Direct current stimulation induces mGluR5‐dependent neocortical plasticity

Sun, Yan; Lipton, Jonathan O.; Boyle, Lara M.; Madsen, Joseph R.; Goldenberg, Marti; Pascual‐Leone, Álvaro; Şahin, Mustafa; Rotenberg, Alexander

doi:10.1002/ana.24708

Cited by 52 publications

(55 citation statements)

References 51 publications

(199 reference statements)

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“…Thus, it was concluded that direct-current stimulation may be having its long lasting after-effects due to changes in the connections between neurons, like long-term potentiation (LTP) or long-term depression (LTD) are known to induce. More recent slice work appears to be consistent with this notion (Sun et al, 2016). …”

Section: Tdcs Can Last a Long Timementioning

confidence: 56%

“…Cholinergic, serotonergic, and GABAergic systems have all been shown to be related to tDCS effects (Medeiros et al, 2012). Finally, recent slice work indicates that the long lasting after-effects of direct-current stimulation appears to be due to a molecular cascade involving metabotropic glutamate receptors, NMDA receptors, and GABA that induce long-term depression and potentiation (Sun et al, 2016). In sum, essentially every signaling pathway has been implicated in the molecular and cellular activity that gives rise to the effects we observe with tDCS delivered to human participants.…”

Section: Biophysical Basismentioning

confidence: 99%

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Using transcranial direct-current stimulation (tDCS) to understand cognitive processing

Reinhart

Cosman

Fukuda

et al. 2016

Atten Percept Psychophys

127

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Noninvasive brain stimulation methods are becoming increasingly common tools in the kit of the cognitive scientist. In particular, transcranial direct-current stimulation (tDCS) is showing great promise as a tool to causally manipulate the brain and understand how information is processed. The popularity of this method of brain stimulation is based on the fact that it is safe, inexpensive, its effects are long lasting, and you can increase the likelihood that neurons will fire near one electrode and decrease the likelihood that neurons will fire near another. However, this method of manipulating the brain to draw causal inferences is not without complication. Because tDCS methods continue to be refined and are not yet standardized, there are reports in the literature that show some striking inconsistencies. Primary among the complications of the technique is that the tDCS method uses two or more electrodes to pass current and all of these electrodes will have effects on the tissue underneath them. In this tutorial, we will share what we have learned about using tDCS to manipulate how the brain perceives, attends, remembers, and responds to information from our environment. Our goal is to provide a starting point for new users of tDCS and spur discussion of the standardization of methods to enhance replicability.

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Section: Tdcs Can Last a Long Timementioning

confidence: 56%

Section: Biophysical Basismentioning

confidence: 99%

Using transcranial direct-current stimulation (tDCS) to understand cognitive processing

Reinhart

Cosman

Fukuda

et al. 2016

Atten Percept Psychophys

127

View full text Add to dashboard Cite

show abstract

“…mGluR2, mGluR3, and mGluR5 mature by 15 days after birth in rodents (human age: 0–24 months) [115]. Recent evidence indicates that cathodal tDCS-induced LTD is primarily mediated by mGluR5 receptors [116] and, thus, direct current stimulation protocols may not be less, if at all, effective during the first 2 years after birth in humans.…”

Section: Preclinical Insights Into the E:i Ratio In Developmentmentioning

confidence: 99%

Transcranial Magnetic and Direct Current Stimulation in Children

Hameed

Dhamne

Gersner

et al. 2017

Curr Neurol Neurosci Rep

Self Cite

118

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Promising results in adult neurologic and psychiatric disorders are driving active research into transcranial brain stimulation techniques, particularly transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS), in childhood and adolescent syndromes. TMS has realistic utility as an experimental tool tested in a range of pediatric neuropathologies such as perinatal stroke, depression, Tourette syndrome, and autism spectrum disorder (ASD). tDCS has also been tested as a treatment for a number of pediatric neurologic conditions, including ASD, attention-deficit/hyperactivity disorder, epilepsy, and cerebral palsy. Here, we complement recent reviews with an update of published TMS and tDCS results in children, and discuss developmental neuroscience considerations that should inform pediatric transcranial stimulation.

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“…Multiple mGlu 5 PAMs have robust efficacy in rodent models used to predict antipsychotic efficacy and the treatment of cognitive disturbances (Conn et al, 2009b; Liu et al, 2008; Parmentier-Batteur et al, 2014; Rook et al, 2013). Interestingly, mGlu 5 PAMs enhance induction of both long-term potentiation (LTP) and long-term depression (LTD) at excitatory synapses in the hippocampus and other brain regions (Ayala et al, 2009; Rook et al, 2015; Sarihi et al, 2008; Sun et al, 2016) and can restore deficits in animal models in which synaptic plasticity and cognitive function are impaired (Bhardwaj et al, 2015; Lin et al, 2014; Waung and Huber, 2009; Won et al, 2012). …”

Section: Potential Antipsychotic and Cognition-enhancing Effects Of Mmentioning

confidence: 99%

Allosteric Modulation of GPCRs: New Insights and Potential Utility for Treatment of Schizophrenia and Other CNS Disorders

Foster

Conn

2017

Neuron

210

171

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G-protein coupled receptors (GPCRs) play critical roles in regulating brain function. Recent advances have greatly expanded our understanding of these receptors as complex signaling machines that can adopt numerous conformations and modulate multiple downstream signaling pathways. While agonists and antagonists have traditionally been pursued to target GPCRs, allosteric modulators provide several mechanistic advantages including the ability to distinguish between closely related receptor subtypes. Recently, the discovery of allosteric ligands that confer bias and modulate some, but not all, of a given receptor's downstream signaling pathways can provide pharmacological modulation of brain circuitry with remarkable precision. In addition, allosteric modulators with unprecedented specificity have been developed that can differentiate between subpopulations of a given receptor subtype based on the receptor's dimerization state. These advances are not only providing insight into the biological roles of specific receptor populations, but hold great promise for treating numerous CNS disorders.

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Direct current stimulation induces mGluR5‐dependent neocortical plasticity

Cited by 52 publications

References 51 publications

Using transcranial direct-current stimulation (tDCS) to understand cognitive processing

Using transcranial direct-current stimulation (tDCS) to understand cognitive processing

Transcranial Magnetic and Direct Current Stimulation in Children

Allosteric Modulation of GPCRs: New Insights and Potential Utility for Treatment of Schizophrenia and Other CNS Disorders

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