The COVID-19 pandemic deeply impacted not only human wealth but also all segments of the economy as well as the field of technology. Thus, the purpose of this paper was to analyze the effects that the pandemic crisis and digitization have had on the financial performance of banks in Central and Eastern European Union countries (CEEC) during the 2010–2021 period. In order to capture an overview of the financial performance of the banking systems in the 10 CEECs, we used three variables—ROA, ROE and NPL—as reference indicators. In order to highlight the impact of the COVID-19 pandemic on the performance of banking systems, we used the number of reported cases as a variable, and to highlight the impact of digitization, we used as indicators the number of automated teller machines (ATMs) per 100,000 adults, number of certificates of secure internet servers, number of credit cards, number of debit cards, percentage of individuals using internet banking, and the number of commercial bank branches per 100,000 adults. Thus, the impact of digitization and the pandemic crisis generated by the COVID-19 virus on the performance of the banking systems in the 10 CEECs is outlined through three regression models using the robust regression model. The obtained results show that, as the infection rates with COVID-19 increased, the performance of banks measured by ROE and ROA decreased. Regarding the impact of digitization on performance, we note that an increase in the use of internet banking and the security of bank servers generated positive effects on the performance of banks. The results of the study are useful for banking product development departments, who should consider the important role of digitization in increasing the performance of banking services and thus design new digital products or ways to expand existing ones on a larger scale.