Diphenylether and Macrotriolides Occurring in a Fungal Isolate from the Antarctic Lichen<i>Neuropogon</i>

Иванова, В.; Kolarova, Mariana; Алексиева, K.; Gräefe, Udo; Schlegel, Brigitte

doi:10.1080/10826060601039436

Cited by 15 publications

(10 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…S15†): δ = 21.1, 22.3, 102.7, 104.0, 111.0, 111.4, 111.4, 112.3, 140.5, 141.7, 156.0, 158.6, 160.0, 161.9, 171.8. 1 H and 13 C NMR data (DMSO- d 6 ), were similar with the published data, but there were discrepancies of as much as 0.25 ppm for 1 H NMR and 4.8 ppm for 13 C NMR 35. We performed additional NMR experiments (DEPT, HMQC, HMBC, COSY), which corroborated our assignment of 5 as 2-hydroxy-4-(3-hydroxy-5-methylphenoxy)-6-methylbenzoic acid.…”

Section: Methodssupporting

confidence: 84%

Molecular genetic analysis of the orsellinic acid/F9775 genecluster of Aspergillus nidulans

et al. 2010

View full text Add to dashboard Cite

F-9775A and F-9775B are cathepsin K inhibitors that arise from a chromatin remodelling deletant strain of Aspergillus nidulans. A polyketide synthase gene has been determined to be responsible for their formation and for the simpler, archetypical polyketide orsellinic acid. We have discovered simple culture conditions that result in the production of the three compounds, and this facilitates analysis of the genes responsible for their synthesis. We have now analysed the F9775/orsellinic acid gene cluster using a set of targeted deletions. We find that the polyketide synthase alone is required for orsellinic acid biosynthesis and only two additional genes in the cluster are required for F9775 A and B synthesis. Our deletions also yielded the bioactive metabolites gerfelin and diorcinol.

show abstract

Section: Methodssupporting

confidence: 84%

Molecular genetic analysis of the orsellinic acid/F9775 genecluster of Aspergillus nidulans

et al. 2010

View full text Add to dashboard Cite

show abstract

“…Several species of lichens have been used for various remedies in folk medicine since ancient time and variety of biologically active lichen metabolites, including antimycobacterial, antiviral, antioxidant and antiherbivore properties, have been described [50,51]. Antarctic lichens may have evolved unique secondary metabolites to help in surviving the extreme environment in which they live [52,53,54]. …”

Section: Lichenmentioning

confidence: 99%

Secondary Metabolites from Polar Organisms

Tian

Zhao

2017

Marine Drugs

View full text Add to dashboard Cite

Polar organisms have been found to develop unique defences against the extreme environment environment, leading to the biosynthesis of novel molecules with diverse bioactivities. This review covers the 219 novel natural products described since 2001, from the Arctic and the Antarctic microoganisms, lichen, moss and marine faunas. The structures of the new compounds and details of the source organism, along with any relevant biological activities are presented. Where reported, synthetic and biosynthetic studies on the polar metabolites have also been included.

show abstract

“…Furthermore, the marker at m / z 273.1 (calculated for C 15 H 13 O 5 , [M − H] − ) connecting diorcinol and another targeted lead at m / z 377.1 possessed fragmentation losses similar to those of diorcinol, revealing that they shared a common structural core. This lead which differs a carboxyl group from diorcinol was presumed as 4‐carboxydiorcinol ( 5 ), another diphenyl ether, which has been previously reported as a product of Hypocera citrina and Aspergillus fumigatus (Ivanova et al ., ). The co‐culture induction of 4‐carboxydiorcinol was still visible as its production was enhanced by a factor up to 8 compared with the monoculture ( Supporting information Table S1).…”

Section: Resultsmentioning

confidence: 97%

Synthetic multispecies microbial communities reveals shifts in secondary metabolism and facilitates cryptic natural product discovery

Shi

Pan

Wang

et al. 2017

Environmental Microbiology

View full text Add to dashboard Cite

Chemically mediated interactions have been hypothesized to be essential for ecosystem functioning as co-occurring organisms can influence the performance of each other by metabolic means. Here, we present a co-culture device that allows co-culturing of microorganisms that are physically separated but can exchange chemical signals and metabolites. This setup was adopted to perform investigations on the secondary metabolisms of both a fungal-bacterial community and an actinomycetic-actinomycetic community. This study employed a metabolomics approach integrating LC-MS profiling, multivariate data analysis and molecular networking techniques. LC-MS measurements revealed a pronounced influence of such chemical communication on the metabolic profiles of synthetic co-culture communities with a group of molecules being induced or upregulated in co-cultures. A novel antibiotic exhibiting antibiotic properties against Klebsiella pneumoniae was unveiled in the fungal-bacterial community. Besides, a further survey of the fungal-bacterial cross-talk indicated that the production of co-culture-induced diphenyl ethers by fungi might result from the fungal response against the secretion of surfactins by bacteria in the cross-talk. This study demonstrated that the presented co-culture device and the metabolomic routine would facilitate the investigation on chemically mediated interactions in nature as well as cryptic natural products discovery.

show abstract

Diphenylether and Macrotriolides Occurring in a Fungal Isolate from the Antarctic LichenNeuropogon

Cited by 15 publications

References 3 publications

Molecular genetic analysis of the orsellinic acid/F9775 genecluster of Aspergillus nidulans

Molecular genetic analysis of the orsellinic acid/F9775 genecluster of Aspergillus nidulans

Secondary Metabolites from Polar Organisms

Synthetic multispecies microbial communities reveals shifts in secondary metabolism and facilitates cryptic natural product discovery

Contact Info

Product

Resources

About