Dioxins and cytogenetic status of villagers after 40 years of agent Orange application in Vietnam

Сычева, Л. П.; Umnova, N V; Коваленко, М. А.; Vs, Zhurkov; Shelepchikov, A. A.; Roumak, Vladimir S.

doi:10.1016/j.chemosphere.2015.10.009

Cited by 13 publications

(3 citation statements)

References 17 publications

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“…It has been established that chromatin shrinkage followed by disruption of the nuclear membrane may result in cytotoxicity (21). Some authors have postulated that chronic exposure to genotoxins induced an increase in cell death in buccal epithelium of humans (19,20). Our results are fully in agreement with these findings.…”

Section: Discussionsupporting

confidence: 92%

“…On the other hand, no induction of micronucleated cells was observed in buccal epithelia in people exposed to wood dust (19). Similarly, residents in Vietman did not show remarkable differences for micronucleus frequency in buccal mucosa cells after 40 years of dioxin exposure (20). It seems that chronic exposure to known genotoxins modulates the cytogenetic status of exposed groups.…”

Section: Discussionmentioning

confidence: 90%

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Cytogenetic Biomonitoring in Buccal Mucosal Cells from Municipal Solid Waste Collectors

Andrade

Santos

Cury

et al. 2017

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Waste collectors collect, transport, and process the garbage produced by people living in the city. Nowadays, this activity requires special attention due to the environmental impact of garbage and its potential consequences on human health. The aim of this study was to evaluate potential cytotoxic and mutagenic effects of garbage collection on waste collectors. For this purpose, a total of 47 male waste collectors aged from 24 to 53 years were included in the experimental group. A total of 30 men matched by age were used as the control group. Cytotoxicity and mutagenicity were analyzed by micronucleus test in buccal mucosaI cells. No statistically significant difference (p>0.05) in the frequency of micronuclei was detected in the waste collectors when compared to controls. Nevertheless, higher frequencies of karyolysis and pyknosis (p<0.05) were detected in buccal mucosaI cells from waste collectors when compared to matched controls. Taken together, our results indicate that waste collectors comprise an at-risk group as a result of increased cytotoxicity apparent from buccal mucosa cells.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 90%

Cytogenetic Biomonitoring in Buccal Mucosal Cells from Municipal Solid Waste Collectors

Andrade

Santos

Cury

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Some authors have postulated that continuous exposure to genotoxic agents induces chromatin shrinkage followed by disruption of the nuclear membrane may result in cytotoxicity (24). In fact, it has been postulated that chronic exposure to genotoxins induced an increase in cell death in buccal epithelium of humans (25). However, our results did not find any positive results closely related to cytotoxic parameters induced by continuous exposure to rubbish as an indicative of cellular death.…”

Section: Discussioncontrasting

confidence: 91%

Genomic Instability in Buccal Mucosal Cells of Municipal Street Sweepers as Evaluated by Micronucleus Test

Silva

Andrade

Cláudio

et al. 2018

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The content of dioxins and furans in soils, bottom sediments of water bodies, and tissues of small mammals near the landfill site with municipal solid wastes (Moscow, Russia)

Roumak

Levenkova

Umnova

et al. 2018

Environ Sci Pollut Res

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For the first time, the levels of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) were characterized in the tissues of wild small mammals living in contaminated sites near a municipal solid waste landfill (Moscow, Russia). The Ural field mice Sylvaemus uralensis, the bank voles Clethrionomys glareolus, and the common shrews Sorex araneus were trapped at 1- and 5-km distances from the landfield "Salariyevo." High-resolution chromatography-mass spectrometry was used to measure the levels of 17 PCDD/Fs congeners in the animal organisms and natural objects (soils, bottom sediments). The values of the total toxic equivalencies (WHO-TEQ) for animals were many times higher than those for soils and bottom sediments. The octo-substituted congeners dominated in the samples from the habitat, whereas the highly toxic 2,3,7,8-substituted ones - in the mammalian tissues. The levels of WHO-TEQ were comparable in the soil samples collected at 1- and 5-km distances from the dump body. The levels of WHO-TEQ in tissues of mammals caught 1 km from the dump were much higher than those of the distant territory inhabitants. The maximum WHO-TEQ levels were found in the shrews, and this has been considered in terms of nutrition characteristics. The data obtained will be used to assess the risks of chronic exposure to low doses of PCDD/Fs contaminating the environment near landfills.

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Dioxins and cytogenetic status of villagers after 40 years of agent Orange application in Vietnam

Cited by 13 publications

References 17 publications

Cytogenetic Biomonitoring in Buccal Mucosal Cells from Municipal Solid Waste Collectors

Cytogenetic Biomonitoring in Buccal Mucosal Cells from Municipal Solid Waste Collectors

Genomic Instability in Buccal Mucosal Cells of Municipal Street Sweepers as Evaluated by Micronucleus Test

The content of dioxins and furans in soils, bottom sediments of water bodies, and tissues of small mammals near the landfill site with municipal solid wastes (Moscow, Russia)

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