Direct effect of croton oil on intestinal epithelial cells and colonic smooth muscle cells

Abstract

At a high CO concentration (>20 mg x L(-1)), cell growth and proliferation are inhibited in a dosage-dependent manner. Increase in cell proliferation and in malignant conversion of the cellular phenotype is observed in cells cultured chronically with CO. COX-2 mRNA expression decreases significantly, while human mitochondrial cytochrome C oxidase subunit IImRNA expression increases significantly in HIEC treated with CO. CO also has a direct effect on the contractility of Guinea pig colonic smooth muscle cells.

Effects of essential oil from Croton tiglium L. on intestinal transit in mice

“…We have also reported the direct effect of essential oil of Croton tiglium on human intestinal epithelial cell and guinea pig colonic smooth muscle cells in vitro (Wang et al, 2002a). Keeping in view the traditional use of Croton tiglium in gastrointestinal disturbances and our previous findings, the present study investigated the effects of Croton tiglium oil (CO) on intestinal motility in mice and explored the possible mechanisms.…”

“…The Chinese had written records in the second century b.c. for using Ba-Dou to treat gastrointestinal disorders, intestinal inflammation, rheumatism, headache, peptic ulcer and visceral pain (Qiu, 1996;Wang et al, 2002a;Morimura, 2003;Tsai et al, 2004).…”

M3 muscarinic receptor- and Ca2+ influx-mediated muscle contractions induced by croton oil in isolated rabbit jejunum

“…Croton oil was extracted from the fruit of Croton tiglium L. as previously described (Wang et al, 2002). Croton tiglium L. was provided by Tianjin Zhongxin Pharmaceutical Group Co., Ltd. (Tianjin, China) and identified by Professor Wenyuan Gao from School of Pharmaceutical Science and Technology, Tianjin University, China.…”

“…Croton oil, the fatty oil of Crotonis Fructus, has been reported to have a direct effect on guinea pig colonic smooth muscle cell, regulate the GI transit in mice, and affect inflammatory and immunological milieu (Wang et al, 2002;Wang et al, 2008). However, the pharmacological effect of croton oil on GI motility, and particularly the underlying mechanisms are less explored.…”

Effects of neurotrophins on gastrointestinal myoelectric activities of rats

“…Further studies are needed to elucidate the precise mechanism by which neurotrophins influence smooth muscle contractility and/or enteric nerve functions in the human gastrointestinal tract. Gut motility disorder is common in clinical practice [29][30][31][32][33] , and its suitable treatment should be studied [34][35][36][37][38] . In this respect, our data indicate that neurotrophins are the promising agents capable of modifying transit in the entire gastrointestinal tract and may provide novel treatments for patients with disturbed gut motility, such as Hirschspnmg's disease [28,39] .…”