Dimensionality of Rolled-up Nanomembranes Controls Neural Stem Cell Migration Mechanism

Koch, Britta; Meyer, Anne K.; Helbig, Linda; Harazim, Stefan M.; Storch, Alexander; Sánchez, Samuel; Schmidt, Oliver G.

doi:10.1021/acs.nanolett.5b02099

Cited by 33 publications

(45 citation statements)

References 67 publications

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“…For neuron cells, the microtubular geometry can even guide the growth direction of the axon (panel (ii) of Figure c), and the cells growing inside the microtubes demonstrated increased photoresistance . Recently, Schmidt and co‐workers investigated the interactions between rolled‐up microtube with different mammalian cells, and their influences on cellular events were investigated in detail . It is expected that these 3D structures can be used to gain molecular insights into key cellular events occurring in 3D microenvironments.…”

Section: Biomimetic Nanomembranesmentioning

confidence: 99%

Assembly and Self‐Assembly of Nanomembrane Materials—From 2D to 3D

Huang

Mei

2018

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Nanoscience and nanotechnology offer great opportunities and challenges in both fundamental research and practical applications, which require precise control of building blocks with micro/nanoscale resolution in both individual and mass-production ways. The recent and intensive nanotechnology development gives birth to a new focus on nanomembrane materials, which are defined as structures with thickness limited to about one to several hundred nanometers and with much larger (typically at least two orders of magnitude larger, or even macroscopic scale) lateral dimensions. Nanomembranes can be readily processed in an accurate manner and integrated into functional devices and systems. In this Review, a nanotechnology perspective of nanomembranes is provided, with examples of science and applications in semiconductor, metal, insulator, polymer, and composite materials. Assisted assembly of nanomembranes leads to wrinkled/buckled geometries for flexible electronics and stacked structures for applications in photonics and thermoelectrics. Inspired by kirigami/origami, self-assembled 3D structures are constructed via strain engineering. Many advanced materials have begun to be explored in the format of nanomembranes and extend to biomimetic and 2D materials for various applications. Nanomembranes, as a new type of nanomaterials, allow nanotechnology in a controllable and precise way for practical applications and promise great potential for future nanorelated products.

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Section: Biomimetic Nanomembranesmentioning

confidence: 99%

Assembly and Self‐Assembly of Nanomembrane Materials—From 2D to 3D

Huang

Mei

2018

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“…In recent years, consid erable research has been put into this field, and advanced devices with improved capaci tance density and energy density have been developed. [28,[41][42][43]142,143] Applying the selfrolling technique, scalable onchip EES microdevices can be designed when combining with wellestablished semicon ductor planar processing technologies. [140] Qu et al designed a fibershaped supercapacitor with high energy densities and long life stability based on hollow graphene/conducting polymer fiber electrodes.…”

Section: Rolled-up Nanotechnology For Ultracompact On-chip Ees Microdmentioning

confidence: 99%

Introducing Rolled‐Up Nanotechnology for Advanced Energy Storage Devices

Deng

Liu

et al. 2016

Advanced Energy Materials

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the aim to circumvent the intermittency of these dynamic resources and provide power supply on demand, energy storage systems that can effectively store the elec trical energy are strongly demanded. [5][6][7] Among numerous electrical energy storage (EES) devices available today, lithium batteries, capacitors, and super capacitors are particularly appealing owing to their large capabilities of storing energy with long service lifetime. [8,9] In recent years, with the rapid development of mate rial science and nanotechnology, energy storage devices with enhanced performance have been realized, [2,[6][7][8][9][10] and they have emerged as the dominant power sources for portable electronics in modern society. Despite the advances already achieved, per formance of these EES devices still needs to be further improved in order to meet the higher requirements of future systems, ranging from microelectrochemcial sys tems (MEMS) to electrical transportation systems like electric vehicles.The development of the electrode mate rials is essential for the improvement of high performance EES systems. [11,12] Noticeably, nanomateirals derived from rolledup nanotechnology have attracted world wide interest recently, and remarkable progress has been made when introducing this technology into the design of energy storage devices. [13][14][15][16][17][18][19][20][21][22][23][24][25] In particular, nanostructures prepared by rolledup nanotechnology offer controllable surface area, short charge diffusion distance, and large freedom for volume change during charge/discharge cycles. In this sense, rolledup nano structured materials can be expected to improve the energy den sity, life cycle, and rate capability of lithiumbased batteries. In addition, the high compatibility with lithography and physical vapor deposition techniques makes rolledup nanotechnology suitable for labonachip EES device fabrication as well as other tremendous integrative devices applications. [26][27][28][29][30] In this report, we focus on the recent progress of using rolledup nanostructured materials as electrodes to develop advanced EES devices, including Liion batteries (LIBs) and LiO 2 batteries. In addition, single tube based EES micro devices as diagnostic electrochemical probes for basic mechanistic investigations are summarized. Notable progress of introducing rolledup nanotechnology into the design of scalable and ultra compact electrostatic capacitors with superior performance is also reviewed. Finally, future trends of applying rolledup nanotechnology to other potential applications, such as scalable Energy storage devices, acting as complementing units for renewable energy sources, play a key role in modern society, and they serve as the dominant power supply for most portable electronics. At the heart of the development of next-generation energy storage devices lies the exploration of intrinsic material properties, architectural design and fabrication methods. Rolled-up nanotechnology, a unique method to self-assemble nanomembranes into 3D structure...

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“…However, previous understanding of cell behaviors, including cell migration, directed mitosis, and differential growth is mainly based on studies of cells cultured on flat, 2D commercial culture substrates . In recent years, the results of cell behavior studies in 3D culture scaffolds have revealed several differences from that in 2D substrates, such as neurite outgrowth, neural stem cell migration, and tumor cell division . Therefore, biocompatible 3D culture scaffolds which can more closely mimic the natural complex 3D microenvironment in vivo are urgently needed.…”

Section: Introductionmentioning

confidence: 99%

“…Microtubes, which have very high aspect ratio with variable diameter in nano‐ and micrometer scale, have almost universal applications in areas as diverse as microoptics, resonators, microrobots, microscale energy storage, micromedical devices, and microbiology . Especially in the field of microbiology, microtube array has great potential as a powerful tool to research the biological mechanisms in 3D culture environment because of the dissimilarity between 2D flat surfaces and 3D extracellular environments in which cells routinely operate in vivo .…”

Section: Introductionmentioning

confidence: 99%

“…However, it still remains challenging to determine the pure impact of environment dimensionality on cell behaviors due to the porosity and compliance of hydrogel scaffold. To address this challenge, microtubes have been used to demonstrate how the tubular confinements of 3D scaffolds affect budding yeast growth, neuron cell growth, neural stem cell migration mechanism, human cancer cell division, and differentiation . However, further studies are still urgent to be carried out to assess the contribution of more complex 3D culture scaffolds to the cellular behaviors, for instance, conical tubular environment.…”

Section: Introductionmentioning

confidence: 99%

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Dimension‐Controllable Microtube Arrays by Dynamic Holographic Processing as 3D Yeast Culture Scaffolds for Asymmetrical Growth Regulation

Yang

et al. 2017

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Transparent microtubes can function as unique cell culture scaffolds, because the tubular 3D microenvironment they provide is very similar to the narrow space of capillaries in vivo. However, how to realize the fabrication of microtube-arrays with variable cross-section dynamically remains challenging. Here, a dynamic holographic processing method for producing high aspect ratio (≈20) microtubes with tunable outside diameter (6-16 µm) and inside diameter (1-10 µm) as yeast culture scaffolds is reported. A ring-structure Bessel beam is modulated from a typical Gaussian-distributed femtosecond laser beam by a spatial light modulator. By combining the axial scanning of the focused beam and the dynamic display of holograms, dimension-controllable microtube arrays (straight, conical, and drum-shape) are rapidly produced by two-photon polymerization. The outside and inside diameters, tube heights, and spatial arrangements are readily tuned by loading different computer-generated holograms and changing the processing parameters. The transparent microtube array as a nontrivial tool for capturing and culturing the budding yeasts reveals the significant effect of tube diameter on budding characteristics. In particular, the conical tube with the inside diameter varying from 5 to 10 µm has remarkable asymmetrical regulation on the growth trend of captured yeasts.

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Dimensionality of Rolled-up Nanomembranes Controls Neural Stem Cell Migration Mechanism

Cited by 33 publications

References 67 publications

Assembly and Self‐Assembly of Nanomembrane Materials—From 2D to 3D

Assembly and Self‐Assembly of Nanomembrane Materials—From 2D to 3D

Introducing Rolled‐Up Nanotechnology for Advanced Energy Storage Devices

Dimension‐Controllable Microtube Arrays by Dynamic Holographic Processing as 3D Yeast Culture Scaffolds for Asymmetrical Growth Regulation

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