Diminished motor imagery capability in adults with motor impairment: An fMRI mental rotation study

Kashuk, Saman Rassaei; Williams, Jacqueline; Thorpe, Graham; Wilson, Peter H.; Egan, Gary F.

doi:10.1016/j.bbr.2017.06.042

Cited by 34 publications

(31 citation statements)

References 61 publications

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“…Summarising, the neuroimaging results revealed functional abnormalities in the R cerebellar hemisphere, L medial prefrontal hemisphere and R occipital region [51], L superior parietal lobe, bilateral middle frontal gyrus, bilateral occipital lobe/ cuneus and L cerebellar Lobule VI [52]. Structural white matter abnormalities were found in the R CST and L SLF, L internal capsule and R ILF [56] and in the L SLF with a trend for abnormality in the R SLF, with no abnormality in the microstructure of the CST [57].…”

Section: Summary and Critiquementioning

confidence: 89%

“…An fMRI mental rotation study by Kashuk and colleagues [52] aimed to ascertain whether adults with probable DCD (pDCDAs; not formally diagnosed with DCD, but who obtained scores on various DCD tests which indicate impairment), compared to CPs, exhibit a reduced ability when engaging in implicit motor imagery, which involves representing movements from an internal perspective, and whether they would exhibit atypical patterns of neural activation. A total of 11 adult CPs and 12 pDCDAs took part in the study.…”

Section: Fmri Findingsmentioning

confidence: 99%

“…The authors hypothesised that difficulties found in DCD, such as poor surround inhibition, compromised motor Areas of non-typical brain involvement reported in neuroimaging studies of DCDAs vs. CPs displayed on the R and L medial surfaces of the brain, the brain surface viewed from above and the horizontal section of the brain. The numbers in the coloured rectangular shapes denote each neuroimaging study, as follows: 1 = Marien et al [51], 2 = Kashuk et al [52]; 3 = He et al [53], 4 = Hyde et al [54], 5 = Hodgson et al [55], 6 = Williams et al [56] and 7 = Hyde et al [57]. See Table 1 for details; * denotes not a significant result, but a trend (with medium-large effect size) for decreased tract volume of the R SLF; ** denotes significantly reduced LH lateralisation in DCDAs vs. CPs.…”

Section: Tms Findingsmentioning

confidence: 99%

“…Given the heterogeneity of DCD, it is unlikely that one biomarker for this disorder will be sufficient. Therefore, studies that employ more than one neuroimaging technique, for instance, VBM, HARDI (with CSD model) and fMRI with the same sample of participants with DCD, as mentioned in the context of Kashuk et al's [52] study, are urgently needed.…”

Section: Extending the Types Of Imaging Tools Used In Dcd Researchmentioning

confidence: 99%

“…Additionally, after controlling for brain size, patients with increasing X or Y chromosome dosage also tend to have a disproportionally reduced size of cerebellum, pallidum and amygdala [117][118][119]. As discussed above, cerebellar abnormalities have been reported in neuroimaging studies involving DCDAs [51,52] and children with DCD [82,120,121], but also other developmental disorders, such dyslexia [77,78,122] and ADHD [123]. Furthermore, studies on children with DCD have revealed functional abnormalities in the basal ganglia and pallidum [124,125].…”

Section: Integrative Neuroimagingmentioning

confidence: 99%

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Neuroimaging Findings for Developmental Coordination Disorder (DCD) in Adults: Critical Evaluation and Future Directions

Reid¹

2020

Neuroimaging - Neurobiology, Multimodal and Network Applications

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Approximately 75% of those diagnosed with developmental coordination disorder (DCD) exhibit motor problems in adulthood. Neuroimaging studies promise to reveal the endophenotypes of mature brain systems affected by DCD. The aim here was to review these publications. Bibliographic searches identified papers published before June 2019. Neuroimaging results revealed: functional abnormalities in the prefrontal, frontal and occipital regions, superior parietal lobe and cerebellum; structural white matter abnormalities in the corticospinal tract, internal capsule and inferior and superior longitudinal fasciculi; significantly reduced interhemispheric cortical inhibition within the primary motor cortex (hPMC); lack of increased hPMC activity during a motor imagery task and a reduced leftwards brain asymmetry for speech. These results suggest complex endophenotypes for adults with DCD (DCDAs). However, the studies have shortcomings. For instance, all relied upon small and unrepresentative samples. Gender and age were not tested systematically. The effects of many co-occurring disorders were not controlled. Most studies relied on between group comparisons, which, given the heterogeneity of DCD, may obscure the results for underrepresented cases. Overall, the young field of neuroimaging studies of DCDAs reported interesting results; however, there is an urgent need for investigations to address these shortcomings. Future research directions, including cuttingedge neuroimaging techniques and imaging genetics, are discussed. using a skill and chronological age), acquisition and execution of coordinated motor skills. Second, this motor deficit significantly interferes with the activities of everyday life, academic achievements and occupational and recreational activities. Third, DCD symptoms have their onset in early development. Fourth, deficits in motor skills are not better accounted for by intellectual or visual deficits, or neurological impairments, such as degenerative disorder, cerebral palsy, muscular dystrophy, multiple sclerosis or Parkinson's disease, which affect movement.Different prevalence rates of DCD have been reported; however, perhaps the most reliable are the results from a large UK population study of 6990 7-to 8-yearold children [2]. This study revealed a prevalence of 1.7%. An additional 3.2% of children were identified as having 'probable DCD' by using broader cut-off criteria on tests of motor coordination and activities of daily living. Males are more often affected than females, with the male to female ratio ranging from 2:1 to 7:1 [1].Until recently, motor-coordination difficulties in childhood were thought to be typically outgrown in adulthood. However, it is estimated that approximately 75% of those diagnosed with DCD will continue to exhibit motor problems into adulthood [3,4]. Indeed, studies on DCDAs [5-18] demonstrate that they perform significantly worse than control participants (CPs) on various motor tasks. If one pauses for a moment and considers that the only way humans can affect the wo...

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Section: Summary and Critiquementioning

confidence: 89%

Section: Fmri Findingsmentioning

confidence: 99%