot lysis time, while mercuric compounds, which inhibit fibrin stabilizing factors, produce an acceleration of fibrinolysis (Gallimore andShaw 1969, Tyler 1972) we have considered that the association of increased plasma factor XIII levels with delayed dilute blood clot lysis time in subjects with endogenous hypertriglyceridemia might not be merely casual.…”

Section: Introductionmentioning

confidence: 97%

In Vitro Effect of p-Chlormercuribenzoate upon Dilute Blood Clot Lysis Time in Hyperlipemia

Cucuianu¹,

Stef²,

Zdrenghea³

et al. 1979

Thromb Haemost

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SummaryIn comparison to values obtained in normal-weight normolipenic controls, dilute blood clot lysis time was found to be prolonged in resting and exercised patients with endogenous hypertriglyceridemia. Lysis time was also prolonged in overweight subjects with only slightly increased serum lipids but it was not significantly changed in type II-a hyperlipoproteinemia. An obvious acceleration of clot lysis was noted in patients with decompensated cirrhosis of the liver. Inclusion of p-chlormercuribenzoate (PCMB) into the diluted blood clot caused an acceleration of lysis time. This effect was particularly obvious with hypertriglyceridemic blood and minimal with blood obtained from cirrhotic patients. Addition of various amounts of heat-defibrinated plasma to blood from cirrhotic patients caused a proportional prolongation of clot lysis time and this effect was greatly diminished in the presence of PCMB. Similar amounts of serum had a much lesser effect than defibrinated plasma. Inhibition of fibrin cross-linking by PCMB was confirmed by sodium dodecylsulfate polyacrylamide gel electrophoresis.The present data complete previous observations concerning a higher plasma factor XIII activity in type II-b and type IV hyperlipoproteinemia and suggest that an increased crosslinking of fibrin might partially explain the deficient thrombolysis of hypertriglyceridemic patients.

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Section: Introductionmentioning

confidence: 97%

In Vitro Effect of p-Chlormercuribenzoate upon Dilute Blood Clot Lysis Time in Hyperlipemia

Cucuianu¹,

Stef²,

Zdrenghea³

et al. 1979

Thromb Haemost

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Serum zinc and copper in hyperlipoproteinemia

G¹,

Gabor²,

Kovats³

et al. 1985

Biol Trace Elem Res

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Starting from experimental observations demonstrating that a high ratio of zinc to copper led to hypercholesterolemia in rats, serum Zn and Cu levels were measured by atomic absorption spectrophotometry in 65 normolipemic controls and in 100 subjects with various types of hyperlipoproteinemia (HLP). Serum Zn levels did not significantly differ from control values in any type of HLP. However, hyperlipoproteinemic patients with obvious clinical atherosclerosis displayed significantly lower serum-Zn concentration than hyperlipo-proteinemic subjects without clinical symptoms. On the other hand, when compared to control subjects, serum Cu levels were not found to be decreased, but rather increased, in hyperlipoproteinemic patients with or without atherosclerosis. As a result, the Zn∶Cu ratio appeared to be lower than normal in hyperlipoproteinemic patients with cardiovascular disease. It is conceivable that changes of these trace elements should be rather connected to vessel injury and associated disease than to HLP which, at least in humans, is not accompanied by a high Zn∶Cu ratio.

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Similar behaviour of lecithin:cholesterol acyltrans- ferase and pseudocholinesterase in liver disease and hyperlipoproteinemia

Cucuianu¹,

Opincaru²,

Tăpălagă³

1978

Clinica Chimica Acta

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Dilute blood clot lysis time and electrophoretic lipoprotein fractions in a population sample of healthy Romanians

Cited by 6 publications

References 15 publications

In Vitro Effect of p-Chlormercuribenzoate upon Dilute Blood Clot Lysis Time in Hyperlipemia

In Vitro Effect of p-Chlormercuribenzoate upon Dilute Blood Clot Lysis Time in Hyperlipemia

Serum zinc and copper in hyperlipoproteinemia

Similar behaviour of lecithin:cholesterol acyltrans- ferase and pseudocholinesterase in liver disease and hyperlipoproteinemia

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