Diosmetin alleviated cerebral ischemia/reperfusion injuryin vivoandin vitroby inhibiting oxidative stressviathe SIRT1/Nrf2 signaling pathway

Mei, Zhigang; Du, Lipeng; Liu, Xiaolu; Chen, Xiangyu; Tian, Huan; Deng, Yuewen; Zhang, Wenli

doi:10.1039/d1fo02579a

Cited by 47 publications

(28 citation statements)

References 41 publications

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“…These data strongly suggest that injury of testicular spermatogenesis after testicular ischemia-reperfusion is due to overproduction of reactive oxygen species. Previous studies have demonstrated that treatment with reactive oxygen species scavengers can reduce ischemia-reperfusion injury in the liver, kidney, heart, brain, and so on [ 42 – 45 ].…”

Section: Discussionmentioning

confidence: 99%

Salidroside Exerts Beneficial Effect on Testicular Ischemia-Reperfusion Injury in Rats

Wei

Huang

Qin

2022

Oxidative Medicine and Cellular Longevity

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Testicular torsion-detorsion results in testicular ischemia-reperfusion injury, which is associated with overgeneration of reactive oxygen species. Salidroside, a major bioactive ingredient extracted from Rhodiola rosea, has strong antioxidant activity. The purpose of this study was to examine the effect of salidroside on testicular ischemia-reperfusion injury. Sixty rats were randomly separated into 3 experimental groups: group A = sham-operated control; group B = testicular ischemia-reperfusion; and group C = testicular ischemia-reperfusion treated with salidroside. The rats in the sham-operated control group received all surgical procedures except testicular torsion-detorsion. The testicular ischemia-reperfusion group underwent 2 hours of left testicular torsion followed by detorsion. The rats in the salidroside-treated group received the same surgical procedure as in testicular ischemia-reperfusion group, but salidroside was injected intraperitoneally at reperfusion. Testicular malondialdehyde content (a reliable index of reactive oxygen species) and protein expression of superoxide dismutase and catalase which are primary antioxidant enzymes in testes were measured at 4 hours after reperfusion. Testicular spermatogenesis was evaluated at 3 months after reperfusion. The malondialdehyde content increased significantly, while superoxide dismutase and catalase protein expression and testicular spermatogenesis reduced significantly in ipsilateral testes of testicular ischemia-reperfusion group, as compared with sham-operated control group. Therapy with salidroside significantly reduced malondialdehyde content and significantly enhanced superoxide dismutase and catalase protein expression and spermatogenesis in ipsilateral testes, as compared with testicular ischemia-reperfusion group. The present findings indicate that treatment with salidroside ameliorates testicular ischemia-reperfusion injury by reducing reactive oxygen species level by upregulating superoxide dismutase and catalase protein expression.

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Section: Discussionmentioning

confidence: 99%

Salidroside Exerts Beneficial Effect on Testicular Ischemia-Reperfusion Injury in Rats

Wei

Huang

Qin

2022

Oxidative Medicine and Cellular Longevity

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“…It was reported that SIRT1 regulated mitochondrial function and antioxidant defenses through activation of transcriptional coactivator PPAR-γ co-activator1α (PGC-1α) and activities and the anti-oxidant enzyme SOD after brain ischemic damage in rats subjected to transient middle cerebral artery occlusion (tMCAO), a classic FCI animal model ( Li et al, 2021 ). SIRT1 could inhibit oxidative stress in the tMCAO rats by activation of Nrf2, NQO1, and HO-1, which are important factors mediating oxidative stress response ( Mei et al, 2022 ). Besides, the SIRT1/FOXO1 pathway was also reported to be activated by SIRT1 to alleviate excess oxidative injury.…”

Section: Role Of Silent Information Regulator 1 In Cerebral Ischemia-...mentioning

confidence: 99%

A novel link between silent information regulator 1 and autophagy in cerebral ischemia-reperfusion

et al. 2022

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Cerebral ischemia is one of the leading causes of death and disability worldwide. Although revascularization via reperfusion combined with advanced anticoagulant therapy is currently a gold standard treatment for patients, the reperfusion itself also results in a serious dysfunction termed cerebral ischemia-reperfusion (I/R) injury. Silent information regulator 1 (sirtuin 1, SIRT1), is a classic NAD+-dependent deacetylase, which has been proposed as an important mediator in the alleviation of cerebral ischemia through modulating multiple physiological processes, including apoptosis, inflammation, DNA repair, oxidative stress, and autophagy. Recent growing evidence suggests that SIRT1-mediated autophagy plays a key role in the pathophysiological process of cerebral I/R injury. SIRT1 could both activate and inhibit the autophagy process by mediating different autophagy pathways, such as the SIRT1-FOXOs pathway, SIRT1-AMPK pathway, and SIRT1-p53 pathway. However, the autophagic roles of SIRT1 in cerebral I/R injury have not been systematically summarized. Here, in this review, we will first introduce the molecular mechanisms and effects of SIRT1 in cerebral ischemia and I/R injury. Next, we will discuss the involvement of autophagy in the pathogenesis of cerebral I/R injury. Finally, we will summarize the latest advances in the interaction between SIRT1 and autophagy in cerebral I/R injury. A good understanding of these relationships would serve to consolidate a framework of mechanisms underlying SIRT1’s neuroprotective effects and provides evidence for the development of drugs targeting SIRT1.

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“…In addition, our results also found that inhibiting SIRT1 activation could result in ferroptosis in dNCR mice. SIRT1 plays an important role in neurodegenerative diseases and cognitive deficits via regulating the levels of Nrf2 and HO-1 [1,[73][74][75][76]. The activation of SIRT1 targeting Nrf2/HO-1 pathway activation can alleviate central nervous system inflammation-induced cognitive deficits [73].…”

Section: Discussionmentioning

confidence: 99%

Mesenchymal Stem Cell-Derived Exosomes Ameliorate Delayed Neurocognitive Recovery in Aged Mice by Inhibiting Hippocampus Ferroptosis via Activating SIRT1/Nrf2/HO-1 Signaling Pathway

Liu

Huang

Zhang

et al. 2022

Oxidative Medicine and Cellular Longevity

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Delayed neurocognitive recovery (dNCR) is a prevalent perioperative neurological complication in older patients and has common characteristics such as acute cognitive dysfunction, impaired memory, and inattention. Mesenchymal stem cell-derived exosomes (MSCs-Exo) are enclosed by a lipid bilayer contain proteins, DNA, miRNA, and other components, which are important mediators of intercellular communication. It has been reported that exosomes could play an important role in the treatment of neurodegenerative diseases, nerve injury, and other neurological diseases. In this study, we examined the effects of MSCs-Exo on dNCR aged mice after exploratory laparotomy and evaluated their potential regulatory mechanisms. We found that MSCs-Exo treatment ameliorated cognitive impairment in dNCR aged mice. MSCs-Exo inhibit hippocampus ferroptosis and increase the expression of silent information regulator 1 (SIRT1), factor nuclear factor-erythroid 2-related factor 2 (Nrf2), and heme oxygenase-1 (HO-1) in dNCR aged mice. Interestingly, the above effects of MSCs-Exo on dNCR aged mice were abolished by SIRT1 selective inhibitor EX-527. In conclusion, these findings indicated that MSCs-Exo can ameliorate cognitive impairment by inhibiting hippocampus ferroptosis in dNCR aged mice via activating SIRT1/Nrf2/HO-1 signaling pathway, providing a potential avenue for the treatment of dNCR.

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Diosmetin alleviated cerebral ischemia/reperfusion injuryin vivoandin vitroby inhibiting oxidative stressviathe SIRT1/Nrf2 signaling pathway

Abstract: Oxidative stress is known to play a pivotal role in the pathogenesis of cerebral ischemia reperfusion (I/R) injury. Accumulating studies have revealed that diosmetin (Dios) could protect against oxidative stress...

Cited by 47 publications

References 41 publications

Salidroside Exerts Beneficial Effect on Testicular Ischemia-Reperfusion Injury in Rats

Salidroside Exerts Beneficial Effect on Testicular Ischemia-Reperfusion Injury in Rats

A novel link between silent information regulator 1 and autophagy in cerebral ischemia-reperfusion

Mesenchymal Stem Cell-Derived Exosomes Ameliorate Delayed Neurocognitive Recovery in Aged Mice by Inhibiting Hippocampus Ferroptosis via Activating SIRT1/Nrf2/HO-1 Signaling Pathway

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