Direct electron imaging in electron microscopy with monolithic active pixel sensors

Deptuch, G.; Besson, A.; Řehák, P.; Szelezniak, Michal; Wall, J.; Winter, M.; Zhu, Yimei

doi:10.1016/j.ultramic.2007.01.003

Cited by 66 publications

(41 citation statements)

References 21 publications

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“…To reduce the impact of the noise while retaining the edge transition profile, we adapted an analytical fitting method (Yin, et al, 1990) and used the sum of two sigmoid curves (Deptuch, et al, 2007) to fit the edge profile:…”

Section: Resolution Of the Ddd Detectormentioning

confidence: 99%

“…At 1/2 Nyquist frequency (50 lp/mm), the DDD showed a MTF of >12%. Comparing to the publicly available MTF data for Gatan scientific CCD cameras and another active pixel sensor based detector, the MIMOSA V chip (Deptuch, et al, 2007), it is quite clear that the DDD outperforms other technologies at the same spatial frequencies. This advantage does not show up in a plot using the usual scale of 1/pixel (see Figure 3b).…”

Section: Resolution Of the Ddd Detectormentioning

confidence: 99%

“…The MV data was taken from the published MTF curve from a front illuminated MV chip at 350 keV (Deptuch, et al, 2007). The Gatan Ultrascan 1000 and 4000 MTF values were obtained from the public datasheets from Gatan's website * .…”

mentioning

confidence: 99%

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Applications of direct detection device in transmission electron microscopy

Liang

Milazzo

Kleinfelder

et al. 2008

Journal of Structural Biology

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A prototype Direct Detection Device (DDD) camera system has shown great promise in improving both the spatial resolution and the signal to noise ratio for electron microscopy at 120-400 keV beam energies (Xuong, et al., 2007. Methods in Cell Biology, 79, 721-739). Without the need for a resolution-limiting scintillation screen as in the charge coupled device (CCD), the DDD camera can outperform CCD based systems in terms of spatial resolution, due to its small pixel size (5 μm). In this paper, the modulation transfer function (MTF) of the DDD prototype is measured and compared with the specifications of commercial scientific CCD camera systems. Combining the fast speed of the DDD with image mosaic techniques, fast wide-area imaging is now possible. In this paper, the first large area mosaic image and the first tomography dataset from the DDD camera are presented, along with an image processing algorithm to correct the specimen drift utilizing the fast readout of the DDD system.

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Section: Resolution Of the Ddd Detectormentioning

confidence: 99%

Section: Resolution Of the Ddd Detectormentioning

confidence: 99%

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Applications of direct detection device in transmission electron microscopy

Liang

Milazzo

Kleinfelder

et al. 2008

Journal of Structural Biology

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“…Commercial bulk CMOS is the most commonly adopted process for monolithic active pixel sensors (MAPS) [1]. MAPS are being successfully applied to particle physics experiments [2,3], imaging in transmission electron microscopy [4,5,6] and photon imaging [7]. However, MAPS in bulk CMOS technology have several limitations.…”

Section: Introductionmentioning

confidence: 99%

Characterisation of a pixel sensor in SOI technology for charged particle tracking

Battaglia¹,

Bisello²,

Contarato³

et al. 2011

Nuclear Instruments and Methods in Physics Research Section A:

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This paper presents the results of the characterisation of a pixel sensor manufactured OKI 0.2 µm SOI technology integrated on a high-resistivity substrate, and featuring several pixel cell layouts for charge collection optimisation. The sensor is tested with short IR laser pulses, X-rays and 200 GeV pions. We report results on charge collection, particle detection efficiency and single point resolution.

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“…In TEM, replacing phosphorcoupled CCDs with direct detection on CMOS sensor is the latest trend in imaging [10,44,11], to decrease the PSF and enhance the detection quantum efficiency and imaging contrast ratio. Multiple scattering in the sensor is a major limitation, since the typical electron energy is in the range 60 -300 keV.…”

Section: Sensor Thicknessmentioning

confidence: 99%