Direct and indirect associations between dietary magnesium intake and breast cancer risk

Huang, Wuqing; Long, Weiqing; Mo, Xiong-Fei; Zhang, Naiqi; Luo, Hong; Lin, Fang‐Yue; Huang, Jing; Zhang, Caixia

doi:10.1038/s41598-019-42282-y

Cited by 29 publications

(19 citation statements)

References 62 publications

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“…Although this area of work is relatively new there is an increasing interest in the possible association between Mg status and cancer risk. The recent case-control study of Huang et al [ 60 ] explored the effect of dietary Mg intake on breast cancer risk directly and indirectly via the effect of Mg on the inflammatory markers C-reactive protein (CRP) and interleukin-6 (IL-6). Multivariable logistic regression was used to assess the odds ratio (OR) and 95% confidence interval (95% CI), together with path analysis to explore mediating effects.…”

Section: Magnesium In Human Nutritionmentioning

confidence: 99%

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The Contribution of Dietary Magnesium in Farm Animals and Human Nutrition

et al. 2021

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Magnesium (Mg) is a mineral that plays an essential role as cofactor of more than 300 enzymes. Mg in farm animals’ and human nutrition is recommended to avoid Mg deficiency, ensure adequate growth and health maintenance. Mg supplementation above the estimated minimum requirements is the best practice to improve farm animals’ performances (fertility and yield) and food products’ quality, since the performance of farm animals has grown in recent decades. Mg supplementation in pigs increases meat quality and sows’ fertility; in poultry, it helps to avoid deficiency-related health conditions and to improve meat quality and egg production by laying hens; in dairy cows, it serves to avoid grass tetany and milk fever, two conditions related to hypomagnesaemia, and to support their growth. Thus, Mg supplementation increases food products’ quality and prevents Mg deficiency in farm animals, ensuring an adequate Mg content in animal-source food. These latter are excellent Mg sources in human diets. Sub-optimal Mg intake by humans has several implications in bone development, muscle function, and health maintenance. This review summarizes the main knowledge about Mg in farm animals and in human nutrition.

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Section: Magnesium In Human Nutritionmentioning

confidence: 99%

“… Dose-response association between Mg intake and risk of breast cancer in Chinese women. Derived from [ 60 ]. …”

Section: Figurementioning

confidence: 99%

The Contribution of Dietary Magnesium in Farm Animals and Human Nutrition

et al. 2021

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“…The available data indicate a double and opposite effect of the availability of Mg in the oncology field. In fact, on the one hand, a high content of Mg in the diet seems to be associated with a lower incidence of gastric, colon and breast cancers 4 – 6 . On the other hand, however, various data have shown how the availability of Mg by cancerous tissues could be involved in the development and/or growth of tumors 7 – 9 .…”

Section: Introductionmentioning

confidence: 99%

Low serum magnesium concentration is associated with the presence of viable hepatocellular carcinoma tissue in cirrhotic patients

Parisse

Ferri

Persichetti

et al. 2021

Sci Rep

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This study aimed to ascertain, for the first time, whether serum magnesium (Mg) concentration is affected by the presence of hepatocellular carcinoma (HCC). We retrospectively enrolled consecutive cirrhotic patients with a diagnosis of HCC (n = 130) or without subsequent evidence of HCC during surveillance (n = 161). Serum levels of Mg were significantly (P < 0.001) lower in patients with HCC than in those without (median [interquartile range]: 1.80 [1.62–1.90] mg/dl vs. 1.90 [1.72–2.08] mg/dl). On multivariate logistic regression, low serum Mg was associated with the presence of HCC (OR 0.047, 95% CI 0.015–0.164; P < 0.0001), independently from factors that can influence magnesaemia and HCC development. In a subset of 94 patients with HCC, a linear mixed effects model adjusted for confounders showed that serum Mg at diagnosis of HCC was lower than before diagnosis of the tumor (β = 0.117, 95% CI 0.039–0.194, P = 0.0035) and compared to after locoregional treatment of HCC (β = 0.079, 95% CI 0.010–0.149, P = 0.0259), with two thirds of patients experiencing these changes of serum Mg over time. We hypothesize that most HCCs, like other cancers, may be avid for Mg and behave like a Mg trap, disturbing the body’s Mg balance and resulting in lowering of serum Mg levels.

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“…Some studies have focused on the effect of dietary magnesium on breast cancer prognosis, suggesting that higher dietary intake is inversely associated with mortality among breast cancer patients [ 336 ]. The effect of magnesium intake on breast cancer risk has been explored, both directly and indirectly via its effect on inflammatory markers C-reactive protein and interleukin-6 [ 337 ].…”

Section: Magnesium Deficiency and High Social Impact Diseasesmentioning

confidence: 99%

Magnesium: Biochemistry, Nutrition, Detection, and Social Impact of Diseases Linked to Its Deficiency

et al. 2021

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Magnesium plays an important role in many physiological functions. Habitually low intakes of magnesium and in general the deficiency of this micronutrient induce changes in biochemical pathways that can increase the risk of illness and, in particular, chronic degenerative diseases. The assessment of magnesium status is consequently of great importance, however, its evaluation is difficult. The measurement of serum magnesium concentration is the most commonly used and readily available method for assessing magnesium status, even if serum levels have no reliable correlation with total body magnesium levels or concentrations in specific tissues. Therefore, this review offers an overview of recent insights into magnesium from multiple perspectives. Starting from a biochemical point of view, it aims at highlighting the risk due to insufficient uptake (frequently due to the low content of magnesium in the modern western diet), at suggesting strategies to reach the recommended dietary reference values, and at focusing on the importance of detecting physiological or pathological levels of magnesium in various body districts, in order to counteract the social impact of diseases linked to magnesium deficiency.

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Direct and indirect associations between dietary magnesium intake and breast cancer risk

Cited by 29 publications

References 62 publications

The Contribution of Dietary Magnesium in Farm Animals and Human Nutrition

The Contribution of Dietary Magnesium in Farm Animals and Human Nutrition

Low serum magnesium concentration is associated with the presence of viable hepatocellular carcinoma tissue in cirrhotic patients

Magnesium: Biochemistry, Nutrition, Detection, and Social Impact of Diseases Linked to Its Deficiency

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