Diminished perception of light as a symptom of depression: Further studies

Friberg, Thomas R.; Bremer, R.W.; Dickinsen, Miriam

doi:10.1016/j.jad.2007.10.021

Cited by 10 publications

(7 citation statements)

References 18 publications

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“…17 In 2008, Friberg and colleagues confirmed these findings in a cross-sectional study of depressed and non-depressed patients. 18 Of 213 subjects in the Age-Related Eye Disease Study, depressed patients were 4.5-times more likely to report diminished perception of ambient light versus non-depressed patients (p50.0001). However, the mechanism linking depression and diminished perception remains unknown.…”

Section: Discussionmentioning

confidence: 98%

Suicide and Visual Loss: A Case Report Reflecting the Need for Recognition and Management in Ophthalmological Settings

Johnson

Rovner²,

Haller

2014

Seminars in Ophthalmology

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In the United States, 5.5 million people over the age of 40 meet criteria for visual impairment (VI). They often suffer significant psychosocial and health consequences, including reduced quality of life and depression, which can be persistent and difficult to treat. Additionally, VI may increase the risk of suicide. We report a case of a patient with age-related macular degeneration (ARMD) and suicidal ideation. While this link is reasonable, there are no prior cases of suicidality among patients with ARMD. Moreover, the literature is silent regarding proper approaches to diagnosing and managing suicidality among patients with VI, especially ARMD.

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Section: Discussionmentioning

confidence: 98%

Suicide and Visual Loss: A Case Report Reflecting the Need for Recognition and Management in Ophthalmological Settings

Johnson

Rovner²,

Haller

2014

Seminars in Ophthalmology

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“…Indeed, low ambient illumination levels have been found to be associated with negative mood in SAD patients [8] and in general population [9,10]. It has also been reported that diminished perception of ambient light is strongly associated with the degree of depressive symptoms, further supporting the link between light intensity and mood [11,12]. However, the brain mechanisms underlying light intensity-dependent changes in affective state remain unclear.…”

Section: Introductionmentioning

confidence: 99%

Decreased daytime illumination leads to anxiety-like behaviors and HPA axis dysregulation in the diurnal grass rat (Arvicanthis niloticus)

Ikeno

Deats

Soler

et al. 2016

Behavioural Brain Research

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The impact of ambient light on mood and anxiety is best exemplified in seasonal affective disorder, in which patients experience depression and anxiety in winter when there is less light in the environment. However, the brain mechanisms underlying light-dependent changes in affective state remain unclear. Our previous work revealed increased depression-like behaviors in the diurnal Nile grass rat (Arvicanthis niloticus) housed in a dim light-dark (dim-LD) cycle as compared to the controls housed in a bright light-dark (bright-LD) condition. As depression is often comorbid with anxiety and is associated with dysregulation of the body's stress response system, the present study examined the anxiety-like behaviors as well as indicators of the hypothalamic-pituitary-adrenal (HPA) axis functioning in the grass rats. Animals housed in dim-LD showed increased anxiety-like behaviors compared to bright-LD controls, as revealed by fewer entries and less time spent at the center in the open field test and more marbles buried during the marble-burying test. Following the marble-burying test, dim-LD animals showed higher plasma corticosterone (CORT) levels and hippocampal Fos expression. Although the daily CORT rhythm was comparable between bright-LD and dim-LD groups, the day/night variation of corticotropin-releasing hormone mRNA expression in the paraventricular nucleus was diminished in dim-LD animals. In addition, glucocorticoid receptor and mineralocorticoid receptor mRNA expression were higher in the hippocampus of dim-LD animals. The results suggest that in diurnal species, reduced daytime illumination can lead to increased anxiety-like behaviors and altered HPA axis functioning, providing insights into the link between decreased environmental illumination and negative emotion.

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“…We observed an elevated change in the second amplitude but no changes in the first amplitude in MDD patients compared to healthy controls, thus reflecting abnormal cortical visual processing in MDD. Indeed, many lines of studies have reported that MDD is often associated with the subjective experience of altered visual perception, such as photophobia, perceived dimness and reduced visual contrast discrimination (49)(50)(51). Moreover, the impairment in visual perception was found to be directly related to the psychopathological symptoms of MDD (4,8).…”

Section: Discussionmentioning

confidence: 99%

Altered Visual Cortical Excitability Is Associated With Psychopathological Symptoms in Major Depressive Disorder

Shen

et al. 2022

Front. Psychiatry

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Previous studies suggest that in people with major depressive disorder (MDD), there exists a perturbation of the normal balance between the excitatory and inhibitory neurotransmitter systems in the visual cortex, indicating the possibility of altered visual cortical excitability. However, investigations into the neural activities of the visual cortex in MDD patients yielded inconsistent findings. The present study aimed to evaluate the visual cortical excitability utilizing a paired-pulse stimulation paradigm in patients with MDD and to access the paired-pulse behavior of recording visual evoked potentials (VEPs) as a marker of MDD. We analyzed the amplitudes of VEPs and paired-pulse suppression (PPS) at four different stimulus onset asynchronies (SOAs) spanning 93 ms to 133 ms. Further, the relationship between PPS and the symptom severity of depression was investigated using Spearman's correlation. We found that, whereas the first VEP amplitude remained unchanged, the second VEP amplitude was significantly higher in the MDD group compared to the healthy controls. As a result, the amplitude ratio (second VEP amplitude/first VEP amplitude) increased, indicating reduced PPS and thus increased excitability in the visual cortex. Moreover, we found the amplitude ratios had a significantly positive correlation with the symptom severity of depression in MDD, indicating a clinically useful biomarker for MDD. Our findings provide new insights into the changes in the excitation-inhibition balance of visual cortex in MDD, which could pave the way for specific clinical interventions.

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Diminished perception of light as a symptom of depression: Further studies

Cited by 10 publications

References 18 publications

Suicide and Visual Loss: A Case Report Reflecting the Need for Recognition and Management in Ophthalmological Settings

Suicide and Visual Loss: A Case Report Reflecting the Need for Recognition and Management in Ophthalmological Settings

Decreased daytime illumination leads to anxiety-like behaviors and HPA axis dysregulation in the diurnal grass rat (Arvicanthis niloticus)

Altered Visual Cortical Excitability Is Associated With Psychopathological Symptoms in Major Depressive Disorder

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